Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines

Mesquita, Mariana Laundry de; Paula, José Elías de; Pessoa, Cláudia; Moraes, Manoel Odoríco de; Costa-Lotufo, Letı́cia V.; Grougnet, Raphaë͏l; Michel, Sylvie; Tillequin, François; Espindola, Laïla Salmen

doi:10.1016/j.jep.2009.03.018

Cited by 140 publications

(117 citation statements)

References 77 publications

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“…In folk medicine, it is used to treat wounds and ulcers of skin and mucous membranes, tumors, diarrhea, arthritis, and infections of the urinary and respiratory systems (Morton, 1978). Some studies have shown that the medicinal properties of S. terebinthifolius are related to the high content of phenolic derivatives such as gallic acid, methyl gallate, tannins, and flavonoids that are responsible for S. terebinthifolius antioxidant and antitumor activities (Queires et al, 2006;Ceruks et al, 2007;de Mesquita et al, 2009;Santana et al, 2012). Moreover, S. terebinthifolius was included in Brazilian Pharmacopeia (Brandão et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…It is estimated that 60% of anticancer drugs are derived directly or indirectly from medicinal plants ( WHO, 2011), which explains the large amount of research that aims to evaluate biological activities that demonstrate the balance and equilibrium of natural defenses through the action of antioxidants in modulating genomic repair (de Mesquita et al, 2009;Malini et al, 2010). Thus, this study aimed to evaluate the effects of the methanolic extract from leaves of S. terebinthifolius (MEST) in the prevention and/or repair of genotoxic and mutagenic lesions as well as describe the mechanisms of action of MEST in Allium cepa and Swiss mice and compare the two biological models.…”

Section: Introductionmentioning

confidence: 99%

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Antigenotoxic and antimutagenic effects of Schinus terebinthifolius Raddi in Allium cepa and Swiss mice: A comparative study

Fedel-Miyasato¹,

Formagio²,

Auharek³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. It is estimated that 60% of anticancer drugs are derived directly or indirectly from medicinal plants. Schinus terebinthifolius Raddi (Anacardiaceae) is traditionally used in Brazilian medicine to treat inflammation, ulcers, and tumors. Because of the need to identify new antimutagenic agents and to determine their mechanism of action, this study evaluated the chemopreventive activity of the methanolic extract from leaves of S. terebinthifolius (MEST) in Allium cepa cells and in Swiss mice analyzing different protocols of MEST in association with DNA-damaging agents. The antigenotoxic and antimutagenic aspects in peripheral blood were evaluated using the comet and micronucleus assays, respectively. The percentage of damage reduction was used to compare the A. cepa and mice results. Our results showed for the first time that MEST can act as a chemopreventive compound that promotes cellular genome integrity by desmutagenic and bioantimutagenic activities in vegetal and animal models. This finding may therefore have therapeutic applications that can indirectly correlate to the prevention and/or treatment of the degenerative diseases such as cancer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antigenotoxic and antimutagenic effects of Schinus terebinthifolius Raddi in Allium cepa and Swiss mice: A comparative study

Fedel-Miyasato¹,

Formagio²,

Auharek³

et al. 2014

Genet. Mol. Res.

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“…In fact, several plants provide health benefits by exhibiting antihemorrhagic (Mazzolin et al, 2010), antioxidant (Souza et al, 2012), and antimutagenic activities (Vilar et al, 2009b). Moreover, several studies have demonstrated that numerous active compounds from Brazilian Cerrado plants show promising biological properties for cancer therapy (de Mesquita et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice

Fd¹,

Silva²,

Sampaio³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Lafoensia pacari (Lythraceae), popularly known in Brazil as "pacari", is a small tree native to the Cerrado that is used in folk medicine to treat cancer and as an anti-inflammatory and cicatrizing agent. We evaluated the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic activities of an ethanol extract of L. pacari stem bark (EESB) using the Ames test and the mouse bone marrow micronucleus test. In the Ames test, EESB did not significantly increase the number of His + revertants in Salmonella typhimurium tester strains TA98 and TA100 at all doses, demonstrating lack of mutagenicity. Only the highest dose of EESB significantly increased the micronucleated polychromatic erythrocyte frequency in the micronucleus test, indicating mild genotoxicity. EESB produced a mutagenic index lower than the negative control in the Ames test. In the micronucleus test, at all doses, EESB caused a significant decrease in the polychromatic/normochromatic erythrocyte ratio (PCE/NCE) at 24 h compared with the negative control. EESB co-administered together with the respective positive control caused a significant decrease in the number of His + revertant colonies in the Ames test and in the frequency of micronucleated polychromatic erythrocytes in the micronucleus test, demonstrating a DNA protector effect. EESB co-administered with mitomycin C significantly increased the PCE/NCE ratio at all doses, showing an anticytotoxic effect. We conclude that EESB has antigenotoxic and anticytotoxic properties.

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“…Ethanolic extract from stem of K. coriacea at a dose of 60 mg/kg body weight and its dichloromethane semi-pure fraction at dose of 6 mg/kg body weight showed similar antidepressant-like effects after 45 days of oral treatment in Male Wistar rats (Martins et al, 2004(Martins et al, , 2006. Hexane and dichloromethane extracts from different parts of this species have anticancer activity against SF-295 (brain); HCT-8 (human colon carcinoma); MDA-MB-435 (melanome) and HL-60 (leukemia) with IC50 values ranging from 3.0 to 34.9 µg/mL (Mesquita et al, 2009). Recently, Sobral et al (2009) demonstrated antibacterial activity against Micrococcus luteus (CIM 7.8 µg/mL), Bacillus subitilis (CIM 15.6 µg/mL), Staphylococcus aureus (CIM 31.2 µg/mL) and Streptococcus mutans (CIM 31.2 µg/mL) of the dichloromethane extract from trunk of Kielmeyera cuspidata.…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis

Cota¹,

Siqueira²,

Oliveira³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Many phenolic compounds such as xanthones, quinones and coumarins have been isolated from Kielmeyera species; however the presence of flavonoids have been showed in other genera in the Calophylleae tribe as Caraipa, Mesua and Calophyllum. Six known glycosidic flavonoids: quercetin 3-β-O-galactopyranoside (1), quercetin 3-β-O-glucopyranoside (2), quercetin 3-O-α-rhamnoside (3), luteolin 6-C-β-glucopyranoside (4), isovitexin (5), kaempferol 3-O-α-rhamnoside (6) and one triterpene, lupenone (7) were isolated, for the first time, from organic crude extract of Kielmeyera variabilis Mart. & Zucc., Calophyllaceae, leaves. The crude organic extract from K. variabilis leaves exhibited 95% of leishmanidal activity at 20 µg/mL on amastigote-like form of Leishmania (Leishmania) amazonensis in vitro model and only compound 3 showed 40-45% of growth inhibition at concentration ranging from 0.78 to 20 µg/mL. In addition, quercetin 3-O-α-rhamnoside (quercitrin) was found to be the major metabolite. Our results and previous reports suggest that synergistic effects of flavonoid glycosides are the cause of significant leishmanidal activity of the crude organic extract from K. variabilis leaves.

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Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines

Cited by 140 publications

References 77 publications

Antigenotoxic and antimutagenic effects of Schinus terebinthifolius Raddi in Allium cepa and Swiss mice: A comparative study

Antigenotoxic and antimutagenic effects of Schinus terebinthifolius Raddi in Allium cepa and Swiss mice: A comparative study

Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice

Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis

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