Cytotoxic Activity of Citral from Cymbopogon nardus as Anticancer of MCM-B2 Cell

Abstract

Cancer is a deadly disease caused by cell abnormalities characterized by uncontrolled cell growth. One type of cancer that is the second leading cause of death is breast cancer. Lemongrass (Cymbopogon nardus) is a plant containing citral and geraniol which has the potential as an anticancer. This research was aimed to analyze the potential of essential oils from citronella as antiproliferation of MCM-B2 breast cancer cells. The results of this research showed that lemongrass essential oil was able to significantly reduce the growth of MCM-B2 cancer cells (p<0.05). The concentration of 3 ppm showed an significant difference in doxorubicin, and the concentration of 24 ppm had the highest inhibitory activity with an IC50 value of 5.38 ppm.
 
 Keywords: Antiproliferation, breast cancer, MCM-B2, essential oils, fragrant lemongrass

Evaluation of the In Vitro Antiparasitic Effect of the Essential Oil of Cymbopogon winterianus and Its Chemical Composition Analysis

“…Essential oil of C. winterianus, as well as that of C. citratus, has already been shown to inhibit cytotoxicity in murine neutrophils through a mechanism not related to free radical scavenging [34]. The low cytotoxicity observed here (Figures 2 and 5, Table 2) is probably due to the absence of compounds known to be toxic to mammalian cells in EOCw (Table 1), such as citral [35]. In the study by Sinha et al [36], a weak cytotoxic effect of citronella essential oil on human lymphocytes was observed, although the use of geraniol had the opposite effect.…”