Cytotoxic Activity of Extracts from the Intact Plant and Cell Cultures of Podophyllum peltatum Against Cervical Cancer Cells

Kitaeva, M.P.; Aksenov, A. A.; Федотчева, Т. А.; Semeikin, A. V.; Shimanovsky, N. L.

doi:10.1007/s11094-022-02652-9

Cited by 3 publications

(1 citation statement)

References 23 publications

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“… Newman and Cragg (2020) reported that from 1981 to 2019 there was 1881 new remedies, which were approved for medical application, and the 22.9% of them are of natural origin. Phytotherapy plays an important role in the treatment of cardiovascular ( Kirichenko et al, 2020 ; Archakova et al, 2022 ; Karahan et al, 2022 ), immune ( Babich et al, 2020 ; Ligacheva et al, 2022 ; Abdugafurova et al, 2024 ), cancer ( Medvedev et al, 2020 ; Kitaeva et al, 2022 ; Jia-Xing et al, 2023 ), and infectious diseases ( Gorlenko et al, 2020 ; Luzhanin et al, 2022 ; Zrig, 2022 ). According to the WHO, herbal medications are the main choice in many regions of the world ( Aware et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects

Terekhov,

Savina,

Pankov

et al. 2024

Front. Chem.

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Dihydroquercetin (DHQ) is a representative of flavonoids that is available on the market as a food supplement and registered as an active pharmaceutical ingredient. The structure of this compound is characterized by the presence of two chiral centers in positions 2 and 3 of the pyranone ring. Current regulatory documentation on DHQ lacks quantitative analysis of the stereoisomers of this flavanonol. This poses potential risks for consumers of DHQ-based dietary supplements and developers of new drugs. This review was conducted to systematize data on the pharmacology of DHQ stereoisomers and the possible methods of controlling them in promising chiral drugs. We found that relying on literature data of polarimetry for the identification of DHQ stereoisomers is currently impossible due to these heterogeneities. NMR spectroscopy allows to distinguishing between trans- and cis-DHQ using chemical shifts values. Only HPLC is currently characterized by sufficient enantioselectivity. Regarding pharmacology, the most active stereoisomer of DHQ should be identified, if the substituents in chiral centers both take part in binding with the biological target. The significant impact of stereochemical structure on the pharmacokinetics of DHQ isomers was reported. The question about these toxicity of these compounds remains open. The results of the conducted review of scientific literature indicate the necessity of revising the pharmacology of DHQ taking into account its stereoisomerism.

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Section: Introductionmentioning

confidence: 99%

Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects

Terekhov,

Savina,

Pankov

et al. 2024

Front. Chem.

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Changes in the Contents of Podophyllotoxin and other Phenolic Compounds in Acetone Extracts of Suspension Cell Cultures of Podophyllum peltatum L. at Different Stages of Cultivation

et al. 2023

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Comparative evaluation of the biological activity of quercetin-like compounds

Tsymbal

2024

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Objective. To determine the degree of manifestation of antioxidant, oncoprotective, anti-inflammatory properties of quercetin-like compounds of a number of flavonoids based on a comparative analysis of the complexing activity of oxygen-containing functional groups. Materials and methods. Analysis and systematization of literary data, a rationalistic method of modeling the properties of molecular systems. Results. The expediency of determining the structural identity of separate sections of molecules of various flavonoids for the subsequent determination of the degree of correlation of their biological properties is shown. Conclusion. Comparison of biological properties of substances of plant origin in combination with application of the latest extraction methods will help to accelerate drug development at the stage of obtaining a new active substance.

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Cytotoxic Activity of Extracts from the Intact Plant and Cell Cultures of Podophyllum peltatum Against Cervical Cancer Cells

Cited by 3 publications

References 23 publications

Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects

Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects

Changes in the Contents of Podophyllotoxin and other Phenolic Compounds in Acetone Extracts of Suspension Cell Cultures of Podophyllum peltatum L. at Different Stages of Cultivation

Comparative evaluation of the biological activity of quercetin-like compounds

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