Cytotoxic activity of flavonoid from local plant Eriocaulon cinereum R.B against MCF-7 breast cancer cells

Abstract

Eriocaulon cinereum R. Br is used as traditional medicine by the local community in Bangka Belitung Island, Indonesia. The plant is processed as an infusion for fever, boosts the immune system, and treats tumor cells. However, scientific research on this species is still limited. The aims of this study were to determine the cytotoxic of E. cinereum against MCF-7 cells. The results suggested that one of the compounds has a good cytotoxic activity. Therefore, it is quite promising in the effort of cancer drug discovery. The active compound has a flavonoid, which plays a role in several anticancer mechanisms. This study provided scientific evidence regarding the utilization of E. cinereum by the local community for cancer therapy. The plant can be further developed as an alternative agent to treat cancer or as cancer adjuvant therapy.

Anticancer Activity of Subfractions from Eriocaulon cinereum R.Br Extract in Cervical Cancer Cells

“…The active isolate that was successfully isolated from the fraction, which is a flavonoid isolate, has an IC50 of 7.28 μg/mL. [20][21][22] The same results were also found upon testing toxicity on T47D cells. The subfraction containing terpenoids had a lower IC50 compared to the dichloromethane fraction, with IC50 values of 84.8 and 131.921 μg/mL, respectively.…”

“…These results follow previous studies of MCF-7 or T47D cells, in line with the hypothesis proposed in this study. [20][21][22][23][24][25][26] The compound selectivity index, which was also determined in this study, showed that the selectivity of compounds in normal Vero cells was 2.157, which is classified as being in a good category with a value >2. This shows that the compound is selective and can differentiate between cancer cells and normal cells.…”

“…23,24 However, these results do not align with previous studies on MCF-7 cells, which showed that the subfraction with the best activity contained flavonoids. [20][21][22] This discovery shows that more than one type of active compound, both subfractions of flavonoids and terpenoids, is contained in E. cinereum and can be developed as an anticancer compound. Flavonoid compounds as anticancer agents are also found in many other species of the same genus, namely E. australe and E. sieboldianum.…”

Cycloartobiloxanthone, a Flavonoid with Antidiabetic, Antibacterial and Anticancer Activities from Artocarpus kemando Miq.

“…Flavonoid compounds found in the plant Eriocaulon cinereum R.B. by phytochemical screening was reported to exhibit anticancer activity in MCF-7 cells with an IC50 of 7.28 ± 6.75 μg/mL [49]. According to Slika et al [50], flavonoid compounds have anticancer properties because they are able to eliminate reactive oxygen species (ROS), inhibit oxidase enzyme, chelate metals, and activate antioxidant enzymes.…”