Abstract:Lead molecules containing 1,4‐quinone moiety are intriguing novel compounds that can be utilized to treat cancer owing to their antiproliferative activities. Nine previously reported quinolinequinones (AQQ1‐9) were studied to better understand their inhibitory profile to produce potent and possibly safe lead molecules. The National Cancer Institute (NCI) of Bethesda chose all quinolinequinones (AQQ1‐9) based on the NCI Developmental Therapeutics Program and tested them against a panel of 60 cancer cell lines. … Show more
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