Cytotoxic Activity of Some Spirooxindole-4H-pyran Derivatives

Abstract

Aims: Isatin is a honored scaffold and one of the most favorable class of heterocyclic systems that possesses many interesting biological activities and well-tolerated in humans. Here a series of fifteen spirooxindole-4H-pyran derivatives containing both isatin and pyran moieties (ICa-ICo) will be examine for their anti-cancer activity.
 Study Design: Cytotoxic evaluation of some spirooxindole-4H-pyran derivatives in two cancerous cell lines. 
 Place and Duration of Study: Pharmaceutical Science Research Center and Shiraz Institute for Cancer Research, Medical School in Shiraz University of Medical Sciences, Shiraz, Iran, between June 2018 and July 2019.
 Methodology: MTT assay was used to evaluate the cytotoxic activities of these compounds. The anticancer properties of the tested compounds were determined using A549 and MCF-7 cell lines.
 Results: Among the tested compounds ICc, ICd and ICf showed the best cytotoxic activities against both cancerous cell lines. Compounds ICh and ICj showed desirable cytotoxic activities against A549 cell line. Compound ICb showed desirable cytotoxic activities against MCF-7 cell line.
 Conclusion: We conclude that the isatin-linked pyran analog can serve as a prototype molecule for further development of a new class of anticancer agents.

Microfluidics: Innovations in Materials and Their Fabrication and Functionalization

“…Faghih and Sharp 59 found that a solution of 20% dichloromethane and 80% isopropyl alcohol (IPA), combined with a corona surface treatment, yielded good bond strength and optical transparency for affixing PMMA sheets together. While this technique is limited by the potential for microchannel collapse, another group found that filling PMMA microchannels with a hydrophobic amine-PDMS linker prior to ethanol submersion-assisted bonding prevented channel deformation, as seen in Figure 2B.…”