Cytotoxic alkaloids from the twigs and leaves of <i>Cephalotaxus sinensis</i>

Zhang, Fuxin; Yang, Tao; Yang, Kailing; Zhou, Ruixi; Chen, Wenwen; Liu, Zhetong; Zhan, Guanqun; Guo, Zengjun

doi:10.1039/d2ob01980a

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…Alscholarines A 21 and B 22, from Alstonia scholaris, are rearranged vallesamine-type alkaloids with unprecedented skeletons. 16 Penerpene S 23 is produced together with several indole-diterpenoids by the marine coral-derived fungus Aspergillus sp. ZF-104.…”

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confidence: 99%

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Hill,

Sutherland

2023

Nat. Prod. Rep.

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confidence: 99%

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Hill,

Sutherland

2023

Nat. Prod. Rep.

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“…The SARS‐CoV‐2 3CL pro inhibitory activity of the isolated compounds was evaluated using an enhanced SARS‐CoV‐2 3CL pro inhibiter screening kit (P0315S, Beyotime Biotechnology) as previously described [30] …”

Section: Methodsmentioning

confidence: 99%

Molecular Networking Accelerated Discovery of Biflavonoid Alkaloids from Cephalotaxus sinensis

Guo

Zhang

Zhou

et al. 2023

Chemistry & Biodiversity

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Four undescribed biflavonoid alkaloids, sinenbiflavones A–D, were isolated from Cephalotaxus sinensis using a MS/MS‐based molecular networking guided strategy. Their structures were elucidated by series of spectroscopic methods (HR‐ESI‐MS, UV, IR, 1D, and 2D NMR). Sinenbiflavones A–D are the first examples of amentoflavone‐type (C‐3’–C‐8’’) biflavonoid alkaloids. Meanwhile, sinenbiflavones B and D are the unique C‐6‐methylated amentoflavone‐type biflavonoid alkaloids. Sinenbiflavone D showed weak SARS‐CoV‐2 3CLpro inhibitory activity with 43 % inhibition rate at 40 μM.

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“…18,19 pharmacologists because of their strong anticancer action. 20,21 Cephalotaxus sinensis is used as a traditional medicine for the treatment of cough, dyspepsia, ascariasis, and inflammation. 22 We know very little about the typical Cephalotaxus alkaloids found in C. sinensis, which serves as a reminder that there may be additional novel alkaloids with important biological activities.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The distribution of Cephalotaxus has been restricted to the northeastern states of India, which has made it difficult to study and use its therapeutical properties. Over the past years, researchers isolated various interesting secondary metabolites from the Cephalotaxus genus which included alkaloids, flavonoids, terpenoids, and phenylpropanoids. , Evidently, alkaloids, particularly those of the cephalotaxine group, have drawn significant interest from pharmaceutical scientists and pharmacologists because of their strong anticancer action. , Cephalotaxus sinensis is used as a traditional medicine for the treatment of cough, dyspepsia, ascariasis, and inflammation . We know very little about the typical Cephalotaxus alkaloids found in C.…”

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confidence: 99%

Screening for the Biochemical Profile and Biological Activity in Cephalotaxus and Taxus Collected from North-Eastern Himalayas

Dixit

Singh

Singh³

et al. 2023

ACS Agric. Sci. Technol.

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Cephalotaxus and Taxus both possess significant medicinal values in the traditional medicine system. Even though the tribal communities in the Himalayas have used these genera extensively, little is known about their ethnopharmacological properties. The study aims to investigate the biochemical profile and biological activities of various extracts of Cephalotaxus and Taxus. This study examined six different accessions of Cephalotaxus and Taxus growing in the northeastern Himalayan region of India for their biochemical components and biological activities. This report considers three species of Cephalotaxus, namely, C. mannii, C. sinensis, and C. griffithii, and one species of Taxus viz. Taxus wallichiana. The stem and leaf extracts of all six selected accessions were biochemically characterized using HPLC/LC–MS. Results have demonstrated the presence of several medicinally important chemicals like harringtonine, rutin, caffeic acid, gallic acid, and a few other biologically active compounds. The isolates were tested for their antibacterial and anti-plasmodial properties. The zone of inhibitions for various extracts ranged from 3–11 mm in the case of Cephalotaxus and 3–6 mm for Taxus. Leaf and stem extracts of all six accessions were found negative for antiplasmodial properties. The data from this study can further serve as a framework for a thorough analysis of various compounds and their antibacterial and antimalarial properties.

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Cytotoxic alkaloids from the twigs and leaves of Cephalotaxus sinensis

Abstract: Twelve new Cephalotaxus alkaloids (1–12) and nine known analogues (13–21) were isolated and identified from the twigs and leaves of Cephalotaxus sinensis. The structures of new compounds (1–12) were elucidated...

Cited by 5 publications

References 36 publications

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Molecular Networking Accelerated Discovery of Biflavonoid Alkaloids from Cephalotaxus sinensis

Screening for the Biochemical Profile and Biological Activity in Cephalotaxus and Taxus Collected from North-Eastern Himalayas

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