Cytotoxic and Antimigratory Activities of Phenolic Compounds from<i>Dendrobium brymerianum</i>

Klongkumnuankarn, Pornprom; Busaranon, Kesarin; Chanvorachote, Pithi; Sritularak, Boonchoo; Jongbunprasert, Vichien; Likhitwitayawuid, Kittisak

doi:10.1155/2015/350410

Cited by 67 publications

(70 citation statements)

References 23 publications

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“…Boonchoo Sritularak in a previous study [7][8][9] . 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,4,6-tripyridyl-s-triazine (TPTZ), and 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox) were purchased from Sigma-Aldrich Chemical Co. (St. Louis, MO, USA).…”

Section: Chemicals and Reagentsmentioning

confidence: 99%

“…Pharmacological studies have demonstrated that moscatilin has antimutagenic activity in human colorectal cancer cells and anti-angiogenesis activity was seen in vitro and in vivo tests 5,6 . Bibenzyl and phenanthrene compounds, such as gigantol, moscatilin and lusianthridin, exhibit anti-migratory activities and can inhibit filopodia formation in nonsmall cell lung cancer cells [7][8][9] . In addition, the antiplatelet aggregating activity of moscatilin, homoeriodictyol and gigantol was reported in an in vitro test 10 .…”

Section: Introductionmentioning

confidence: 99%

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The contents of bibenzyl derivatives, flavonoids and a phenanthrene in selected Dendrobium spp. and the correlation with their antioxidant activity

Choonong¹,

Sermpradit²,

Kitisripanya³

et al. 2019

ScienceAsia

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Dendrobium spp. (the Orchidaceae family) is widely distributed in Asian countries. The fresh or dried stems of Dendrobium spp. have long been used in traditional Chinese medicine for their tonic and antipyretic properties. Bibenzyl derivatives (moscatilin, gigantol, crepidatin, and chrysotoxin), flavonoids (eriodictyol and homoeriodictyol) and phenanthrene lusianthridin are the major active compounds in the stems of Dendrobium spp. Most of these compounds have been recorded in these plants in Thailand; however, their concentrations have not yet been reported. Therefore, in this study, dried stems of selected Dendrobium spp. (33 species) in Thailand were extracted and analyzed by using high-performance liquid chromatography (HPLC). The HPLC method was performed on a reversed-phase column using a mobile phase gradient system of 20-32% acetonitrile in 1.5% acetic acid with a flow rate of 0.8 ml/min and a detection wavelength of 280 nm. The HPLC method displayed good linearity with coefficients of determination (R 2 > 0.997) for the seven active compounds analyzed. The variation in intra-and inter-day analysis (%RSD) was less than 0.5%. Additionally, the extracts of selected Dendrobium spp. were investigated for antioxidant activity by DPPH and FRAP radical scavenging assays. The results showed good activities in some species. The correlation between the seven active compounds and the antioxidant levels (IC 50 and FRAP values) were significant in bibenzyl derivatives and homoeriodictyol as determined by the Pearson correlation. In conclusion, the developed HPLC method can be used for the determination of active compounds in Dendrobium spp., which is useful for further studies of the species containing the highest levels of these compounds.

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Section: Chemicals and Reagentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The contents of bibenzyl derivatives, flavonoids and a phenanthrene in selected Dendrobium spp. and the correlation with their antioxidant activity

Choonong¹,

Sermpradit²,

Kitisripanya³

et al. 2019

ScienceAsia

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“…[80] Other authors found that several phenolic constituents isolated from D. nobile, together with moscatilin (40), gigantol (44), lusianthridin (a dihydrophenanthrene), and dendroflorin showed cytotoxicity against human lung cancer cell lines with IC 50 values of 196.7, 23.4, 65.0, and 125.8 lg/ml, respectively, and exhibited anti-migratory property at nontoxic concentrations. [81] More recently, 44 showed promising activity against cancer cells due to suppression of epithelial to mesenchymal transition (EMT) in non-small cell lung cancer cells (H460). Western blot analysis has revealed that gigantol (44) attenuates the activity of ATP-dependent tyrosine kinase (AKT), thereby inhibiting the expression of the major EMT transcription factor (Slug), by both decreasing its transcription and increasing its degradation.…”

Section: Dihydrostilbenoids and Related Derivativesmentioning

confidence: 99%

“…Other authors found that several phenolic constituents isolated from D . nobile , together with moscatilin ( 40 ), gigantol ( 44 ), lusianthridin (a dihydrophenanthrene), and dendroflorin showed cytotoxicity against human lung cancer cell lines with IC 50 values of 196.7, 23.4, 65.0, and 125.8 μg/ml, respectively, and exhibited anti‐migratory property at nontoxic concentrations . More recently, 44 showed promising activity against cancer cells due to suppression of epithelial to mesenchymal transition (EMT) in non‐small cell lung cancer cells (H460).…”

Section: Introductionmentioning

confidence: 99%

Bioactive Secondary Metabolites from Orchids (Orchidaceae)

Sut

Maggi

Dall’Acqua

2017

Chemistry & Biodiversity

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The Orchidaceae family is the largest group of flowering plants in the Angiosperm monocotyledons spread on our planet. Its members, called orchids, are herbs or epiphytes with showy flowers distributed mainly in tropical regions. Several classes of phytoconstituents have been so far isolated from therapeutically-used orchids showing a great chemical diversity. Among them, phenolic derivatives have been studied for their biological activities, especially in the field of cancer, inflammation, and neurodegeneration. On the other hand, limited information has been so far obtained on the numerous alkaloids and terpenoids isolated from several orchid species. Recent articles revealed pronounced effects of some alkaloids on the CNS. Published literature on orchids that are used in traditional medicine has been reviewed in this work indicating a great potential of such organisms as source of chemical entities for the development of new drugs.

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“…Many studies have revealed that natural products isolated from Dendrobium species possess anticancer properties including anti-proliferation, anti-migration, anti-metastasis, and apoptotic induction in lung cancer (108)(109)(110). Gigantol, a bibenzyl phenolic compound derived from several medicinal orchids, has been shown to inhibit proliferation, migration, EMT and CSC phenotype in lung cancer cells (111)(112)(113)(114). At non-toxic doses (below 20 μM), gigantol isolated from Dendrobium draconis could suppress tumor spheroid formation and decrease lung CSC marker proteins, including CD133 and ALDH1A1, in non-small-cell lung cancer NCI-H460 cells (112).…”

Section: Natural Product Targeting Lung Cancer Stem Cellsmentioning

confidence: 99%

Lung Cancer Stem Cells and Cancer Stem Cell-targeting Natural Compounds

2018

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The novel information regarding molecular and translational research have created a paradigm shift in the understanding of lung cancer biology, revealing the more precise target for anti-cancer drug discovery. Lung cancer is a leading cause of cancer death worldwide accounting for approximately 1 in 5 of all cancer-related deaths. The most important causes of death in such a cancer involves the treatment failure as well as the spreading of cancer cells to distant sites which the cancer stem cell (CSC) within the tumor is accepted as a key driver. CSC is a rare special population of cancer cells exhibiting high tumorigenic properties together with self-renewal and differentiation capability. CSC is not only linked with high tumor-initiating activity, but is also implicated in chemotherapeutic resistance, metastasis, epithelial to mesenchymal transition, and recurrence. Thereafter, novel therapeutic strategies targeting these CSCs are considered in order to improve long-term clinical outcome. Here, we provide sufficient data regarding the biology of CSC in lung cancer, known CSC markers and cellular signals, and promising compounds targeting the stem cell signals in lung cancer that may benefit the development of novel anti-cancer treatment.

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Cytotoxic and Antimigratory Activities of Phenolic Compounds fromDendrobium brymerianum

Cited by 67 publications

References 23 publications

The contents of bibenzyl derivatives, flavonoids and a phenanthrene in selected Dendrobium spp. and the correlation with their antioxidant activity

The contents of bibenzyl derivatives, flavonoids and a phenanthrene in selected Dendrobium spp. and the correlation with their antioxidant activity

Bioactive Secondary Metabolites from Orchids (Orchidaceae)

Lung Cancer Stem Cells and Cancer Stem Cell-targeting Natural Compounds

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