Cytotoxic and antioxidant properties of phenolic compounds fromTagetes patulaflower

Abstract

Compound 2 from T. patula flower exhibited both growth inhibitory and cytotoxic properties while 1 and 3 were only growth inhibitory against HeLa. 1-3 also displayed antioxidant properties implying its probable role in growth inhibition/cytotoxic action. The present study provides scientific evidence for the use of T. patula flower in cancer treatment by traditional healer.

Qualitative HPLC‐DAD/ESI‐TOF‐MS Analysis, Cytotoxic, and Apoptotic Effects of Croatian Endemic Centaurea ragusina L. Aqueous Extracts

“…Some studies showed that luteolin and kaempferol derivatives exhibit cytotoxic activity. [ ][ ] Patulitrin showed growth inhibitory effect against HeLa cells …”

“…[61] [62] Patulitrin showed growth inhibitory effect against HeLa cells. [64] Conclusions Centaurea ragusina flower and herba AE showed good cytotoxic activity against human bladder (T24) and human glioblastomma (A1235) cancer cell lines. Apparent cytotoxic activity of tested C. ragusina AE can be connected with chemical composition of both tested extracts.…”

Isolation of Ceramides from Tagetes patula L. Yellow Flowers and Nematicidal Activity of the Fractions and Pure Compounds against Cyst Nematode, Heterodera zeae

“…The assignment of 1 H-NMR and 13 C-NMR chemical shifts of the core portion of compounds 1-5 was carried out by 2D NMR experiments ( Table 2). The spectra exhibited the characteristic signals of amide, O-bearing methylene and methine groups, nitrogenous methine, and two unbranched long chain methylene envelops with one double bond character ( Table 2, Figure 1).…”

“…Another insoluble fraction, JYM-PV155AIN was evaluated through EI-MS, HR-EI-MS, 1 H-NMR and 13 C-NMR spectra which disclosed its structure as β-sitosterol glucoside (6; Figure 1) whereas, JYM-PV157AIN was found to be a mixture of 6 and ceramides (1 -5). β-Sitosterol glucoside (6) was identified by 1 H-and 13 C-NMR spectroscopy ((D 5 )pyridine) and comparison with previously published data.…”

“…[30] 1 H-NMR (400 MHz, C 5 D 5 N): 0.65 (s, HÀ C(18), 3H); 0.85 -0.91 (m, HÀ C (26,27,29), 9H); 0.92 (s, HÀ C(19), 3H); 0.98 (d, J = 6.4 HÀ C(21), 3H); 1.02 -2.71 (m, CH 2 ); 3.91 -3.98 (m, HÀ C(5'), HÀ C(3)); 4.06 (t, J = 8, HÀ C(2')); 4.25 -4.32 (m, HÀ C(3'), HÀ C(4')); 4.41 (dd, J = 11.60, 5.2, H b À C(6')); 4.56 (dd, J = 11.70, 2.60, H a À C(6')); 5.06 (d, J = 7.60, HÀ C(1')), 5.31 -5.35 (m, HÀ C(6)). 13 C-NMR (100 MHz, C 5 D 5 N): 37.50 (C(1)); 30.28 (C(2)); 78.48 (C(3); 39.36 (C(4)); 140.94 (C(5)); 121.92 (C(6)); 32.18 (C(7)); 32.08 (C(8)); 50.37 (C(9)); 36.95 (C(10)); 21.29 (C(11)); 39.97(C(12)); 42.50 (C(13)); 56.85 (C(14)); 24.52 (C(15)); 28.55 (C(16)); 56.27 (C(17)); 11.98 (C(18)); 19.43 (C(19)); 36.39 (C(20)); 19.02 (C(21)); 34.24 (C(22)); 26.44 (C(23)); 46.07 (C(24)); 29.50 (C(25)); 19.23 (C(26)); 19.98 (C(27)); 23.42 (C(28)); 12.16 (C(29)); 102.60 (C(1')); 75.36 (C(2')), 78.62 (C(3')); 71.74 (C(4')); 78.15 (C(5')); 62.87 (C-6'). EI-MS: 414 (2.07, M + À 162), 397 (28.40), 383 (5.14), 255 (8.50…”