Cytotoxic and antiplasmodial substances from marine-derived fungi, Nodulisporium sp. and CRI247-01

Kasettrathat, Chairut; Ngamrojanavanich, Nattaya; Wiyakrutta, Suthep; Mahidol, Chulabhorn; Ruchirawat, Somsak; Kittakoop, Prasat

doi:10.1016/j.phytochem.2008.08.005

Cited by 62 publications

(53 citation statements)

References 23 publications

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“…Representatives of this group are far related from the Xylariales, which might indicate that the biosynthetic pathway of vermelhotin (4) has evolved independently multiple times during the evolution of fungi. The cytotoxicity of 4 was already reported by Kasettrathat et al (2008), who in addition found activity against various cancer cell lines. The structurally very similar hypoxyvermelhotin A (1) showed a slightly weaker cytotoxic activity.…”

Section: Discussionsupporting

confidence: 61%

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Hypoxyvermelhotins A–C, new pigments from Hypoxylon lechatii sp. nov

Kuhnert

Heitkämper

Fournier³

et al. 2014

Fungal Biology

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JournalFungal biology ABSTRACTA new species of Hypoxylon was discovered, based on material collected in the Caribbean and French Guiana and recognised on the basis of new combination of morpholological characters in comparison with type and authentic material of macroscopically similar taxa. These findings were corroborated by the rather isolated positions of its ITS-nrDNA and beta-tubulin DNA sequences in molecular phylogenies. However, the most salient feature of this fungus only became evident by a comparison of its stromatal HPLC profile, revealing several secondary metabolites that were hitherto not observed in stromata of any other member of the Xylariaceae. Part of the stromata were subsequently extracted to isolate these apparently specific components, using preparative chromatography. Five metabolites were obtained in pure state, and their chemical structures were elucidated by means of high resolution mass spectrometry and nuclear magnetic resonance spectroscopy. They turned out to be tetramic acid derivatives of the so-called vermelhotin type. Aside from vermelhotin, previously isolated from cultures of endophytic fungi, we identified three novel congeners, for which the trivial names hypoxyvermelhotins A-C were proposed. Like vermelhotin, they constitute red pigments and a preliminary biological characterisation revealed them to have rather strong cytotoxic and moderate to weak antimicrobial effects. These results further illustrate the high diversity of unique secondary metabolites in stromata of the hypoxyloid Xylariaceae, a family in which biological diversity seems to parallel the chemical diversity of their bioactive principles to a great extent.2

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Section: Discussionsupporting

confidence: 61%

“…The new metabolites hypoxyvermelhotins A -C (1 -3) represent derivatives of the tetramic acid antibiotic vermelhotin (4), which has been reported from three fungal endophytes (Hosoe et al 2006, Kasettrathat et al 2008, Leyte-Lugo et al 2012. Two of those belong to the order Pleosporales.…”

Section: Discussionmentioning

confidence: 99%

Hypoxyvermelhotins A–C, new pigments from Hypoxylon lechatii sp. nov

Kuhnert

Heitkämper

Fournier³

et al. 2014

Fungal Biology

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“…Although there are no reports of multicolanic acid and related derivatives being synthesised by other filamentous fungi, (Bentley et al, 1962), Nodulisporacid A by Nodulisporium sp. (Kasettrathat et al, 2008), vulpinic acid and pinastric acid by Tuckermannopsis pinastri (Golojuch and Lawrey, 1988), penicillic acid by Penicillium cyclopium and viridicatic acid by Penicillium viridicatum (Gedge and Pattenden, 1979). Labelling studies suggested that multicolosic acid is a polyketide synthesised by oxidative cleavage of an aromatic precursor 6-pentylresorcylate (Holker et al, 1983(Holker et al, , 1987.…”

Section: Production Of -Butyrolactonementioning

confidence: 99%

Quorum sensing as a method for improving sclerotiorin production in Penicillium sclerotiorum

Raina

Odell

Keshavarz

2010

Journal of Biotechnology

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“…Our continuing search for bioactive compounds from marine-derived fungi isolated from Thai marine invertebrates has led to the discovery of many bioactive compounds (Ingavat et al, 2009;Kasettrathat et al, 2008;Prachyawarakorn et al, 2008). In our experience, these fungi could grow rapidly in salt containing media (seawater), but most of them hardly grow in media without salt supplements, and sometimes, those that do grow in non-saline media change their morphology when cultured under such conditions.…”

Section: Introductionmentioning

confidence: 99%