Cytotoxic and apoptotic effect of citrus flavonoid naringin in treating pa-1 ovarian cancer cells

Jarrett, Nebita Maria; Christobel, R Gloria Jemmi; Abirami, M.; Sundar, J Shyam; Radhakrishnan, Sridhar; Deepa, Sathyaseelan S.; Abirami, S.; Samuel, Shila

doi:10.5958/0974-360x.2020.00716.7

Cited by 3 publications

(1 citation statement)

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“…Park and colleagues (39) showed that naringin signi cantly induced antiproliferative activity in THP-1 human leukemia cells, which is mediated by apoptosis induction. Another study reported the toxic effects of naringin on pa-1 ovarian cancer cells (40). Also, the cytotoxic effects of naringin on breast cells (MCF-7) have also been shown (36,41).…”

Section: Discussionmentioning

confidence: 94%

The Combined Therapeutic Effect of Capecitabine and Naringin on HER2+ (SK-BR-3) and HER2- (MCF-7) Human Breast Cancer Cells Lines

Soltannezhad,

Jouni,

Osgoei

2023

Preprint

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Breast cancer is one of the most common cancers among women. The use of natural products to improve the effectiveness of chemotherapy drugs against the proliferation of cancer cells is increasing. Here, we hypothesized that naringin in combination with capecitabine may have a synergistic effect on inhibiting proliferation and inducing apoptosis in MCF-7 and SK-BR-3 breast cancer cell lines. MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) was performed to study the effect of drugs alone and in combination on the cytotoxicity of cell lines and to determine IC50 and Combination Index (CI). Moreover, the expression of Bax and Bcl-2 and caspase3 apoptotic markers were measured by Real-Time PCR after treatment. The MTT results showed that the IC50 of naringin and capecitabine in the MCF-7 cell line was 58 µg ml− 1 and 619.36 µg ml− 1, respectively, and the IC50 of these compounds for the SK-BR-3 cell line was 56.65 µg ml− 1 and 679.51 µg ml− 1. The combined use of naringin and capecitabine led to a significant decrease in the IC50 of these compounds, and the CI values were less than 1, which indicates the synergistic effects of these compounds. The gene expression results also showed an increase in the ratio of Bax/Bcl-2 by naringin-capecitabine compared with capecitabine in both cell lines. Naringin-capecitabine-induced cell death was probably controlled by caspase-3 and Bax/Bcl-2-dependent apoptosis. Also, the combination of naringin-capecitabine has more antiproliferative properties on HER2+ cells compared with HER2−.

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Section: Discussionmentioning

confidence: 94%

The Combined Therapeutic Effect of Capecitabine and Naringin on HER2+ (SK-BR-3) and HER2- (MCF-7) Human Breast Cancer Cells Lines

Soltannezhad,

Jouni,

Osgoei

2023

Preprint

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Therapeutic role of naringin in cancer: molecular pathways, synergy with other agents, and nanocarrier innovations

Alhalmi,

Amin,

Ralli

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Phytochemical Analysis and In Vitro Anticancer Activity of Enteromorpha compressa against Ovarian Cancer

Jothi

Jayaprakash

2022

RJPT

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Enteromorpha compressa seaweeds were evaluated for its in vitro anticancer activity on ovarian cancer cell line. Enteromorpha compressa was collected in and around Mandapam Coast, Rameshwaram, Ramanathapuram District, Tamil Nadu and extracted with 100mL of ethanol using Soxhlet apparatus. The extract showed the presence of phytochemical constituents like alkaloids, saponins, tannins, glycosides, flavonoids, phenols, steroids, terpenoids, quinones and proteins. Total flavonoid content in the chloroform bark extract, using the calibration curve was found to be 1.73mg of quercetin equivalents/g dry weight of the extract. Seaweed extract was subjected to Thin Layer Chromatography for flavonoid detection. The IC50 value of E. compressa extract was found to be 37.68µg/mL against PA1 ovarian cell line compared to the anticancer drug Cisplatin. Hence, the extract may be further analyzed for its potential pharmacological activity against ovarian cancer.

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Cytotoxic and apoptotic effect of citrus flavonoid naringin in treating pa-1 ovarian cancer cells

Cited by 3 publications

References 0 publications

The Combined Therapeutic Effect of Capecitabine and Naringin on HER2+ (SK-BR-3) and HER2- (MCF-7) Human Breast Cancer Cells Lines

The Combined Therapeutic Effect of Capecitabine and Naringin on HER2+ (SK-BR-3) and HER2- (MCF-7) Human Breast Cancer Cells Lines

Therapeutic role of naringin in cancer: molecular pathways, synergy with other agents, and nanocarrier innovations

Phytochemical Analysis and In Vitro Anticancer Activity of Enteromorpha compressa against Ovarian Cancer

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