Cytotoxic and larvicidal activities of <i>Stemona</i> alkaloids from the aerial parts and roots of <i>Stemona curtisii</i> Hook.f.

Chalom, Sirinrat; Panyakaew, Jukreera; Phaya, Manlika; Pyne, Stephen G.; Mungkornasawakul, Pitchaya

doi:10.1080/14786419.2019.1709188

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…To date, more than 300 chemical components have been isolated from stemona, including the alkaloid monomers stemofoline and stemospironine with proven insecticidal effects (Chalom et al 2021 ). Both stemofoline and stemospironine are toxic to silkworm larvae, but employ different mechanisms (Sakata et al 1978 ).…”

Section: Discussionmentioning

confidence: 99%

Acaricidal and repellent activities of ethanol extracts of nine chinese medicinal herbs against Rhipicephalus microplus (Acari: Ixodidae)

Jian

et al. 2023

Exp Appl Acarol

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Rhipicephalus microplus is a major threat to the cattle industry worldwide. The intensive use of acaricides and repellents has resulted in drug resistance. Hence, effective and eco-friendly pest control alternatives are urgently needed, especially from natural plant resources. In this study, the acaricidal and repellent activities of nine herbs against the larvae and eggs of R. microplus were evaluated. The results showed that ethanol extracts of star anise (Illicium verum), chaulmoogra (Hydnocarpus anthelmintica), motherwart (Leonurus artemisia), mandarin orange peel (citri reticulatae pericarpium, i.e., peel of Citrus reticulata fruit), and stemona (Stemona sessilifolia) had good contact acaricidal activities of 100, 98, 94, 88 and 86%, respectively, whereas star anise and clove (Syzygium aromaticum) had good fumigant acaricidal activities of 98 and 96%, respectively. The hatching inhibition rate of star anise against R. microplus eggs was 100%. All nine herbs had good real-time repellent rates, but only castor bean and star anise had repellent effects after 48 h (81.3 and 79.6%, respectively). This is the first report of the acaricidal and repellent activities of these medicinal herbs against R. microplus. Ethanol extracts of these herbs might be considered as potential alternatives to chemical acaricides for control of R. microplus.

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Section: Discussionmentioning

confidence: 99%

Acaricidal and repellent activities of ethanol extracts of nine chinese medicinal herbs against Rhipicephalus microplus (Acari: Ixodidae)

Jian

et al. 2023

Exp Appl Acarol

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“…Thus indicating hydroxylation is specifically directed at C-6 by substrate orientation in the enzyme active site. Interestingly, in plants the pyrido[1,2a]azepine alkaloid stemocurtisine (4) gives rise to other natural products most likely via hydroxylation and ring opening reactions of the azepine ring at C-6 [21,22]. However, it was found to be inert to biotransformation by C. elegans.…”

Section: Discussionmentioning

confidence: 99%

Oxidative biotransformation of stemofoline alkaloids

Phaya

Chalom

Ingkaninan

et al. 2021

Artificial Cells, Nanomedicine, and Biotechnology

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Biotransformations of stemofoline (1a), (2 0 S)-hydroxystemofoline (2a), (11Z)-1 0 ,2 0-didehydrostemofoline (3a) and stemocurtisine (4) were studied through fermentation with Cunninghamella elegans TISTR 3370. Three new stemofoline derivatives; 6 R-hydroxystemofoline (1b), (2 0 S, 6 R)-dihydroxystemofoline (2b) and (11Z,6R)-1 0 ,2 0-didehydro-6-hydroxystemofoline (3b), together with the known compound 1 0 ,2 0didehydrostemofoline-N-oxide (3c), were produced by C-hydroxylation and N-oxidation reactions. Stemocurtisine was not biotransformed under these conditions. The transformed product 1b was four times more potent (IC 50 ¼ 11.01 ± 1.49 mM) than its precursor 1a (IC 50 ¼ 45.1 ± 5.46 mM) as an inhibitor against acetylcholinesterase.

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“…Among them, oxyprotostemonine was the most active component. Chalom et al 112 examined larvicidal activities against the dengue vector, Aedes aegypti of the extract of aerial parts of Stemona curtisii and the pure isolated compounds including 6-hydroxy-5,6-secostemocurtisinoside, stemocurtisine, (11Z)-1 ′ ,2 ′ didehydrostemofoline, and 6-hydroxy-5,6-seco-stemocurtisine. (11Z )-1 ′ ,2 ′ didehydrostemofoline displayed the strongest larvicidal activity with a LC50 value of 2.44 mM.…”

Section: Other Bioactivitiesmentioning

confidence: 99%

“…Chalom et al 112 separated a new Stemona alkaloid glycoside derivative, 6-hydroxy-5,6-secostemocurtisinoside ( 264 ) from the ethanolic extract of the aerial parts of Stemona curtisii (Figure 10). Tuberostemoline F ( 265 ) was produced from the roots of Stemona tuberosa and its structure was elucidated by spectroscopic data, X-ray single-crystal diffraction, and modified Mosher method (Figure 10).…”

Section: Phytochemistrymentioning

confidence: 99%

Isolation and Bioactivities of Stemona Alkaloid: A Review

Nguyen-Thi,

Vo-Cong,

Giang

et al. 2024

Natural Product Communications

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Objective/Background: In Chinese, Vietnamese, and Thai traditional medicine of Southeast Asian countries, Stemonaceae plants have long been employed. Various studies have proved that these herbal plants contain Stemona alkaloids with valuable medicinal value. Although some review articles on Stemona alkaloids have appeared in the literature, they are quite outdated. The current study offers a comprehensive review of the isolation and bioactivities of Stemona alkaloids. The article might be useful for chemists who work in alkaloid chemistry as well as pharmaceutical areas. Methods: “ Stemona alkaloids” was the most useful keyword to search for literature data. References have been collected from various resources such as Google Scholar, SciFinder, and PubMed. More than 120 electronic publications were obtained from these resources. Results: More than 250 Stemona alkaloids from 8 groups have been isolated and structurally elucidated from Stemonaceae plants. Extracts from these plants as well as isolated compounds possess a wide range of bioactivities, such as antituberculosis, antibacterial, antifungal, and antihelmintic properties activities. Conclusion: In this review article, we have summarized 116 studies on the isolation and bioactivities of Stemona alkaloids in the literature. More than 250 Stemona alkaloid compounds have been isolated and identified. In addition, the article also gives an overview of the bioactivities of Stemona alkaloids.

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Cytotoxic and larvicidal activities of Stemona alkaloids from the aerial parts and roots of Stemona curtisii Hook.f.

Cited by 7 publications

References 21 publications

Acaricidal and repellent activities of ethanol extracts of nine chinese medicinal herbs against Rhipicephalus microplus (Acari: Ixodidae)

Acaricidal and repellent activities of ethanol extracts of nine chinese medicinal herbs against Rhipicephalus microplus (Acari: Ixodidae)

Oxidative biotransformation of stemofoline alkaloids

Isolation and Bioactivities of Stemona Alkaloid: A Review

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