Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy

Praveen, M. Ajanth; Parvathy, K.; Patra, Srimanta; Khan, Md. Imran; Natarajan, Pradeep; Balasubramanian, P.

doi:10.1016/j.ijbiomac.2020.03.086

Cited by 19 publications

(9 citation statements)

References 32 publications

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“…Their results showed ZDock scores of sulfated derivatives that were lower than those of GLPs; they also reported sulfate derivatives to take on random coil during MD simulation, indicating that the sulfate derivatives may have weaker binding with BAS. Praveen et al discovered that carrageenan from Indian seaweeds had the highest affinity for the M3 muscarinic acetylcholine receptor, with a binding energy of −31.27 kcal/mol; in addition, carrageenan was able to form three hydrogen bonds with Ser-151 and Asn-507. Generally, there are five interaction forces, as shown in Figure , i.e., hydrogen bonds, hydrophobicity, π–π stacking, π–cation interactions, and salt bridges, which frequently appear in food component interactions.…”

Section: Molecular Dockingmentioning

confidence: 99%

Application of Molecular Simulation Methods in Food Science: Status and Prospects

et al. 2023

J. Agric. Food Chem.

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Molecular simulation methods, such as molecular docking, molecular dynamic (MD) simulation, and quantum chemical (QC) calculation, have become popular as characterization and/or virtual screening tools because they can visually display interaction details that in vitro experiments can not capture and quickly screen bioactive compounds from large databases with millions of molecules. Currently, interdisciplinary research has expanded molecular simulation technology from computer aided drug design (CADD) to food science. More food scientists are supporting their hypotheses/results with this technology. To understand better the use of molecular simulation methods, it is necessary to systematically summarize the latest applications and usage trends of molecular simulation methods in the research field of food science. However, this type of review article is rare. To bridge this gap, we have comprehensively summarized the principle, combination usage, and application of molecular simulation methods in food science. We also analyzed the limitations and future trends and offered valuable strategies with the latest technologies to help food scientists use molecular simulation methods.

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Section: Molecular Dockingmentioning

confidence: 99%

Application of Molecular Simulation Methods in Food Science: Status and Prospects

et al. 2023

J. Agric. Food Chem.

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“…Praveen et al developed raindrop candy consisting of polysaccharides extracted from Indian seaweed ( S. wightii, E. compressa , and A. spicifera ) and probiotic species L. plantarum NCIM 2083. These seaweed polysaccharides demonstrated anti-cancer effects on RAW 264.7 macrophage and HT-29 human colon cancer cell line in vitro ( 121 ). Thus, synbiotics could be novel therapeutic approaches to strengthen the gut microbiome for protective effects against CRC through alleviating inflammation and preventing tumorigenesis.…”

Section: The Effects Of Dietary Interventions On Colorectal Cancermentioning

confidence: 99%

Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer

et al. 2021

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Dietary factors have important role in modulating the gut microbiome, which in-turn regulates the molecular events in colonic mucosa. The composition and resulting metabolism of the gut microbiome are decisive factors in colorectal cancer (CRC) tumorigenesis. Altered gut microbiome is associated with impaired immune response, and the release of carcinogenic or genotoxic substances which are the major microbiome-induced mechanisms implicated in CRC pathogenesis. Diets low in dietary fibers and phytomolecules as well as high in red meat are important dietary changes which predispose to CRC. Dietary fibers which reach the colon in an undigested form are further metabolized by the gut microbiome into enterocyte friendly metabolites such as short chain fatty acid (SCFA) which provide anti-inflammatory and anti-proliferative effects. Healthy microbiome supported by dietary fibers and phytomolecules could decrease cell proliferation by regulating the epigenetic events which activate proto-oncogenes and oncogenic pathways. Emerging evidence show that predominance of microbes such as Fusobacterium nucleatum can predispose the colonic mucosa to malignant transformation. Dietary and lifestyle modifications have been demonstrated to restrict the growth of potentially harmful opportunistic organisms. Synbiotics can protect the intestinal mucosa by improving immune response and decreasing the production of toxic metabolites, oxidative stress and cell proliferation. In this narrative review, we aim to update the emerging evidence on how diet could modulate the gut microbial composition and revive colonic epithelium. This review highlights the importance of healthy plant-based diet and related supplements in CRC prevention by improving the gut microbiome.

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“…A new symbiotic combination of Lactobacillus gasseri 505 and Cudrania tricuspidata leaf extract in fermented milk has been shown to decrease Staphylococcus and increase Lactobacillus, Bifidobacterium, and Akkermansia in the gut microbiota, thus increasing protective effects in DSS/azoxymethane (AOM) induced colitis-CRC model mice. This in vivo intervention decreased tumor proliferation and inflammation (marked by decreased levels of TNF-α, interferon (IFN)-γ, IL-1β, IL-6, inducible nitric oxide synthase and cyclooxygenase-2) and lead to upregulation of anti-inflammatory cytokines IL-4 and IL-10 [87]. Thus, synbiotics could be novel therapeutic measures to strengthen the gut microbiome and potentially mitigate CRC by alleviating inflammation and preventing tumorigenesis.…”

Section: The Effects Of Dietary Interventions On Colorectal Cancermentioning

confidence: 99%

Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer

Appunni¹,

Rubens²,

Ramamoorthy³

et al. 2021

Preprint

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Dietary factors play an important role in shaping the gut microbiome which, in turn, regulates the molecular events in colonic mucosa. The composition and resulting metabolism of the gut microbiome have been implicated in the development of colorectal cancer (CRC). Diets low in dietary fibers and phytomolecules as well as other lifestyle-related factors may predispose to CRC. Emerging evidence demonstrates that the predominance of microbes, such as Fusobacterium nucleatum, can predispose the colonic mucosa to malignant transformation. Dietary and lifestyle modifications have been demonstrated to restrict the growth of potentially harmful opportunistic organisms. In this study, we aim to present evidence regarding the relationship of dietary factors to the gut microbiome and development of CRC.

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Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy

Cited by 19 publications

References 32 publications

Application of Molecular Simulation Methods in Food Science: Status and Prospects

Application of Molecular Simulation Methods in Food Science: Status and Prospects

Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer

Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer

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