Cytotoxic and Proapoptotic Effects of Resveratrol in In Vitro Studies on Selected Types of Gastrointestinal Cancers

Abstract

Cancer diseases are currently one of the greatest health challenges in clinical medicine worldwide. Classic methods of treatment often lead to numerous side effects, including the development of multidrug resistance. For this reason, increasing hope is being placed on compounds of natural origin, mainly due to their pleiotropic effect on different types of cells, protective effect on normal cells and toxic effect on cancerous ones. The most studied group are the polyphenolic compounds, which include resveratrol. The effectiveness of polyphenols in the treatment and prevention of many diseases, including cancer of various origins, has become the basis of many scientific studies. The anticancer effect of resveratrol has been demonstrated at all stages of the carcinogenesis process. Additionally, whether administered by itself or in combination with cytostatics, it may play a significant role in the process of reversing multidrug resistance. A review of the effects of resveratrol in in vitro conditions proves that it has a stronger or weaker antiproliferative and proapoptotic effect on the cells of certain neoplasms of the gastrointestinal tract. Despite the differences in the effect of this compound on different types of cancer, a similar tendency can be observed especially regarding the correlation between the concentration of the compound and the incubation time on the one hand and the antitumour effect on the other hand. The information included in this review may prove helpful in planning in vivo and clinical studies in the future.

Berberine and Oligomeric Proanthocyanidins Exhibit Synergistic Efficacy Through Regulation of PI3K-Akt Signaling Pathway in Colorectal Cancer

“…Actually, 75 of 175 small molecules recognized as anti-cancer drugs currently, can be traced back to their origin to naturally-occurring botanicals, from 1981 to 2019 ( 64 ). Furthermore, several natural compounds have recently gained increasing attention due to their anti-cancer potential through their ability to target multiple oncogenic pathways, in a safe manner ( 13 – 16 , 65 , 66 ). Among this list of many such compounds including curcumin, boswellia, resveratrol and andrographis, BBR and OPCs have recently been interrogated due to their promising anti-tumorigenic properties in CRC ( 30 , 32 , 33 , 35 – 37 ).…”

Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury

“…It can also be found in red wine, peanuts, and grape skins. A growing body of evidences indicate that RES plays an important role in the treatment and prevention of different diseases, including cancer, cardiovascular diseases, obesity and age-related diseases (Fraiz et al, 2021;Ratajczak and Borska, 2021). Li et al found that RES significantly attenuates obesity-associated early podocyte injury through improving lipid metabolism and insulin sensitivity, as well as inhibiting inflammatory responses in rats induced by an ovariectomy with a HFD (Li B. et al, 2020).…”

Hypoxia, but Not Normoxia, Reduces Effects of Resveratrol on Cisplatin Treatment in A2780 Ovarian Cancer Cells: A Challenge for Resveratrol Use in Anticancer Adjuvant Cisplatin Therapy

“…Its biological activities, including its antioxidant properties, make it potentially useful not only against cancers, but also against cardiac, Alzheimer’s, Parkinson’s and metabolic diseases such as diabetes [ 14 , 15 ]. Widely documented in cancer and leukemia treatments [ 16 ], Res affects three stages of carcinogenesis [ 17 ], modulates signal transduction controlling cell division and growth, and as such, it should inhibit tumor cell proliferation, adhesion, invasion, metastasis and reduce inflammation [ 18 , 19 , 20 ]. Res is an antioxidant, inhibiting the production of reactive oxygen species (ROS), suppressing cyclooxygenase action, and modulating the cell cycle, apoptosis, and inflammation [ 18 , 21 , 22 , 23 , 24 ].…”