Cytotoxic, antibacterial and nucleic acid interaction studies of square planar palladium(II) complexes

Patel, Mohan N.; Patidar, Anshul P.; Karia, Parag S.; Vekariya, Pankaj A.

doi:10.1016/j.ica.2014.04.037

Cited by 9 publications

(5 citation statements)

References 46 publications

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“…The experimental procedure was carried out according to a reported method . A plot of log of sample concentration versus percentage of mortality was shown to have a linear relationship and LC 50 of compounds were calculated from the plot, and found to be in the range 8.23–11.48 μg mL −1 (Supplementary material 10), which was comparable with that reported for Pd(II) complexes (LC 50 = 6.83–15.93 μg mL −1 ) . From the data recorded, complex 7c is the most potent amongst all compounds.…”

Section: Resultssupporting

confidence: 59%

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

et al. 2019

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Novel palladium(II) complexes (7a–7e) of substituted quinoline derivatives were synthesized. The complexes were characterized using various techniques such as thermogravimetric analysis (TGA), elemental analysis, conductance measurement, mass, absorption, infra‐red (IR), 1H NMR, 13C NMR and energy‐dispersive X‐ray spectroscopy (EDX). Complexes for herring sperm DNA (HS DNA) binding were explored and absorption titration and the binding constant (Kb) as well as Gibb's free energy were evaluated. Complex 7d exhibited the highest binding constant, therefore the thermodynamic parameters of 7d at different temperatures were evaluated. To support the results of the absorption titration, fluorescence titration, viscosity measurement and molecular docking studies were performed. The fluorescence quenching data as evaluated from Stern–Volmer equation were used to calculate KSV, Kf and the number of binding sites. The results of all these studies were in good agreement with the absorption study. DNA electrophoretic mobility was performed to explore the possible application of metal complexes as artificial metallonucleases. The antibacterial activity of the complexes was accessed against different pathogenic bacteria and cytotoxicity was measured using brine shrimp and S. pombe.

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Section: Resultssupporting

confidence: 59%

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

et al. 2019

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“…A plot of log of sample concentration versus percentage of mortality has shown the linear relationship and the LC 50 value of compounds have been calculated from the plot. The LC 50 values of the compounds are in the range of 5.93 to 17.81 (supplementary material 7), which is comparable to cytotoxicity of reported Pd (II) complexes (LC 50 = 6.83–15.93μgmL −1 ) . The degree of mortality is directly proportional to the concentration of synthesized compounds.…”

Section: Resultssupporting

confidence: 73%

Synthesis, characterization and biological applications of some substituted pyrazoline based palladium (II) compounds

Thakor

Lunagariya

Bhatt

et al. 2018

Applied Organom Chemis

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Palladium (II) complexes of the type [PdLCl 2 ] (where L = substituted pyrazoline ligands) have been synthesized. The metal complexes (5a-5f) have been characterized by various spectroscopic and analytical techniques like 1 H-NMR, 13 C-NMR, LC-MS, IR, Energy-dispersive X-ray (EDX), electronic spectroscopy, thermogravimetric analysis (TGA), elemental analysis and conductance measurement. Complexes to herring sperm DNA (HS-DNA) binding has been explored by absorption titration and binding constant (K b ) as well as Gibb's free energy have been evaluated. Complex 5b shows the highest binding constant value. So, thermodynamic parameters of 5b-HS DNA complex at different temperature have been evaluated. Also, Viscosity measurement and molecular modeling studies have been performed to know the binding mode of complexes. Based on the observations, an intercalative binding mode of DNA has been proposed. Further confirmation of intercalative mode of DNA binding has been taken by fluorescence spectroscopy and results are in a good agreement with absorption titration, viscosity measurement and molecular modeling data. Antibacterial activity of the complexes has been screened against pathogenic bacteria such as S. aureus, E. coli, B. subtilis, S. marcescens and P. aeruginosa. Cytotoxicity is performed on brine shrimp and S. pombe. Gel electrophoresis assay demonstrates that all the complexes can cleave the pUC19 plasmid DNA. Anti-tuberculosis activity has been carried out using mycobacterium tuberculosis H 37 Rv bacteria by L.J. Medium conventional method.

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“…When PEG-400 was added to the DMSO-d6 solution of 2g, the chemical shifts of phenyl C-H of 2a were all moved to upfield (see the supporting information). This finding implies that PEG-400 can activate organoboronic acid, which may explain the substoichiometric base enabling the transformation with good efficacy in the present catalytic Based on the above results and previous studies, 4,6,12 a possible reaction pathway was proposed in Scheme 3. Initially, an active Pd 0 is in-situ generated from the reduction of Pd II by PEG, 12 followed by oxidative addition of aryl iodide to give an organopalladium complex I.…”

Section: Accepted Manuscriptsupporting

confidence: 69%

“…This finding implies that PEG-400 can activate organoboronic acid, which may explain the substoichiometric base enabling the transformation with good efficacy in the present catalytic Based on the above results and previous studies, 4,6,12 a possible reaction pathway was proposed in Scheme 3. Initially, an active Pd 0 is in-situ generated from the reduction of Pd II by PEG, 12 followed by oxidative addition of aryl iodide to give an organopalladium complex I. Then, I undergoes the insertion of CO to afford an acyl intermediate II, which further reacts with vinylboronic acid under the assistance of a base and PEG to afford an organopalladium species III.…”

Section: Accepted Manuscriptsupporting

confidence: 69%

Ligand-Free Palladium-Catalyzed Substoichiometric Base Mediated Carbonylation of Aryl Iodides with Alkenylboronic Acids under Ambient Conditions

Tang

Gao

Chen

et al. 2023

Synlett

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A highly efficient, practical, and ligand-free palladium-catalyzed carbonylation of aryl iodides with alkenylboronic acids has been developed. A variety of chalcones and ɑ-branched enones were isolated in satisfactory to good yields with good substrates compatibilities under ambient pressure of CO and room temperature. Moreover, a substoichiometric amount of base renders the transformation to proceed well. The merit of this strategy as a late-stage functionalization platform has been demonstrated by the modification of an estrone- and a 3-phenyl-L-alanine -derived complex substrates.

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Cytotoxic, antibacterial and nucleic acid interaction studies of square planar palladium(II) complexes

Cited by 9 publications

References 46 publications

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

Synthesis, characterization and biological applications of some substituted pyrazoline based palladium (II) compounds

Ligand-Free Palladium-Catalyzed Substoichiometric Base Mediated Carbonylation of Aryl Iodides with Alkenylboronic Acids under Ambient Conditions

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Cytotoxic, antibacterial and nucleic acid interaction studies of square planar palladium(II) complexes

Cited by 9 publications

References 46 publications

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

Synthesis, characterization and biological applications of some substituted pyrazoline based palladium (II) compounds

Ligand-Free Palladium-Catalyzed Substoichiometric Base ­Mediated Carbonylation of Aryl Iodides with Alkenylboronic Acids under Ambient Conditions

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Ligand-Free Palladium-Catalyzed Substoichiometric Base Mediated Carbonylation of Aryl Iodides with Alkenylboronic Acids under Ambient Conditions