Cytotoxic benzophenone and triterpene from Garcinia hombroniana

Jamila, Nargis; Khairuddean, Melati; Yaacob, Nik Soriani; Kamal, Nik Nur Syazni Nik Mohamed; Osman, Hasnah; Khan, Sadiq Noor; Khan, Naeem

doi:10.1016/j.bioorg.2014.04.003

Cited by 28 publications

(28 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another benzophenone derived from the Malaysian G. hombroniana, 2,3′,4,5’-tetrahydroxy-6-methoxybenzophenone, has also presented cytotoxic effects on the DBTRG cell line which is derived from a 56-year-old woman with GBM. Most interestingly, the compound was found to be more toxic towards glioma cells as compared to other cell lines of different origin including MCF-7 (breast cancer), U2OS (osteosarcoma) and PC-3 (prostate cancer) [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Anticancer activity of 7-epiclusianone, a benzophenone from Garcinia brasiliensis, in glioblastoma

Sales

Pezuk

Borges

et al. 2015

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundGlioblastoma is the most common tumor of the central nervous system and one of the hardest tumors to treat. Consequently, the search for novel therapeutic options is imperative. 7-epiclusianone, a tetraprenylated benzophenone isolated from the epicarp of the native plant Garcinia brasiliensis, exhibits a range of biological activities but its prospect anticancer activity is underexplored. Thus, the aim of the present study was to evaluate the influence of 7-epiclusianone on proliferation, clonogenic capacity, cell cycle progression and induction of apoptosis in two glioblastoma cell lines (U251MG and U138MG).MethodsCell viability was measured by the MTS assay; for the clonogenic assay, colonies were stained with Giemsa and counted by direct visual inspection; For cell cycle analysis, cells were stained with propidium iodide and analyzed by cytometry; Cyclin A expression was determined by immunoblotting; Apoptotic cell death was determined by annexin V fluorescein isothiocyanate labeling and Caspase-3 activity in living cells.ResultsViability of both cell lines was drastically inhibited; moreover, the colony formation capacity was significantly reduced, demonstrating long-term effects even after removal of the drug. 7-epiclusianone treatment at low concentrations also altered cell cycle progression, decreased the S and G2/M populations and at higher concentrations increased the number of cells at sub-G1, in concordance with the increase of apoptotic cells.ConclusionThe present study demonstrates for the first time the anticancer potential of 7-epiclusianone against glioblastoma cells, thus meriting its further investigation as a potential therapeutic agent.

show abstract

Section: Resultsmentioning

confidence: 99%

Anticancer activity of 7-epiclusianone, a benzophenone from Garcinia brasiliensis, in glioblastoma

Sales

Pezuk

Borges

et al. 2015

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…Tewtraku, 2009) serta tiga belas senyawa yang diketahui yang dikarakterisasi dengan teknik spektral NMR, UV, IR dan EI / ESI-MS. Senyawa 2,3 ',4, .Hasil menunjukan penghambatan pada lini sel kanker DBTRG senyawa (1) 48 μM senyawa (2) 34 μM. Sedangkan selain lini sel kanker DBTRG mempunyai nilai EC 50 yang lemah (Jamila, 2014) Kesimpulan Berdasarkan hasil dari berbagai jurnal yang di review, diketahui bahwa Garcinia Celebica mempunyai aktivitas sitoktosik dalam berbagai sel kanker diantaranya MCF-7 (kanker payudara), A549 (kanker paru), Hela (kanker servik), KB (karsinoma epidermoid), B16F10 (melanoma), DBTRG (glioma). Sehingga perlu dilakukan penelitian lebih lanjut untuk mengetahui mekanisme antikanker tanaman G. Celebica.…”

Section: Aktivitas Sitoktosik Isolat G Hombroniana Pada Sel Kanker Dunclassified

REVIEW ARTICLE : AKTIVITAS SITOKTOSIK MANGGU LEWEUNG (Garcinia celebica L.) PADA BERRBAGAI LINI SEL KANKER

Triyasa

Diantini

Barliana

2020

View full text Add to dashboard Cite

Kanker merupakan penyakit yang mengancam jiwa yang sangat serius bagi semua manusia. Menurut data GLOBOCAN 2018 kasus populasi kanker masih meningkat menjadi 18,1 juta dan 9,6 juta dan kematian dan hampir dari setengah populasi terjadi di Asia. Ekstrak, fraksi hingga isolat Garcinia Celebica (manggis hutan) dilaporkan mempunyai aktivitas sitoktosik yang dapat menghambat pertumbuhan dalam berbagai sel kanker diantaranya MCF-7 (kanker payudara), A549 (kanker paru), Hela (kanker servik), KB (karsinoma epidermoid), B16F10 (melanoma), DBTRG (glioma).

show abstract

“…The fruits, leaves, flowers, stem and bark of Garcinia species have been used traditionally to treat abdominal pain, dysentery, diarrhoea, suppuration, infections, leucorrhoea, chronic ulcer and gonorrhoea (Braide 1993;Moongkarndi et al 2004;Balemba et al 2010). Phytochemical investigation of Garcinia species revealed the isolation of xanthones, benzophenones, flavonoids, biflavonoids and triterpenes (Hiroyuki et al 1996;Rukachaisirikul et al 2000Rukachaisirikul et al , 2003Rukachaisirikul et al , 2005Klaiklay et al 2013;, Jamila, Khairuddean, Yaacob, et al 2014 showing significant antimicrobial, antioxidant, cytotoxic, anti-inflammatory, antitumor, antiulcer and antiplasmodial activities (Gustafson et al 1992;Sang et al 2002;Ito et al 2003;Matsumoto et al 2003;Jayaprakasha et al 2006;Mahabusarakam et al 2006;Franklin et al 2009). Natural triterpenes have shown potent antimicrobial, anti-inflammatory, anticarcinogenic, hepatoprotective, hypolipidaemic and anti-HIV activities (Rios et al 2000;Takao & Midori 2000;Dzubak et al 2006).…”

Section: Introductionmentioning

confidence: 97%

“…Previous phytochemical and pharmacological investigation on G. hombroniana resulted in the isolation of xanthones, benzophenones, flavonoids and triterpenes with cytotoxic, anticholinesterase, low density lipoprotein antioxidation and antiplatelet aggregation activities (Rukachaisirikul et al 2000(Rukachaisirikul et al , 2003(Rukachaisirikul et al , 2005Saputri & Jantan 2012;Klaiklay et al 2013;. Previous phytochemical investigation on the bark of G. hombroniana afforded cholinesterase inhibitory and cytotoxic triterpenoidal constituents (Jamila, Khairuddean, Yaacob, et al 2014;. In our continued research, an investigation was undertaken on the dichloromethane bark extract of G. hombroniana which led to the isolation of one new cycloartane triterpene; (22Z,24E)-3β-hydroxycycloart-14,22,24-trien-26-oic acid (1)shown in Figure 1.…”

Section: Introductionmentioning

confidence: 98%

A bioactive cycloartane triterpene from Garcinia hombroniana

Jamila

Khan

et al. 2015

Natural Product Research

Self Cite

View full text Add to dashboard Cite

The dichloromethane bark extract of Garcinia hombroniana yielded one new cycloartane triterpene; (22Z,24E)-3β-hydroxycycloart-14,22,24-trien-26-oic acid (1) together with five known compounds: garcihombronane G (2), garcihombronane J (3), 3β acetoxy-9α-hydroxy-17,14-friedolanostan-14,24-dien-26-oic acid (4), (22Z, 24E)-3β, 9α-dihydroxy-17,14-friedolanostan-14,22,24-trien-26-oic acid (5) and 3β, 23α-dihydroxy-17,14-friedolanostan-8,14,24-trien-26-oic acid (6). Their structures were established by the spectral techniques of NMR and ESI-MS. These compounds together with some previously isolated compounds; garcihombronane B (7), garcihombronane D (8) 2,3',4,5'-tetrahydroxy-6-methoxybenzophenone (9), volkensiflavone (10), 4''-O-methyll-volkensiflavone (11), volkensiflavone-7-O-glucopyranoside (12), volkensiflavone-7-O-rhamnopyranoside (13), Morelloflavone (14), 3''-O-methyl-morelloflavone (15) and morelloflavone-7-O-glucopyranoside (16) were evaluated for cholinesterase enzymes inhibitory activities using acetylcholinesterase and butyrylcholinesterase. In these activities, compounds 1-9 showed good dual inhibition on both the enzymes while compounds 10-16 did not reasonably contribute to both the cholinesterases inhibitory effects.

show abstract

Cytotoxic benzophenone and triterpene from Garcinia hombroniana

Cited by 28 publications

References 30 publications

Anticancer activity of 7-epiclusianone, a benzophenone from Garcinia brasiliensis, in glioblastoma

Anticancer activity of 7-epiclusianone, a benzophenone from Garcinia brasiliensis, in glioblastoma

REVIEW ARTICLE : AKTIVITAS SITOKTOSIK MANGGU LEWEUNG (Garcinia celebica L.) PADA BERRBAGAI LINI SEL KANKER

A bioactive cycloartane triterpene from Garcinia hombroniana

Contact Info

Product

Resources

About