Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri

Ankli, Anita; Heilmann, Jörg; Heinrich, Michael; Sticher, Otto

doi:10.1016/s0031-9422(00)00144-8

Cited by 57 publications

(37 citation statements)

References 20 publications

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“…Celastrol (65) was toxic to several human cancer cell lines (Kutney et al, 1981a;Figueiredo et al, 1998;González et al, 1998;Ankli et al, 2000;Zhou et al, 2002;Lee et al, 2004) and inhibited TPA-induced EBV-EA . Pristimerin (64) and tingenone (66) were also toxic to numerous cancer cell lines (Gonzalez et al, 1977;Kutney et al, 1981a,b;Itokawa et al, 1991;Ngassapa et al, 1994;Shirota et al, 1994;Figueiredo et al, 1998;González et al, 1998;Setzer et al, 1998Setzer et al, , 2001Lee et al, 2004).…”

Section: Cancermentioning

confidence: 99%

“…Pristimerin (64) and tingenone (66) were also toxic to numerous cancer cell lines (Gonzalez et al, 1977;Kutney et al, 1981a,b;Itokawa et al, 1991;Ngassapa et al, 1994;Shirota et al, 1994;Figueiredo et al, 1998;González et al, 1998;Setzer et al, 1998Setzer et al, , 2001Lee et al, 2004). 22β-Hydroxy-tingenone (67) was about as cytotoxic as 64 and 66 (Kutney et al, 1981b;Bavovada et al, 1990;Itokawa et al, 1991;Shirota et al, 1994;Sattar et al, 1998;, which were generally more toxic than 65 (Ngassapa et al, 1994;Ankli et al, 2000;Chang et al, 2003).…”

Section: Cancermentioning

confidence: 99%

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Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

et al. 2007

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Plants in the genus Tripterygium, such as Tripterygium wilfordii Hook. f., have a long history of use in traditional Chinese medicine. In recent years there has been considerable interest in the use of Tripterygium extracts and of the main bioactive constituent, the diterpene triepoxide triptolide (1), to treat a variety of autoimmune and inflammation-related conditions. The main mode of action of the Tripterygium extracts and triptolide (1) is the inhibition of expression of proinflammatory genes such as those for interleukin-2 (IL-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2) and interferon-gamma (IFN-γ). The efficacy and safety of certain types of Tripterygium extracts were confirmed in human clinical trials in the US and abroad. Over 300 compounds have been identified in the genus Tripterygium, and many of these have been evaluated for biological activity. The overall activity of the extract is based on the interaction between its components. Therefore, the safety and efficacy of the extract cannot be fully mimicked by any individual constituent. This review discusses the biochemical composition and biological and pharmacological activities of Tripterygium extracts, and their main bioactive components.

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Section: Cancermentioning

confidence: 99%

Section: Cancermentioning

confidence: 99%

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

et al. 2007

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“…A further search for structurally interesting and bioactive compounds from this plant resulted in the isolation of the new phenolic triterpenes isoblepharodol (1), 7-oxo blepharodol (2), blepharotriol (3), and 6-deoxoblepharodol (4), together with the known phenolic triterpenes 6-oxopristimerol, 8 7-hydroxy-6-oxopristimerol, 9 demethyl zeylasteral and demethylzeylasterone. 10 Their structures were determined by spectroscopic methods, including 1 H-13 C heteronuclear correlation (HSQC), long-range correlation with inverse detection (HMBC), and ROESY NMR experiments.…”

Section: Introductionmentioning

confidence: 99%

New phenolic triterpenes from Maytenus blepharodes. Semisynthesis of 6-deoxoblepharodol from pristimerin

et al. 2005

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“…Because tannins are polyphenolic compounds. This was confirmed by Harbourne, 18,19 classic way to detect simple phenol extract is added to a solution of FeCl3 1% in water, which cause the color green, red, purple, blue and black strong. Formation of green or blue-black ink on the extract after added with FeCl3 1% as tannins will form complexes with Fe 3+ ions.…”

Section: Results and Discussion Phytochemical Testsmentioning

confidence: 75%

“…This result indicates there are present of tannin. Tannins can be used as an antibacterial because it has a phenol group, so that the tannins have properties like alcohol is an antiseptic that can be used as an antimicrobial component 18 . These experiments show that the extract being extracted does contain antibacterial properties and can be used to formulate the antibacterial cream.…”

Section: Results and Discussion Phytochemical Testsmentioning

confidence: 99%

Cinnamon Bark Extract for the Formulation and Characterisation of Antimicrobial Cream

Suliman¹,

Ali²,

Nurulain³

et al. 2017

Int. J. Res. Ayurveda Pharm.

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The main objective of this study was to formulate a stable W/O cream containing different strength of methanolic Cinnamomum cassia extract. It is known that the methanolic extract has an antibacterial activity and antioxidant, anticancer, antidiabetic and anti-cholesterol properties. Dried cinnamon bark was collected from Shah Alam, Malaysia during February 2014 and authenticated at Botany department at University Putra Malaysia. The dried barks were grinded to powder and used for extraction using maceration method. The extract was assessed for antibacterial properties. Then, a set of creams were prepared from the extract in different compositions to the formulations and stored at different accelerated conditions for a period of four weeks to predict the stability of these creams. Evaluation of creams was based on the physical stability, phase separation, centrifugation, pH of the formulations and test for microbial growth in formulated creams parameters. The result of the study showed significant changes in the pH of all creams in temperature above 25 °C and insignificant changes in temperature below 25°C with the passage of time. Great stability was observed in the formulations in term of phase separation, liquefaction, and color. The pH of all the formulations was 5.9-6.36, which is comparable to the 5-7 pH level of the skin. All these formulations showed no phase separation and color change during the test period, except for cream with 4%. From the present study, it can be concluded that it is possible to develop creams containing Cinnamomum cassia herbal extracts with a good antibacterial property.

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Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri

Cited by 57 publications

References 20 publications

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

New phenolic triterpenes from Maytenus blepharodes. Semisynthesis of 6-deoxoblepharodol from pristimerin

Cinnamon Bark Extract for the Formulation and Characterisation of Antimicrobial Cream

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