Cytotoxic cardenolides from Calotropis gigantea

Yang, Hyejin; Huang, Pei-Zhi; Feng, Wei-Jiao; Gao, Kun

doi:10.1016/j.phytochem.2021.112951

Cited by 11 publications

(5 citation statements)

References 22 publications

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“…Hence, targeting TP53 presents a promising strategy to address the poor therapeutic response in glioblastoma [ 24 ]. The preferential cytotoxicity of C. procera leaves crude extract towards U251 cells (this study) and Calotropin [ 37 ] indicates its beneficial therapeutic effect towards TP53 mutated glioblastoma.…”

Section: Discussionmentioning

confidence: 97%

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Calotropis procera: A double edged sword against glioblastoma, inhibiting glioblastoma cell line growth by targeting histone deacetylases (HDAC) and angiogenesis

Saleh Alanazi,

Farooq Khan,

Alazami

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 97%

“…The scientific literature regarding the anticancer potential of C. procera against glioblastoma is scarce. The cytotoxicity of calotropin in A172 and U251 glioblastoma cells has been reported quite recently [ 37 ]. Calotropin is a pharmacologically active substance discovered in milkweed plants like C. procera and C. gigantea .…”

Section: Discussionmentioning

confidence: 99%

Calotropis procera: A double edged sword against glioblastoma, inhibiting glioblastoma cell line growth by targeting histone deacetylases (HDAC) and angiogenesis

Saleh Alanazi,

Farooq Khan,

Alazami

et al. 2024

Heliyon

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“…A recent study investigated several types of cardiac glycosides isolated from Calotropis gigantea and showed that calotropin had the most pronounced cytotoxicity on A172 and U251 glioblastoma cell lines, and confirmed a possible anticancer mechanism that includes G2/M phase cell arrest (He et al, 2021). Another evidence that calotropin may have cytotoxic effects on cancer cell lines derives from its capability to inhibit the enzyme Na + /K + -ATPase.…”

Section: Therapeutic Activity Cellular and Molecular Mechanisms Of Ca...mentioning

confidence: 90%

An updated pharmacological insight into calotropin as a potential therapeutic agent in cancer

et al. 2023

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Calotropin is a pharmacologically active compound isolated from milkweed plants like Calotropis procera, Calotropis gigantea, and Asclepias currasavica that belong to the Asclepiadaceae family. All of these plants are recognised as medical traditional plants used in Asian countries. Calotropin is identified as a highly potent cardenolide that has a similar chemical structure to cardiac glycosides (such as digoxin and digitoxin). During the last few years, cytotoxic and antitumor effects of cardenolides glycosides have been reported more frequently. Among cardenolides, calotropin is identified as the most promising agent. In this updated and comprehensive review, we aimed to analyze and discuss the specific mechanisms and molecular targets of calotropin in cancer treatment to open new perspectives for the adjuvant treatment of different types of cancer. The effects of calotropin on cancer have been extensively studied in preclinical pharmacological studies in vitro using cancer cell lines and in vivo in experimental animal models that have targeted antitumor mechanisms and anticancer signaling pathways. The analyzed information from the specialized literature was obtained from scientific databases until December 2022, mainly from PubMed/MedLine, Google Scholar, Scopus, Web of Science, and Science Direct databases using specific MeSH search terms. The results of our analysis demonstrate that calotropin can be a potential chemotherapeutic/chemopreventive adjunctive agent in cancer pharmacotherapeutic management.

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“…Three cardenolide glycosides, namely coroglaucigenin (6), frugoside (7), and 40 befaglucopyranosylfrugoside (8) were isolated as the cytotoxic constituents from the roots of Calotropis gigantic L., often known as "Akond Mul". The study focused on assessing the detrimental impact of these components on the human organism and mouse cell lines [27,28] . The numerical range of the observed selectivity of the cell line showed similarities to the selectivity of cardiopulmonary glycosides, namely digoxin and ouabain.…”

Section: Seedsmentioning

confidence: 99%

Calotropis gigantea: An in-depth review of its therapeutic potential

Dwivedi,

Pratap,

Awasthi

et al. 2024

J Pharmacogn Phytochem

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Background: Calotropis gigantea, belonging to the Asclepiadaceae family, is a perennial herb in question that has been used in the field of traditional medicine for an extensive duration. The botanical specimen in question has been shown to produce a wide array of chemical compounds, including but not limited to cardiac glycosides, flavonoids, terpenoids, alkaloids, tannins, and resins seen in the management of a diverse range of medical conditions, including leprosy, ulcers, tumors, and piles. Objectives: The compounds under investigation exhibit various pharmacological activities, including analgesic, antipyretic, pregnancy interceptive, central nervous system (CNS), anti-inflammatory, procoagulant, anti-diarrheal, free radical scavenging, antimicrobial, anti-tumor, antifungal, antitussive, and antifeedant activities are among the pharmacological activities reported. It is a weed plant usually known as enormous milkweed. It contains one of the most essential traditional remedies for treating various diseases. The primary goal of this research on Calotropis gigantea is a plant that may be identified as an example in this context. The present study investigates the systematic categorization, introduction of plants, investigation of morphological characteristics, composition of phytochemicals, and economic importance of Calotropis gigantea. Calotropis gigantea, a shrub or small tree, has a bare or hoary characteristic and possesses laticiferous properties. It is well recognized by the popular names "swallow-wort" or "milkweed." Calotropis is a botanical species often used in traditional medicine Cardenolides, flavonoids, terpenes, pregnanes, and nonprotein amino acids are chemical components of C. gigantea. The latex, leaves, blossoms, bark, and root are also used as a caustic, acrid, expectorant, depilatory, and anthelmintic, and are beneficial in leprosy, scabies, and ringworm of the scalp, piles, and other conditions. Conclusion:The review focuses on the pharmacokinetic and pharmacotherapeutic approaches of the herbs and primarily studies the parameters hepatic protectant effect of the substance.

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Cytotoxic cardenolides from Calotropis gigantea

Cited by 11 publications

References 22 publications

Calotropis procera: A double edged sword against glioblastoma, inhibiting glioblastoma cell line growth by targeting histone deacetylases (HDAC) and angiogenesis

Calotropis procera: A double edged sword against glioblastoma, inhibiting glioblastoma cell line growth by targeting histone deacetylases (HDAC) and angiogenesis

An updated pharmacological insight into calotropin as a potential therapeutic agent in cancer

Calotropis gigantea: An in-depth review of its therapeutic potential

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