Cytotoxic Compounds From Ludwigia hyssopifolia

Abstract

Purification of the petroleum ether and ethyl acetate fractions from Ludwigia hyssopifolia yielded 9 natural products, ethyl gallate (1), vanillin (2), trans-p-hydroxycinnamic acid (3), trans-p-hydroxy-ethyl cinnamate (4), ozoroalide (5), scopoletin (6), de-O-methyllasiodiplodin (7), syringaldehyde (8), and 3,3′-dimethoxy-4,4′-dihydroxy-stilbene (9). The structures of 1 to 9 were determined by spectroscopic analyses including 1D Nuclear Magnetic Resonance (NMR) ( 1 H NMR and 13 C NMR) and Mass Spectrum (MS) data. Four compounds displayed cytotoxic effects on the human laryngeal cancer Hep-2 cell line. Compounds 5 and 7 were also effective against TU212 cell line and significantly inhibited cancer cell growth in a dose-and time-dependent manner on Hep-2 cell line.

Phytochemical and biological diversity of genus Ludwigia: A comprehensive review

“…Different extracts of L. stolonifera [16,18] Aerial parts ethylacetate and methanolic extracts of L.hyssopifolia [13,14,31] Leaf methanolic extract of L. peploides [30] Ethylacetate and butanol fractions L. octovalvis [9] Anti-inflammatory activity Aerial parts ethylacetate of L. stolonifera.…”