Cytotoxic constituents from <i>Isotrema tadungense</i>

Luu, Hong Truong; Cuong, Nguyen Hieu; Dang, Tran Huu; Hanh, Nguyen Thi; Thi, Vien Le; Hong, Hanh Tran Thi; Quang, Trần Hồng; Nguyen, Hai Dang; Cuong, Nguyen Xuan; Hoai, Nam Nguyen; Minh, Châu Văn

doi:10.1080/10286020.2020.1739661

Cited by 10 publications

(7 citation statements)

References 23 publications

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“…NTCT, NTFT, NTST, a previously undescribed arylbenzofuran rhamnoside named aristolochiaside ( 203 , Figure 14 ) and seven known compounds were isolated from Isotrema tadungense (Aristolochiaceae), from which the extract showed significant cytotoxic activity [ 161 ]. It is a plant essentially distributed in Vietnam.…”

Section: Structure and Biological Activity Of Cinnamoyltyramine Alkylamides And Of Co-metabolites Isolated From The Same Natural Sourcesmentioning

confidence: 99%

“…The already known compounds were identified as aristolactam AIIIa, aristololactam CII, grossamide, cannabisin D, melongenamide, cannabisin F and N - trans -feruloyldopamine. Among the isolated compounds, aristolochiaside, aristolactam AIIIa and NTST showed strong and selective cytotoxicity on the HeLa human cancer cell line with IC 50 values of 7.59 ± 1.03, 8.51 ± 1.73 and 9.77 ± 1.25 μM, respectively [ 161 ].…”

Section: Structure and Biological Activity Of Cinnamoyltyramine Alkylamides And Of Co-metabolites Isolated From The Same Natural Sourcesmentioning

confidence: 99%

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Natural Bioactive Cinnamoyltyramine Alkylamides and Co-Metabolites

Evidente

Masi

2021

Biomolecules

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Natural products are a vital source for agriculture, medicine, cosmetic and other fields. Among them alkylamides are a broad and expanding group found in at least 33 plant families. Frequently, they possess a simple carbon skeleton architecture but show broad structural variability and important properties such as immunomodulatory, antimicrobial, antiviral, larvicidal, insecticidal and antioxidant properties, amongst others. Despite to these several and promising biological activities, up to today, only two reviews have been published on natural alkylamides. One focuses on their potential pharmacology application and their distribution in the plant kingdom and the other one on the bioactive alkylamides specifically found in Annona spp. The present review is focused on the plant bioactive cinnamoyltyramine alkylamides, which are subject of several works reported in the literature. Furthermore, the co-metabolites isolated from the same natural sources and their biological activities are also reported.

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Section: Structure and Biological Activity Of Cinnamoyltyramine Alkylamides And Of Co-metabolites Isolated From The Same Natural Sourcesmentioning

confidence: 99%

Section: Structure and Biological Activity Of Cinnamoyltyramine Alkylamides And Of Co-metabolites Isolated From The Same Natural Sourcesmentioning

confidence: 99%

Natural Bioactive Cinnamoyltyramine Alkylamides and Co-Metabolites

Evidente

Masi

2021

Biomolecules

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“…A total of nine compounds were detected; two of them were disubstituted, four were trisubstituted, and three were tetrasubstituted. By comparing the retention time, the isolated compounds 1-5 were identified; the other four compounds (6)(7)(8)(9) were not purified due to the low content. The MS and MS/MS data of nine compounds are listed in Table 2.…”

Section: Sfc-ms/ms Characterization Of Phenylamide Compoundsmentioning

confidence: 99%

“…In addition to lignans and neolignans, other kinds of components have been reported in P. kadsura. Phenylamides, also known as phenolamides or phenolic amides, exist extensively in the plant kingdom and garner increasing attention for the bioactive properties of antioxidant, neuroprotective, antiatherosclerosis, antitoxin, and anticancer [2][3][4][5][6]. Phenylamides have also been found in Piper nigrum L. plants [7], and a phenylamide N-trans-p-coumaroyltyramine was discovered in P. kadsura [8].…”

Section: Introductionmentioning

confidence: 99%

Separation and characterization of phenylamides fromPiper kadsurausing preparative supercritical fluid chromatography and ultra‐high‐performance supercritical fluid chromatography‐tandem mass spectrometry

Dai

Jiang

Dai

et al. 2021

J of Separation Science

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A preparative supercritical fluid chromatography method for the separation of Piper kadsura obtained five phenylamide compounds, which had the same structural skeleton, but changed in the number and position of methoxyl substituents. To improve the separation selectivity of these structural analogues, silica, phenyl, and chiral stationary phases were screened. Only through the combination of Chiral C and phenyl columns could the separation of the five phenylamides be solved. The two‐step strategy using preparative supercritical fluid chromatography presented good orthogonality that ensured the purity of the phenylamides. Then, an ultra‐high‐performance supercritical fluid chromatography hyphened tandem mass spectrometry method was developed, and the fragmentation pattern of phenylamides was summarized. It mainly cleaved in the amide bond to produce the fragment ion, which could help to judge the substituent positions. Twenty‐eight possible molecular weights of hydroxyl and methoxyl substituted phenylamides were calculated and screened. Nine compounds were extracted in three [M + H]+ ions at m/z 284.13, 314.13, and 344.13, including five purified compounds and the other four positional or trans‐cis phenylamide isomers in low content. The methods developed in this research were useful in the separation and characterization of phenylamide analogues.

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“…They can be traced to the effects of numerous marine compounds from different classes of constituents such as alkaloids, terpenoids, steroids, flavonoids, peptides, proteins, polyphenols, carotenoids, vitamins, tocopherols, tocotrienols, peptides, carbohydrates, etc. Not only marine compounds, but also terrestrial plant constituents have anticancer properties [ 1 , 2 , 3 , 4 , 5 ], as well as a plethora of other biological activities. The activities of these compounds have been screened in various disease conditions including cancer using in vivo or in vitro methods, and the documented evidence of these activities is reviewed regularly [ 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review

et al. 2021

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Secondary metabolites from marine sources have a wide range of biological activity. Marine natural products are promising candidates for lead pharmacological compounds to treat diseases that plague humans, including cancer. Cancer is a life-threatening disorder that has been difficult to overcome. It is a long-term illness that affects both young and old people. In recent years, significant attempts have been made to identify new anticancer drugs, as the existing drugs have been useless due to resistance of the malignant cells. Natural products derived from marine sources have been tested for their anticancer activity using a variety of cancer cell lines derived from humans and other sources, some of which have already been approved for clinical use, while some others are still being tested. These compounds can assault cancer cells via a variety of mechanisms, but certain cancer cells are resistant to them. As a result, the goal of this review was to look into the anticancer potential of marine natural products or their derivatives that were isolated from January 2019 to March 2020, in cancer cell lines, with a focus on the class and type of isolated compounds, source and location of isolation, cancer cell line type, and potency (IC50 values) of the isolated compounds that could be a guide for drug development.

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Cytotoxic constituents from Isotrema tadungense

Cited by 10 publications

References 23 publications

Natural Bioactive Cinnamoyltyramine Alkylamides and Co-Metabolites

Natural Bioactive Cinnamoyltyramine Alkylamides and Co-Metabolites

Separation and characterization of phenylamides fromPiper kadsurausing preparative supercritical fluid chromatography and ultra‐high‐performance supercritical fluid chromatography‐tandem mass spectrometry

Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review

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