Cytotoxic Constituents from the Leaves of Cinnamomum subavenium

Kuo, Soong-Yu; Hsieh, Tusty‐Jiuan; Wang, Yau-Der; Lo, Wen-Li; Hsui, Yen‐Ray; Chen, Chung‐Yi

doi:10.1248/cpb.56.97

Cited by 60 publications

(31 citation statements)

References 24 publications

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“…Compounds 1 to 4 were characterized by comparison of their spectroscopic data, including NMR, MS, and IR, with literature values (Masatake Niwa, 1975;Hiroyuki Karikome, 1991;Anderson et al, 1992;Kuo et al, 2008).…”

Section: Nmr Characterization Of Natural Compoundsmentioning

confidence: 99%

Obtusilactone B from Machilus Thunbergii Targets Barrier-to-Autointegration Factor to Treat Cancer

Kim

Lyu

Kwon

et al. 2013

Molecular Pharmacology

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Targeting specific molecules is a promising cancer treatment because certain types of cancer cells are dependent on specific oncogenes. This strategy led to the development of therapeutics that use monoclonal antibodies or small-molecule inhibitors. However, the continued development of novel molecular targeting inhibitors is required to target the various oncogenes associated with the diverse types and stages of cancer. Obtusilactone B is a butanolide derivative purified from Machilus thunbergii. In this study, we show that obtusilactone B functions as a small-molecule inhibitor that causes abnormal nuclear envelope dynamics and inhibits growth by suppressing vaccinia-related kinase 1 (VRK1)-mediated phosphorylation of barrier-to-autointegration factor (BAF). BAF is important in maintaining lamin integrity, which is closely associated with diseases that include cancer. Specific binding of obtusilactone B to BAF suppressed VRK1-mediated BAF phosphorylation and the subsequent dissociation of the nuclear envelope from DNA that allows cells to progress through the cell cycle. Obtusilactone B potently induced tumor cell death in vitro, indicating that specific targeting of BAF to block cell cycle progression can be an effective anticancer strategy. Our results demonstrate that targeting a major constituent of the nuclear envelope may be a novel and promising alternative approach to cancer treatment.

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Section: Nmr Characterization Of Natural Compoundsmentioning

confidence: 99%

Obtusilactone B from Machilus Thunbergii Targets Barrier-to-Autointegration Factor to Treat Cancer

Kim

Lyu

Kwon

et al. 2013

Molecular Pharmacology

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“…There is only one paper describing the constituents of Cinnamomum reticulatum Hay [1]. In the course of screening for biologically and chemically novel agents from Formosan Lauraceous plants [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17], C. reticulatum Hay was chosen for further phytochemical investigation. In this paper, we report the isolation and structural elucidation of this new chromanone compound (1).…”

Section: Introductionmentioning

confidence: 99%

(S*)-2,7,8-Trihydroxychroman-4-one

Cheng

Yeh

et al. 2009

Molbank

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“…In the course of screening for biologically and chemically novel agents from Formosan Lauraceous plants [2][3][4][5][6][7][8][9][10][11][12][13][14][15], C. insulari-montanum Hayata was chosen for further phytochemical investigation. In this paper, we reinvestigated the constituents in the stems of C. insulari-montanum Hayata [16][17][18][19][20][21].…”

mentioning

confidence: 99%

Chemical constituents from the stems of Cinnamomum insulari-montanum

Hsieh¹,

Hsieh²,

Chen³

2010

Chem Nat Compd

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547.972Cinnamomum insulari-montanum Hayata (Lauraceae) is an endemic tree that grows in Taiwancs natural hardwood forest at elevations between 400 and 1500 m [1]. In the course of screening for biologically and chemically novel agents from Formosan Lauraceous plants [2][3][4][5][6][7][8][9][10][11][12][13][14][15], C. insulari-montanum Hayata was chosen for further phytochemical investigation. In this paper, we reinvestigated the constituents in the stems of C. insulari-montanum Hayata [16][17][18][19][20][21]. The MeOH extract of its stems was subjected to solvent partitioning and chromatographic separation to afford eight pure substances. The chemical constituents in the stems of C. insulari-montanum Hayata were separated with column chromatography. Seven compounds, including a mixture of E-sitosterol (1) and stigmasterol (2) [22], coumarin (3) [14], cinnamyl alcohol (4) [14], cinnamic acid (5) [14], p-hydroxybenzoic acid (6) [14], kaempferol (7) [15], and kaempferitrin (8) [15], were isolated from the stems of C. insulari-montanum Hayata. All of these compounds were found for the first time in this plant.

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Cytotoxic Constituents from the Leaves of Cinnamomum subavenium

Cited by 60 publications

References 24 publications

Obtusilactone B from Machilus Thunbergii Targets Barrier-to-Autointegration Factor to Treat Cancer

Obtusilactone B from Machilus Thunbergii Targets Barrier-to-Autointegration Factor to Treat Cancer

(S*)-2,7,8-Trihydroxychroman-4-one

Chemical constituents from the stems of Cinnamomum insulari-montanum

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