Cytotoxic constituents from the leaves of Jerusalem artichoke (Helianthus tuberosus L.) and their structure–activity relationships

Yuan, Xiaoyan; Cheng, Mengchun; Gao, Mingzhe; Zhuo, Rongjie; Zhang, Liangxiao; Xiao, Hongbin

doi:10.1016/j.phytol.2012.10.007

Cited by 27 publications

(26 citation statements)

References 15 publications

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“…The results of the study showed that the contents of lactones in the leaves varied significantly in the Jerusalem artichoke from different areas. Bioassay-directed phytochemical study led to the isolation of a number of sesquiterpene lactone of 3-hydroxy-8b-tigloyloxy-1,10-dehydroariglovin, and ten known sesquiterpene lactones (Yuan et al 2013).…”

Section: Stemsmentioning

confidence: 99%

Phytochemicals in bioenergy crops

2019

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The use of natural compounds derived from agricultural crops and other plants as health promoting chemicals gains tremendous growing interest in various industrial sectors as well as among people worldwide. These chemicals have been more and more employed by the food industry as food additives, functional food ingredients, nutraceuticals, by feedstuffs industry, but also by the cosmetic and pharmaceutical industries. The general idea for this interest is to use natural products as potential alternatives to synthetic chemicals. On the other hand, some plants characterized by high yield and being used as energy crops also contained significant amount of bioactive compounds. This review focuses on the wide spectrum of the phytochemicals present in available biomass plants. It is supposed that extraction of bioactive chemicals from energy crops before their energetic use may increase economical effectiveness, providing simultaneously a double benefit in the form of phytochemicals and bioenergy as value added products. This remains in line with bioeconomy, which is defined by European Commission as ''the production of renewable biological resources and the conversion of these resources and waste streams into value added products, such as food, feed, bio-based products and bioenergy''. However, the issue is still a challenging effort due to the high costs, technology readiness and regulatory hurdles.

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Section: Stemsmentioning

confidence: 99%

Phytochemicals in bioenergy crops

2019

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“…In folk medicine, TPB leaves are used for the treatment of bone fractures, skin wounds, swelling and pain [3]. Moreover, a number of bioactive compounds demonstrating antifungal, antioxidant and anticancer activities have been isolated from the aboveground parts of the plant [3,[19][20][21][22][23][24]. Due to the high content of inulin, TPB represents a valuable alternative source of prebiotic compounds [25].…”

mentioning

confidence: 99%

“…Phenolic acid isolated from TPB leaves have antifungal activities [22], while chlorogenic and isochlorogenic acids have good antioxidant properties [20]. Moreover, ethyl acetate has activities against breast cancer, lung cancer and epithelial cervical cancer [21]. In studies carried out by Liu et al [22], the antifungal properties of TPB leaves extracts was studied against several fungi, such as Rhizoctonia solani, Gibberella zeae, Alternaria solani and Botrytis cinerea.…”

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confidence: 99%

Topinambur – new possibilities for use in a supplementation diet

Szewczyk¹,

Zagaja²,

Bryda³

et al. 2019

Ann Agric Environ Med.

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Jerusalem artichoke (Helianthus tuberosus Linne) is a tuberous perennial plant of the Asteraceae family, which originates from North America, and is also known as wild sunflower or topinambur (TPB). It is characterized by good tolerance to frost, drought and poor soil, strong resistance to pests and plant diseases. For ages it was cultivated due to being both an edible tuber and having healing properties. In folk medicine, TPB leaves are used for the treatment of bone fractures and pain. TPB tubers are rich in sugar and have therefore been used for the production of functional food ingredients, such as inulin. Moreover, TPB is one of the potential crops for bioenergy production, such as bioethanol, biobuthanol and biodiesel, and chemicals (lactic acid, butyric acid). A number of bioactive compounds from the above ground parts of this plant have been isolated which have demonstrating antifungal, antioxidant and anticancer activities. In recent years, a number of animal experiments have been carried out to assess the health properties of TPB. Obtained results show that TPB possess a wide spectrum of medical applications, e.g. reduction in the levels of plasma glucose, total cholesterol and triglyceride. Interestingly, TPB has been shown to be a valuable alternative source of prebiotic compounds. This review article presents recent scientific reports on the chemical and biological properties of TPB and its potential use as a prebiotic diet supplement.

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“…Two Jerusalem artichoke chemotypes were found: one was characterised by dominance of 1,10-epoxidised heliango lides and the other by 1-keto-2,3-unsaturated-furanoheliangolides; a total of 19 such sesquiterpene lactones were found in the leaf capitate glandular trichomes (Spring 1991 ); 7 chlorogenic acids comprise three caffeoylquinic acids, one feruloylquinic acid and three dicaffeoylquinic acids (Yuan et al 2008c (Choi et al 2012 ). Eleven sesquiterpene lactones including a new sesquiterpene lactone of 3-hydroxy-8β-tigloyloxy-1, 10-dehydroariglovin and two known fl avones were isolated from the leaves (Yuan et al 2013 ).…”

Section: Leaf Phytochemicalsmentioning

confidence: 99%

“…Of the four cytotoxic sesquiterpene lactones isolated from the extract, Δ 4,15 -isoatripliciolide tiglate showed the most potent cytotoxic activity (0.26 μM < ED 50 <2.16 μM) against all of the cell lines tested. Eleven sesquiterpene lactones isolated from leaves exhibited cytotoxicity against MCF-7, A549 and HeLa cancer cells lines, while two isolated fl avones showed selective inhibitory activity against HeLa cell lines (Yuan et al 2013 ). Among them compound 3 exhibited signifi cant growth inhibitory activity against all three cell lines and the IC 50 values of compound 3 against MCF-7, A549 and HeLa were 1.97, 7.79 and 9.87 μg/ml, respectively.…”

Section: Anticancer Activitymentioning

confidence: 99%

Helianthus tuberosus

Lim¹

2014

Edible Medicinal and Non Medicinal Plants

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Cytotoxic constituents from the leaves of Jerusalem artichoke (Helianthus tuberosus L.) and their structure–activity relationships

Cited by 27 publications

References 15 publications

Phytochemicals in bioenergy crops

Phytochemicals in bioenergy crops

Topinambur – new possibilities for use in a supplementation diet

Helianthus tuberosus

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