Cytotoxic constituents of Oldenlandia umbellata and isolation of a new symmetrical coumarin dimer

Senthi, Mahibalan; Rao, Poorna Chandra; Khan, Rukaiyya; Basha, Ameer; Siddareddy, Ramakrishna; Masubuti, Hironori; Fujimoto, Yoshinori; Begum, A. Sajeli

doi:10.1007/s00044-015-1500-z

Cited by 23 publications

(14 citation statements)

References 17 publications

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“…The observed cytotoxic effects against MDA-MB-231 cells that were shown by G. meridionalis , G. cordifolia and G. punctata may be connected to asperuloside and its derivatives ( Table 3 ) [ 102 , 103 , 104 ]. Ethanolic extract of Oldenlandia diffusa (Willd.)…”

Section: Resultsmentioning

confidence: 99%

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

et al. 2022

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Species from the genus Globularia L. have been used as healing agents for various ailments, with utilization of Globularia alypum L. being most frequently reported. The aim of this study was to evaluate the antidiabetic, antioxidant, anti-inflammatory, antibacterial and anticancer potential of G. alypum and three related species, G. punctata Lapeyr., G. cordifolia L. and G. meridionalis (Podp.) O.Schwarz, in relation to their phytochemical compositions. Globularin and verbascoside were identified using LC-PDA-ESI-MSn as the major metabolites of G. alypum with known biological activities. G. alypum demonstrated the greatest α-glucosidase inhibitory activity and DPPH radical scavenging activity (IC50 = 17.25 μg/mL), while its anti-inflammatory activity was not significantly different from those of related species. All investigated species showed considerable antibacterial activity against methicillin-resistant Staphylococcus aureus in the broth microdilution method (MIC = 1.42–3.79 mg/mL). G. punctata also showed antibacterial activities against Escherichia coli (MIC = 1.42 mg/mL), Bacillus subtilis (MIC = 1.89 mg/mL), B. cereus (MIC = 2.84 mg/mL) and Enterococcus faecalis (MBC = 5.68 mg/mL). G. punctata, G. cordifolia and G. meridionalis showed greater anticancer potential than G. alypum. Obtained results indicate investigated Globularia species could serve as sources of diverse bioactive molecules, with G. punctata having the greatest antibacterial potential.

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Section: Resultsmentioning

confidence: 99%

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

et al. 2022

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“…The 13 C NMR and HSQC spectra of 1 revealed 11 carbon signals, including one methyl, one methoxyl, one ester carbonyl and eight olefinic carbons. These NMR and MS data suggested that compound 1 was most likely a symmetrical coumarin dimer derivative [ 12 , 13 ], wherein each subunit was substituted by one methoxyl and one methyl, and connected together by one oxygen atom. Comparison of the NMR spectral data of compound 1 with those of the known 7-hydroxy-4-methoxy-5-methylcoumarin [ 11 ] showed great similarity in that they both use deuterated dimethyl sulfoxide as solvent.…”

Section: Resultsmentioning

confidence: 99%

Identification and Antifungal Activity of Compounds from the Mangrove Endophytic Fungus Aspergillus clavatus R7

Xiong

Zheng

et al. 2017

Marine Drugs

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Two new coumarin derivatives, 4,4′-dimethoxy-5,5′-dimethyl-7,7′-oxydicoumarin (1), 7-(γ,γ-dimethylallyloxy)-5-methoxy-4-methylcoumarin (2), a new chromone derivative, (S)-5-hydroxy-2,6-dimethyl-4H-furo[3,4-g]benzopyran-4,8(6H)-dione (5), and a new sterone derivative, 24-hydroxylergosta-4,6,8(14),22-tetraen-3-one (6), along with two known bicoumarins, kotanin (3) and orlandin (4), were isolated from an endophytic fungus Aspergillus clavatus (collection No. R7), isolated from the root of Myoporum bontioides collected from Leizhou Peninsula, China. Their structures were elucidated using 1D- and 2D- NMR spectroscopy, and HRESIMS. The absolute configuration of compound 5 was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Compound 6 significantly inhibited the plant pathogenic fungi Fusarium oxysporum, Colletotrichum musae and Penicillium italicum, compound 5 significantly inhibited Colletotrichum musae, and compounds 1, 3 and 4 greatly inhibited Fusarium oxysporum, showing the antifungal activities higher than those of the positive control, triadimefon.

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“…Oldenlandia umbellata L. (Family Rubiaceae) is a small profusely branched biennial herbaceous plant native to Indian subcontinent. The red coloured dye from the roots of the plant makes the plant both pharmacologically and industrially important (Siva 2007;Siva et al 2009aSiva et al , 2012Mahibalan et al 2016). Though the plant is well known for its medicinal and industrial applications, there were very few reports of the in vitro production of high yielding plants.…”

Section: Introductionmentioning

confidence: 99%

Auxin and nutritional stress coupled somatic embryogenesis in Oldenlandia umbellata L.

Krishnan

Siril

2017

Physiol Mol Biol Plants

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Somatic embryos were induced from internodal segment derived callus of L., in MS medium supplemented with different concentrations of 2,4-Dichlorophenoxy acetic acid (2,4-D). Initially calli were developed from internodes of microshoots inoculated in 2.5 µM NAA supplemented medium. Then calli were transferred to 2,4-D added medium for somatic embryogenesis. Nutritional stress coupled with higher concentration of 2,4-D triggered somatic embryogenesis. Nutritional stress was induced by culturing callus in a fixed amount of medium for a period up to 20 weeks without any external supply of nutrients. Addition of 2.5 µM 2,4-D gave 100% embryogenesis within 16 weeks of incubation. Callus mass bearing somatic embryos were transferred to germination medium facilitated production of in vitro plantlets. MS medium supplemented with 2.5 µM benzyl adenine and 0.5 µM α-naphthalene acetic acid produced 15.33 plants per culture within 4 weeks of culture. Somatic embryo germinated plants were then hardened and transferred to green house.

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Cytotoxic constituents of Oldenlandia umbellata and isolation of a new symmetrical coumarin dimer

Cited by 23 publications

References 17 publications

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

Identification and Antifungal Activity of Compounds from the Mangrove Endophytic Fungus Aspergillus clavatus R7

Auxin and nutritional stress coupled somatic embryogenesis in Oldenlandia umbellata L.

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