2010
DOI: 10.1016/j.phytochem.2010.02.007
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Cytotoxic dihydrobenzophenanthridine alkaloids from the roots of Macleaya microcarpa

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Cited by 58 publications
(42 citation statements)
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“…For instance, compounds 5, 7 and 10 were tested against KB tumour cells in vitro (Stermitz et al 1973); compounds 2, 9 and 10 exhibited cytotoxicity against P-388 or HT-29 cell lines (Chen et al 2005). From the view of structure -activity relationship (Deng & Qin 2010), these in vitro results suggested that for the active compounds in this work, cytotoxic activities were enhanced by methoxylation at C-6. Indeed, compounds 6 and 7 showed stronger cytotoxicity against selected cells than other isolates, it seemed that the substitution at C-6 was more important than other positions in respect to the activity.…”
Section: Resultsmentioning
confidence: 68%
“…For instance, compounds 5, 7 and 10 were tested against KB tumour cells in vitro (Stermitz et al 1973); compounds 2, 9 and 10 exhibited cytotoxicity against P-388 or HT-29 cell lines (Chen et al 2005). From the view of structure -activity relationship (Deng & Qin 2010), these in vitro results suggested that for the active compounds in this work, cytotoxic activities were enhanced by methoxylation at C-6. Indeed, compounds 6 and 7 showed stronger cytotoxicity against selected cells than other isolates, it seemed that the substitution at C-6 was more important than other positions in respect to the activity.…”
Section: Resultsmentioning
confidence: 68%
“…The molecular formula of ambidalmine D (4) 13 C NMR spectroscopic data were very similar to those of 1 (Tables 1 and 2), except for the replacement of the two methoxy groups in compound 1 by a methylenedioxy group at C2 and C3. An HMBC correlation between the 1 0 -H 2 of the acetonyl group and C6 confirmed its location at the C6.…”
Section: Structure Elucidationmentioning
confidence: 73%
“…They are relatively rare alkaloids in the genus Corydalis; however, they exhibit a broad range of biological and pharmacological properties, such as sanguinarine in iminium or alkanolamine form could interact with DNA and showed potential clinical utility in cancer [5]. What's more, they also showed leishmanicidal and trypanocidal [6,7], antimicrobial [8], antimicrotubule [9], anti-HBV [10], analgesic and anti-inflammatory [11,12], cytotoxic [13], mosquito larvicidal [14] and anti-proliferative [15,16] activities, but until now there is no report on the protective effects on myocardial cells.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Five dihydrobenzophenanthridine alkaloids, named as maclekarpines A-E, were isolated from the roots of Macleaya microcarpa, together with 10 known benzophenanthridine/dihydrobenzophenanthridine derivatives and a known amide (Deng and Qin, 2010; Table 5.1 and Figure 5.2). Some of these compounds showed cytotoxicity against five human tumor cell lines.…”
Section: Anticancer Activity: Multiple Mechanismsmentioning
confidence: 99%