Cytotoxic effect against 3T3 fibroblasts cells of saffron floral bio-residues extracts

Serrano-Díaz, Jéssica; Estevan, Carmen; Sogorb, Miguel A.; Carmona, Manuel; Alonso, Gonzalo L.; Vilanova, Eugenio

doi:10.1016/j.foodchem.2013.09.130

Cited by 24 publications

(28 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding anthocyanins, the profile was dominated by delphinidin 3,5-di-O-glucoside (6.28 ± 0.44 mg g −1 dm). This outcome is in accordance with previous studies [40,41], which showed that the predominant flavonol found in aqueous SPW extract was kaempferol 3-O-sophoroside (30.34 mg g −1 dm), followed by kaempferol 3-O-sophoroside 7-O-glucoside (5.6 mg g −1 dm) and quercetin 3-O-sophoroside (4.01 mg g −1 dm). However, important amounts of delphinidin 3,5-di-O-glucoside (23.19 mg g −1 dm) were determined in ethanolic extract, whereas the aqueous extract was relatively rich in petunidin 3,5-diglucoside (3.97 mg g −1 dm).…”

Section: Polyphenolic Compositionsupporting

confidence: 93%

Saffron Processing Wastes as a Bioresource of High-Value Added Compounds: Development of a Green Extraction Process for Polyphenol Recovery Using a Natural Deep Eutectic Solvent

et al. 2019

View full text Add to dashboard Cite

The current investigation was undertaken to examine saffron processing waste (SPW) as a bioresource, which could be valorized to produce extracts rich in antioxidant polyphenols, using a green, natural deep eutectic solvent (DES). Initially, there was an appraisal of the molar ratio of hydrogen bond donor/hydrogen bond acceptor in order to come up with the most efficient DES composed of L-lactic acid/glycine (5:1). The following step was the optimization of the extraction process using response surface methodology. The optimal conditions thus determined were a DES concentration of 55% (w/v), a liquid-to-solid ratio of 60 mL g−1, and a stirring speed of 800 rounds per minute. Under these conditions, the extraction yield in total polyphenols achieved was 132.43 ± 10.63 mg gallic acid equivalents per g of dry mass. The temperature assay performed within a range of 23 to 80 °C, suggested that extracts displayed maximum yield and antioxidant activity at 50–60 °C. Liquid chromatography-mass spectrometry analysis of the SPW extract obtained under optimal conditions showed that the predominant flavonol was kaempferol 3-O-sophoroside and the major anthocyanin delphinidin 3,5-di-O-glucoside. The results indicated that SPW extraction with the DES used is a green and efficient methodology and may afford extracts rich flavonols and anthocyanins, which are considered to be powerful antioxidants.

show abstract

Section: Polyphenolic Compositionsupporting

confidence: 93%

Saffron Processing Wastes as a Bioresource of High-Value Added Compounds: Development of a Green Extraction Process for Polyphenol Recovery Using a Natural Deep Eutectic Solvent

et al. 2019

View full text Add to dashboard Cite

show abstract

“…However, we could not find reports on uses of petals in traditional medicine. Recent reports though have identified pharmacological activity in extracts of C. sativus petals [38,39,40,41,42,43,44]. The goal of our study was to extract and purify antioxidant compounds from saffron flowers, since these are often considered as 16 …”

Section: Discussionmentioning

confidence: 99%

Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol

et al. 2015

View full text Add to dashboard Cite

“…Currently, the petals of saffron flowers are discarded as waste material, though their chemical profile is similar to that of the stigmas [3]. It has been shown that saffron petals are rich in several antioxidant compounds like flavonols and flavanones [4], but contain less crocin [5]. The antioxidants have been considered as the active ingredients responsible for a variety of health-enhancing properties that were traditionally attributed to saffron.…”

Section: Introductionmentioning

confidence: 99%

New Hydrogels Enriched with Antioxidants from Saffron Crocus Can Find Applications in Wound Treatment and/or Beautification

Zeka

Ruparelia

Sansone

et al. 2018

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Saffron extracts have a long history of application as skin protectant, possibly due to their ability to scavenge free radicals. In this work, the performance of a hydrogel enriched with antioxidant compounds isolated from saffron crocus (Crocus sativus L.) petals was tested. These hydrogels could be considered as new drug delivery system. Hydrogels are crosslinked polymer networks that absorb large quantities of water but retain the properties of a solid, thus making ideal dressings for sensitive skin. We tested antioxidant-enriched hydrogels on primary mouse fibroblasts. Hydrogels enriched with kaempferol and crocin extracted from saffron petals showed good biocompatibility with in vitro cultured fibroblasts. These new types of hydrogels may find applications in wound treatment and/or beautification.

show abstract

Cytotoxic effect against 3T3 fibroblasts cells of saffron floral bio-residues extracts

Cited by 24 publications

References 16 publications

Saffron Processing Wastes as a Bioresource of High-Value Added Compounds: Development of a Green Extraction Process for Polyphenol Recovery Using a Natural Deep Eutectic Solvent

Saffron Processing Wastes as a Bioresource of High-Value Added Compounds: Development of a Green Extraction Process for Polyphenol Recovery Using a Natural Deep Eutectic Solvent

Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol

New Hydrogels Enriched with Antioxidants from Saffron Crocus Can Find Applications in Wound Treatment and/or Beautification

Contact Info

Product

Resources

About