Cytotoxic Effect of 5-Fluorouracil-loaded Polymer-coated Magnetite Nanographene Oxide Combined with Radiofrequency

Abstract

Therefore, PCL/CHI-SPION-NGO can deliver 5-Fu more efficiently into the CT26 cells.

Dual-Targeting Temozolomide Loaded in Folate-Conjugated Magnetic Triblock Copolymer Nanoparticles to Improve the Therapeutic Efficiency of Rat Brain Gliomas

“…These results indicated that the synthesized nanoparticles have imaging capability due to the presence of SPIONs and could even be applied in real time monitoring in addition to the drug delivery platform (meaning theranostic nanoparticles). It was confirmed in previous studies that SPIONs produced negative contrast in MR imaging by reducing T2 relaxation time. , …”

“…It was confirmed in previous studies that SPIONs produced negative contrast in MR imaging by reducing T2 relaxation time. 43,44 According to the ICP-OES results, the highest uptake rate of TMZ-loaded nanoparticles with or without FA and with or without MF at different times occurred in the spleen, liver, heart, kidneys, and ultimately the brain (healthy and tumor tissues, Figure 7). Similar results have also been reported for nanoparticles modified with FA and magnetic nanoparticle, respectively, by Li et al and Chertok et al, indicating that folic acid ligands or magnetic field has no significant effect on the uptake of other organs except the brain.…”

An overview and bibliometric analysis on the colorectal cancer therapy by magnetic functionalized nanoparticles for the responsive and targeted drug delivery

“…Khoei et al . reported an investigation on the uptake and cytotoxic effect of polycaprolactone/chitosan/nanographene oxide coated on Fe 3 O 4 MNPs as a carrier for 5-FU, and then studied radiofrequency hyperthermia, using the alternate magnetic field on proliferation capacity of CT26 colon cancer cell [ 99 ]. The dialysis bag method was used to measure the 5-FU drug release from functionalized MNPs, and it resulted in enhanced cellular uptake with elevated MNPs concentrations.…”

Green decoration of graphene oxide Nano sheets with gelatin and gum Arabic for targeted delivery of doxorubicin

“…GO exhibits a p-conjugated structure, where efficient loading of drugs onto GO nano sheets occurs by π-π stacking and van de Waals forces [4] . GO has been used as an excellent nanocarrier for various model drugs, for example ibuprofen and amoxicillin [14] , heparin [15] , 5-fluorouracil [16] , and doxorubicin [17] .…”