Cytotoxic Effect of Caffeic Acid Loaded in Chitosan-Grafted Carbon Nanotubes on MDA-MB-231 Breast Cancer Cell Lines

Rahimi, Hamideh; Mohammadgholi, Azadeh; Koosha, Mojtaba

doi:10.1007/s40995-023-01465-z

Iran J Sci

2023

DOI: 10.1007/s40995-023-01465-z

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Cytotoxic Effect of Caffeic Acid Loaded in Chitosan-Grafted Carbon Nanotubes on MDA-MB-231 Breast Cancer Cell Lines

Hamideh Rahimi

Azadeh Mohammadgholi

Mojtaba Koosha

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2024

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Adjuvant Properties of Caffeic Acid in Cancer Treatment

Cortez,

Villegas,

Burgos

et al. 2024

IJMS

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Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz in 1867 as a breakdown product of caffetannic acid. CA is biosynthesized from the amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including its antioxidant, anti-inflammatory, and anticancer properties. These effects are attributed to its ability to modulate several pathways, such as inhibiting NFkB, STAT3, and ERK1/2, thereby reducing inflammatory responses, and activating the Nrf2/ARE pathway to enhance antioxidant cell defenses. The consumption of CA has been linked to a reduced risk of certain cancers, mitigation of chemotherapy and radiotherapy-induced toxicity, and reversal of resistance to first-line chemotherapeutic agents. This suggests that CA could serve as a useful adjunct in cancer treatment. Studies have shown CA to be generally safe, with few adverse effects (such as back pain and headaches) reported. This review collates the latest information from Google Scholar, PubMed, the Phenol-Explorer database, and ClinicalTrials.gov, incorporating a total of 154 articles, to underscore the potential of CA in cancer prevention and overcoming chemoresistance.

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Adjuvant Properties of Caffeic Acid in Cancer Treatment

Cortez,

Villegas,

Burgos

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Cytotoxic Effect of Caffeic Acid Loaded in Chitosan-Grafted Carbon Nanotubes on MDA-MB-231 Breast Cancer Cell Lines

Cited by 1 publication

References 20 publications

Adjuvant Properties of Caffeic Acid in Cancer Treatment

Adjuvant Properties of Caffeic Acid in Cancer Treatment

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