Cytotoxic Effect of Emodin on Growth of SKBR3 Breast Cancer Cells

Kalkhoran, Maryam Rezapour; Kazerouni, Faranak; Omrani, Mir Davood; Rahimipour, Ali; Shanaki, Mehrnoosh; Dehghan-Nayeri, Nasrin; Ahmadi, Farrokhlagha; Younesian, Ommolbanin; Cheshmi, Fatemeh

doi:10.5812/ijcm.8094

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…In another study, it was found that emodin also caused apoptosis in SKBR3 cells via caspases. Caspase -3, -8, and -9 mRNA levels increased in SKBR3 cells after administration of emodin at 25 and 50 µM concentration for 48 h. A significant increase in Bax and reduction in Bcl 2 were also observed [89].…”

Section: Breast Cancermentioning

confidence: 84%

Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin

Akkol

Tatlı

Karatoprak

et al. 2021

Cancers

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Many anticancer active compounds are known to have the capacity to destroy pathologically proliferating cancer cells in the body, as well as to destroy rapidly proliferating normal cells. Despite remarkable advances in cancer research over the past few decades, the inclusion of natural compounds in researches as potential drug candidates is becoming increasingly important. However, the perception that the natural is reliable is an issue that needs to be clarified. Among the various chemical classes of natural products, anthraquinones have many biological activities and have also been proven to exhibit a unique anticancer activity. Emodin, an anthraquinone derivative, is a natural compound found in the roots and rhizomes of many plants. The anticancer property of emodin, a broad-spectrum inhibitory agent of cancer cells, has been detailed in many biological pathways. In cancer cells, these molecular mechanisms consist of suppressing cell growth and proliferation through the attenuation of oncogenic growth signaling, such as protein kinase B (AKT), mitogen-activated protein kinase (MAPK), HER-2 tyrosine kinase, Wnt/-catenin, and phosphatidylinositol 3-kinase (PI3K). However, it is known that emodin, which shows toxicity to cancer cells, may cause kidney toxicity, hepatotoxicity, and reproductive toxicity especially at high doses and long-term use. At the same time, studies of emodin, which has poor oral bioavailability, to transform this disadvantage into an advantage with nano-carrier systems reveal that natural compounds are not always directly usable compounds. Consequently, this review aimed to shed light on the anti-proliferative and anti-carcinogenic properties of emodin, as well as its potential toxicities and the advantages of drug delivery systems on bioavailability.

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Section: Breast Cancermentioning

confidence: 84%

Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin

Akkol

Tatlı

Karatoprak

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

“…Using MCF-7 and MDA-MB-453 (human cells), Huang et al [40] test the anticancer impact of emodin to decreased endoplasmic reticulum (ER) protein levels and suppressed ER transcriptional activation, which in turn restricted cell growth 20 µmol/L IC 50 for toxicity against MCF-7 cells [40]. The proliferation of SKBR3 (human cells) was checked by Kalkhoran et al [41] and work with an IC 50 value of 25 µmol/L raised the expression of the mRNAs for caspase-3, caspase-8, caspase-9, and Bax, decreased the expression of Bcl-2, and induced apoptosis [41].…”

Section: Anticancer Activity Of Emodin For the Management Of Various ...mentioning

confidence: 99%

Anticancer action of naturally occurring emodin for the controlling of cervical cancer

Lande,

Adhao,

Ambhore

et al. 2023

Exploration of Targeted Anti-Tumor Therapy

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One of the major causes of death on the globe is cancer. The fourth most frequent malignancy in women worldwide is cervical cancer. Several cancer patients are remaining incurable due to the emergence of medication resistance, despite notable advances in cancer research over the previous few decades. The importance of natural sources as possible therapeutic candidates may be significant. Anthraquinones are one of the many chemical families of natural products, and they stand out for their wide range of structural variations, notable biological activity, and low toxicity. A natural substance called emodin, an anthraquinone derivative, is present in the roots and rhizomes of several plants. This substance has demonstrated antineoplastic, anti-inflammatory, antiangiogenic, and antiproliferative properties. It is also capable of preventing cancer spread and can reverse cancer cells’ multidrug resistance. Emodin, a broad-spectrum inhibitor of cancer cells, have anticancer properties in many different types of biological pathways. These molecular mechanisms in cancer cells include the suppression of cell growth and proliferation, deterioration of the cell cycle arrest, the start of apoptosis, antimetastasis, and antiangiogenic impact. Therefore, the aim of the present review summarised the antiproliferative and anticarcinogenic qualities of cervical cancer of emodin.

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“…Scientific studies have also discovered lots of beneficial properties of R. palmatum . As reported, R. palmatum contains a variety of bioactive components such as aloe emodin, chrysophanol, rhein, emodin, and physcion [5] , which have been shown to exhibit significant anti-inflammatory [6–8] , anti-viral [5,9] and anti-tumor activities [10–12] .…”

Section: Introductionmentioning

confidence: 99%

Characterization of Rheum palmatum mitochondrial genome and comparative analysis among Caryophyllales species

Gao,

Hao,

et al. 2023

Acupuncture and Herbal Medicine

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Objective: This work aimed to report the first complete mitochondrial genome (mitogenome) of Rheum palmatum, summarize the features of Caryophyllales mitogenomes and to reveal the potential of utilizing the mitogenomes of R. palmatum and other Caryophyllales species for inferring phylogenetic relationships and species identification. Methods: Both Illumina short reads and PacBio HiFi reads were utilized to obtain a complete mitogenome of R. palmatum. A variety of bioinformatics tools were employed to characterize the R. palmatum mitogenome, compare the reported mitogenomes in Caryophyllales and conduct phylogenetic analysis. Results: The mitogenome of R. palmatum was assembled into a single master circle of 302,993 bp, encoding 35 known protein-coding genes, 18 tRNA genes and 3 rRNA genes. A total of 249 long repeats and 49 SSRs were identified in this mitogenome. The sizes of mitogenomes in Caryophyllales varied from 253 kb to 11.3 Mb. Among them, twenty-three mitogenomes were circular molecules, one was linear, and one consisted of relaxed circles, linear molecules, and supercoiled DNA. Out of the total mitogenomes, eleven were single-chromosome structure, while the remaining fourteen were multi-chromosomal organizations. The phylogenetic analysis is consistent with both the Engler system (1964) and the Angiosperm Phylogeny Group III (APG III) system. Conclusions: We obtained the first mitogenome of R. palmatum, which consists of a master circle. Mitogenomes in Caryophyllales have variable genome sizes and structures even within the same species. Circular molecules are still the dominant pattern in Caryophyllales. Single-chromosome mitogenomes account for nearly a half of all the mitogenomes in Caryophyllales, in contrast to previous studies. It is feasible to utilize mitochondrial genomes for inferring phylogenetic relationships and conducting species identification.

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Cytotoxic Effect of Emodin on Growth of SKBR3 Breast Cancer Cells

Cited by 4 publications

References 21 publications

Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin

Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin

Anticancer action of naturally occurring emodin for the controlling of cervical cancer

Characterization of Rheum palmatum mitochondrial genome and comparative analysis among Caryophyllales species

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