Cytotoxic effect of mistletoe (<i>Viscum album</i> L.) extract on Jurkat cells and its interaction with doxorubicin

Sabová, Lucia; Pilátová, Martina; Szilagyi, Katarina; Sabo, Rastislav; Mojžiš, Ján

doi:10.1002/ptr.2947

Cited by 26 publications

(12 citation statements)

References 21 publications

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“…A previous study indicated that lectins selectively bind to malignant cells because they only bind to specific carbohydrates by recognizing domains present in cell membranes that are differentially expressed in non-tumor cells (Sharon, 2007; Sabova et al, 2010; Koh et al, 2011; Nolte et al, 2012). The internalization of lectin improves its intracellular availability and activity (Lichtenstein and Rabinovich, 2013).…”

Section: Resultsmentioning

confidence: 99%

Eutirucallin: A Lectin with Antitumor and Antimicrobial Properties

Palharini

Richter

Silva

et al. 2017

Front. Cell. Infect. Microbiol.

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Eutirucallin is a lectin isolated from the latex of Euphorbia tirucalli, a plant known for its medical properties. The present study explores various characteristics of Eutirucallin including stability, cytotoxicity against tumor cells, antimicrobial and antiparasitic activities. Eutirucallin was stable from 2 to 40 days at 4°C, maintained hemagglutinating activity within a restricted range, and showed optimal activity at pH 7.0–8.0. Eutirucallin presented antiproliferative activity for HeLa, PC3, MDA-MB-231, and MCF-7 tumor cells but was not cytotoxic for non-tumorigenic cells such as macrophages and fibroblasts. Eutirucallin inhibited the Ehrlich ascites carcinoma in vivo and it was also observed that Eutirucallin inhibited 62.5% of Escherichia coli growth. Also, Eutirucallin showed to be effective when tested directly against Toxoplasma gondii infection in vitro. Therefore, this study sheds perspectives for pharmacological applications of Eutirucallin.

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Section: Resultsmentioning

confidence: 99%

Eutirucallin: A Lectin with Antitumor and Antimicrobial Properties

Palharini

Richter

Silva

et al. 2017

Front. Cell. Infect. Microbiol.

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“…The proteasome inhibitor bortezomib enhanced the antiproliferative property of mistletoe lectin on human G631 melanoma cells [136]. Also, combination of doxorubicin and mistletoe extracts containing lectin caused cytotoxicity and induced DNA fragmentation to human leukemia Jurkat cells [137]. The use of mistletoe extracts in clinical trials has shown promising results.…”

Section: Plant Lectinsmentioning

confidence: 98%

The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells

Mejía

Dia

2010

Cancer Metastasis Rev

153

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The process of carcinogenesis is complex and not easy to eliminate. It includes the initial occurrence of genetic alterations which can lead to the inactivation of tumor-suppressor genes and further accumulation of genetic alterations during tumor progression. Looking for food and food components with biological properties, collectively called nutraceuticals, that can hinder such alterations and prevent the inactivation of tumor-suppressor genes is a very promising area for cancer prevention. Proteins and peptides are one group of nutraceuticals that show potential results in preventing the different stages of cancer including initiation, promotion, and progression. In this review, we summarized current knowledge on the use of nutraceutical proteins and peptides in cancer prevention and treatment. We focused on the role of plant protease inhibitors, lactoferrin and lactoferricin, shark cartilage, plant lectins, and lunasin in the apoptosis, angiogenesis, and metastasis of cancer cells. Also included are studies on bioavailability and clinical trials conducted on these promising proteins and peptides.

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“…Iscador, the aqueous preparation of V. album L. is regarded a potent CAM. Sabova et al (2010) investigated the cytotoxic and apoptosis-inducing effects of aqueous mistletoe extract alone or in combination with doxorubicin on Jurkat cells. Dose-dependent DNA fragmentation was induced in Jurkat cells individually as well as synergistically.…”

Section: Synergistic Effectsmentioning

confidence: 99%

Emerging roles of mistletoes in malignancy management

Patel

Panda²

2013

3 Biotech

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Mistletoes are a group of obligate plant semi-parasites in the order Santalales. These clumps of plants growing on a wide range of host plants have been traditionally regarded as medicinal repositories. However, current scientific discoveries have validated their health potentials like never before. Their extracts containing alkaloids, viscotoxins, lectins, and polysaccharides have been evidenced to possess a myriad biological potentials including cancer inhibition. Mistletoes have emerged as promising alternative therapy against colon, oral, lung, and pancreas cancers. The plant extracts bolster immunity, delay tumour initiation and progression, kill malignant tumours, stabilize DNA, alleviate side effects of chemotherapeutics, improve the lifespan, and coping ability of cancer patients and survivors. A range of proprietary formulations viz. Iscador, Eurixor, Helixor, Lektinol, Isorel, Iscucin, Abnoba-viscum and recombinant lectin ML-1 are already being commercialized. This review presents an informative account on the recent developments in mistletoe-mediated cancer management. The underlying mechanisms, possibilities and limitations in cancer therapeutic development are outlined for kindling both researcher and public interest.

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Cytotoxic effect of mistletoe (Viscum album L.) extract on Jurkat cells and its interaction with doxorubicin

Cited by 26 publications

References 21 publications

Eutirucallin: A Lectin with Antitumor and Antimicrobial Properties

Eutirucallin: A Lectin with Antitumor and Antimicrobial Properties

The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells

Emerging roles of mistletoes in malignancy management

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