Cytotoxic effect of the immunotoxin constructed of the ribosome-inactivating protein curcin and the monoclonal antibody against Her2 receptor on tumor cells

Jaramillo-Quintero, Lidia Patricia; de, Arturo Contis-Montes; Rojas, Andrés Romero; Rojas-Hernández, Saúl; Campos-Rodrı́guez, Rafael; Martínez-Ayala, Alma Leticia

doi:10.1080/09168451.2015.1006572

Cited by 9 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, there are different reports showing the toxic activity of curcin (LIN et al, 2003;QIN et al, 2010;HE et al, 2011;PRAHAN et al, 2012;ZAHO et al, 2012;JARAMILLO-QUINTERO et al, 2015). Curcin is a toxalbumin protein extracted from J. curcas seeds that present in vitro effect inhibiting protein synthesis, which is called ribosome-inactivating protein (RIP).…”

Section: Discussionmentioning

confidence: 99%

Toxicity of Jatropha curcas L. latex in Allium cepa test

Ciappina¹,

Ferreira²,

Pereira³

et al. 2017

Biosci. J.

View full text Add to dashboard Cite

ABSTRACT:The latex obtained from Jatropha curcas (physic nut) is used in traditional medicine to treat a variety of disturbs, including burns, hemorrhoids, ringworm and ulcers. Phytochemical analyses have shown that J. curcas latex contains natural compounds with therapeutic potential. In this study, the toxicity, cytotoxicity and genotoxicity effects of J. curcas latex on the root cells of Allium cepa were examined. Onion seeds and bulbs were exposed to seven different concentrations of latex and then the roots were submitted to macro and microscopic analyses. Water and sodium azide were used as negative and positive controls, respectively. The analysis of root growth showed that J. curcas crude latex or 50% diluted is highly toxic. Cytogenetic results showed that the mitotic index of the onion roots submitted to latex treatment decreased significantly compared to the negative control, which suggests that the latex is cytotoxic. High incidence of chromosome aberrations in the cells treated with J. curcas latex was observed too, indicating that the latex also presents genotoxic effect. The analyses presented in this report suggest the toxic, cytotoxic and genotoxic effects of J. curcas latex. Then, the indiscriminate use of J. curcas latex in folk medicine could bring risk to human health.

show abstract

Section: Discussionmentioning

confidence: 99%

Toxicity of Jatropha curcas L. latex in Allium cepa test

Ciappina¹,

Ferreira²,

Pereira³

et al. 2017

Biosci. J.

View full text Add to dashboard Cite

show abstract

“…Curcine, the protein present in J. curcas seeds, for example, has expressive antifungal activity, and may completely inhibit the formation of spores of Pyrucularia oryzae, a fungus that damages the rice crop. However, this substance may inhibit protein synthesis processes in animals (Jaramillo-Quintero et al, 2015;Wei et al, 2004). 2S albumin is another example of a molecule present in J. curcas with diverse effects.…”

Section: Main Metabolites Of J Curcas For Pest and Disease Controlmentioning

confidence: 99%

Biocide Potential of Jatropha curcas L. Extracts

Muniz¹,

Zaidan²,

Dias³

et al. 2020

JBLS

View full text Add to dashboard Cite

Jatropha curcas L., a multipurpose oilseed plant, is very important for biodiesel production; it also has a wide range of bioactive compounds with medicinal properties and biocidal activity for control of crop pests and diseases. This review presents the state-of-the-art of the biocidal activity of J. curcas extracts. Chemical constituents such as phorbol esters are responsible for high bioactivity of J. curcas, due to their toxicity to humans and animals and to their high fungicidal and insecticidal activity. The fungicidal activity of these constituents may be due to destroy endoplasmatic reticulum and hyphae cell walls. The activity of these compounds on insect pest metabolism is well known, leading to an antifeedant effect, repellency, mating inhibition, oviposition inhibition or suppression and/or induction of infertile egg production, and inhibition of larva, nymph, and pupa development. Several studies have shown that although all organs of J. curcas plant are toxic, the degree of toxicity varies in accordance with the extract formulation, the nature of the active substance, the administration rate and procedure, and the individual sensitivity of pests and diseases. Thus, J. curcas stands out as a promising species for bioenergy purposes, as well as for control of pests and diseases that affect agriculture production.

show abstract