Cytotoxic Effect on Cancerous Cell Lines by Biologically Synthesized Silver Nanoparticles

Balaji, K; Gothandam, Kodiveri Muthukaliannan

doi:10.1590/1678-4324-2016150529

Cited by 36 publications

(24 citation statements)

References 13 publications

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“…The peak at around 1630 cm −1 was representative of crystalline β‐sheet structures, which was in accordance with previous findings on native sericin structure . Amide I representing absorption bands in the region 1630 and 1660 cm −1 were suggestive of additional amorphous random coil structures . For rice starch, all characteristic bands mentioned by Kizil et al were observed .…”

Section: Resultssupporting

confidence: 90%

Development of Novel 2D Composites of Silk Sericin and Rice Starch and Application as Bio‐Compatible Scaffold for Cell Culturing

Dutta

Devi

2018

Starch Stärke

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Sericin and starch are waste materials of the silk and rice milling industries, respectively. Owing to their suitable physicochemical, mechanical and functional properties, the two materials are thermo‐mechanically conjugated and cast as films. Sericin forms a microfibrillar network structure which binds with gelatinized starch. Addition of crosslinkers, namely glycerol and polyethylene glycol results in smoother textured films, higher crystallinity, and thermal resistance as studied using XRD, FTIR, DSC, and TGA. Native crystalline patterns of both starch and sericin are lost during composite formation. Newer crystalline lamellae formation with enhanced crystallinity than the native materials is evident from XRD and DSC. Comparative analysis indicated polyethylene glycol to be a better cross linker than glycerol for the composite formation. Biocompatibility studies using L929 mice fibroblast cell lines demonstrated that the films supported normal growth and proliferation of cells without any toxic effect. This is well supported by fluorescence imaging and MTT assays. Enzymatic biodegradability using protease enzymes implied negligible weight loss of the films, strengthening their prospect to be manifested in cell culturing applications.

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Section: Resultssupporting

confidence: 90%

Development of Novel 2D Composites of Silk Sericin and Rice Starch and Application as Bio‐Compatible Scaffold for Cell Culturing

Dutta

Devi

2018

Starch Stärke

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show abstract

“…And svLAAO induced proapoptotic genes up regulation and down regulation of anti apoptotic genes in a significant way compared with nontreated cells in addition it induced different cellular arrest at G0/G1 phase. In the mean times evaluation of anticancer activity of Ag NPs and its antimicrobial activity , data recorded was in agreement with (Kulandaivelu et al, 2016) demonstrated thatthe cytotoxic effects of the silver nanoparticles could significantly inhibited MCF7 cancer cell line proliferation in a time and concentration-dependent manner by MTT assay. This result is much closed to our result.…”

Section: Resultssupporting

confidence: 85%

Comparative Evaluation Of Anticancer Potential Of Moringaoleifera, Ganodermalucidumand Silver Nanoparticles Against Breast And Liver Cancer Cell Lines And Related Pro And Anti Apoptotic Genes Profile

Hussein¹

2017

ijsrm

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and The holding company for the production of Vaccines , Sera and Drugs (VACSERA). AbstractThe present work aimed to evaluate the anticancer potentials concerning the cytotoxicity and antiproliferative activity of L-amino acid Oxidase (LAAO) ,MoringaOleifera(MO) Methanol (MLM) and water extracts (MLW), Ganodermalucidum(GL), extracts as a natural products and Silver nanoparticles (AgNP) as well. Cytotoxic effect of test extracts on both breast (MCF-7) and liver(HEPG-2) cancer cell lines varied according to test materials and could be arranged in the order of LAAO > MLM>AgNP> GL>MLW. Also, (MCF7) cell line was more sensitive to test materials compared with (HEPG2) cell line. Regarding the genotoxicity it was found that Bcl2 and survivineand caspase -3 as antiapoptotic genes were significantly down regulated and P53 as proapoptotic genes was significantly up regulated in both cell lines

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“…At 100μg/ mL concentration, the silver nano-particles exhibited significant cytotoxic effects and the apoptotic features were confirmed through caspase-3 activation and DNA fragmentation assays [6]. Silver AgNPs were produced by reduction of Silver Nitrate by using aqueous of fresh aerial parts of Alternanthera Sessilie.…”

Section: Qaysar Mohi Ud Din Biomed J Sci and Tech Res Volume 1-issue 4mentioning

confidence: 92%

“…In most of the cases reducing agents or other constituents present in the cells acts as stabilizing and capping agents, so there is no need of adding capping and stabilizing agents from outside [4]. The Ag+ ions are primary requirement for the synthesis of AgNPs which can be obtained from various water soluble salts of silver [5].…”

Section: Green Synthesis Of Npmentioning

confidence: 99%

Anti-Metastatic Properties of Bio Synthesized Ag NPs on Osteosarcoma (MG-63) Cancer Cell Lines

Din¹

2017

BJSTR

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Cytotoxic Effect on Cancerous Cell Lines by Biologically Synthesized Silver Nanoparticles

Abstract: ABSTRACT

Cited by 36 publications

References 13 publications

Development of Novel 2D Composites of Silk Sericin and Rice Starch and Application as Bio‐Compatible Scaffold for Cell Culturing

Development of Novel 2D Composites of Silk Sericin and Rice Starch and Application as Bio‐Compatible Scaffold for Cell Culturing

Comparative Evaluation Of Anticancer Potential Of Moringaoleifera, Ganodermalucidumand Silver Nanoparticles Against Breast And Liver Cancer Cell Lines And Related Pro And Anti Apoptotic Genes Profile

Anti-Metastatic Properties of Bio Synthesized Ag NPs on Osteosarcoma (MG-63) Cancer Cell Lines

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