Cytotoxic Effect on Osteosarcoma MG-63 Cells by Degradation of Magnesium

Mei, Li; Ren, Ling; Li, Lihua; He, Peng; Lan, Guobo; Zhang, Yu; Yang, Ke

doi:10.1016/j.jmst.2014.04.010

Cited by 58 publications

(36 citation statements)

References 22 publications

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“…8 Therefore, the activity of LDH in the culture medium could reflect the cytotoxicity of materials 35 and LDH test has been widely used in biocompatibility evaluation for magnesium-based biomateri-als. [36][37][38][39][40] In this study, at low Mg 21 concentrations, significantly higher LDH cytotoxicity than that of control was also observed. It was probably because at low Mg 21 concentrations, SMC proliferation rate was enhanced and there were more cells in the low Mg 21 concentration-treated group, leading to an increase in spontaneous LDH release.…”

Section: Discussionsupporting

confidence: 61%

Biphasic responses of human vascular smooth muscle cells to magnesium ion

Zhao

Zhu

2015

J Biomedical Materials Res

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Magnesium-based alloys are promising in biodegradable cardiovascular stent applications. The degradation products of magnesium stents may have significant impacts on the surrounding vascular cells. However, knowledge on the interactions between magnesium ion and vascular cells at the molecular and cellular levels is still largely missing. Vascular smooth muscle cell (SMC) plays an important role in the pathogenesis of restenosis and wound healing after stent implantation. This study evaluated the short-term effects of extracellular magnesium ion (Mg2+) on the cellular behaviors of SMCs. Cellular responses to Mg2+ were biphasic and in a concentration-dependent manner. Low concentrations (10 mM) of Mg2+ increased cell viability, cell proliferation rate, cell adhesion, cell spreading, cell migration rate, and actin expression. In contrast, higher concentrations (40–60 mM) of Mg2+ had deleterious effects on cells. Gene expression analysis revealed that Mg2+ altered the expressions of genes mostly related to cell adhesion, cell injury, angiogenesis, inflammation, coagulation, and cell growth. Finding from this study provides some valuable information on SMC responses toward magnesium ions at the cellular and molecular levels, and guidance for future controlled release of magnesium from the stent material.

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Section: Discussionsupporting

confidence: 61%

Biphasic responses of human vascular smooth muscle cells to magnesium ion

Zhao

Zhu

2015

J Biomedical Materials Res

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“…A wide range of coatings on Mg and Mg alloys have been developed to increase the corrosion resistance, such as conversion coatings (micro arc oxidation (MAO) surface [9][10][11][12] , plasma ion implantation surface [13] , chemical conversion surface [14][15][16][17][18][19] , hydrothermal conversion technique [20] etc. ), deposited coatings (calcium phosphate coating [21][22][23] , TiO 2 coating [24,25] , polymer coating [26,27] etc.)…”

Section: Introductionmentioning

confidence: 99%

Multifunctional MgF2/Polydopamine Coating on Mg Alloy for Vascular Stent Application

Liu

Zhen

Jing

et al. 2015

Journal of Materials Science & Technology

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“…MgOH 2 generated by this reaction will cause the surrounding environment to be strong alkaline, which is also harmful to the adjacent cells and tissues. 106 There are lots of ways used to solve this problem, such as surface modifications including anodic oxidation, alkali heat treatment. After subjected to those surface modification methods, Mg metal releases H 2 in a controlled manner because the surface is covered by a compact passivation coating which will inhibit the corrosion of the inner Mg metal.…”

Section: From Biodegradable Bone Repair Materials To Anti-tumor Metalmentioning

confidence: 99%