Cytotoxic Effects of Castalin Nanoparticles Against Osteosarcoma

Zhang, Shouqiang; Ren, Hui; Sun, Han; Cao, Songhua

doi:10.1007/s12010-022-03846-3

Cited by 2 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Once it degrades, the resulting monomers, lactic acid and glycolic acid, enter the body’s natural metabolic pathways, eventually being converted to water and carbon dioxide and excreted. This metabolic process ensures that there is no long-term accumulation of foreign substances in the body [ 146 , 147 ].…”

Section: Resultsmentioning

confidence: 99%

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Luo,

Sun,

Tan

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Osteosarcoma, a predominant malignant bone tumor, poses significant challenges due to its high metastatic and recurrent nature. Although various therapeutic strategies are currently in use, they often inadequately target osteosarcoma metastasis. This review focuses on the potential of nanoscale drug delivery systems to bridge this clinical gap. It begins with an overview of the molecular mechanisms underlying metastatic osteosarcoma, highlighting the limitations of existing treatments. The review then transitions to an in-depth examination of nanoscale drug delivery technologies, emphasizing their potential to enhance drug bioavailability and reduce systemic toxicity. Central to this review is a discussion of recent advancements in utilizing nanotechnology for the potential intervention of metastatic osteosarcoma, with a critical analysis of several preclinical studies. This review aims to provide insights into the potential applications of nanotechnology in metastatic osteosarcoma therapy, setting the stage for future clinical breakthroughs and innovative cancer treatments.

show abstract

Section: Resultsmentioning

confidence: 99%

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Luo,

Sun,

Tan

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…These results are critical in demonstrating the ability of gene delivery using PLGA-functionalized CNTs for cell fate regulation ( Cheng et al, 2013 ). The PLGA nanoparticles loaded with other anti-cancer agents, such as sclareol ( Cosco et al, 2019 ), castalin ( Zhang et al, 2022 ), and simvastatin ( Venkatesan et al, 2019 ; Jin et al, 2021a ), also present potent anti-cancer activity, indicating that PLGA nanoparticle delivery systems have promising potential for treating bone cancers.…”

Section: Plga Targeted Nano-drug Delivery Systemsmentioning

confidence: 99%

PLGA-based drug delivery systems in treating bone tumors

Qiu

Liu

2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Bone tumor has become a common disease that endangers human health. Surgical resection of bone tumors not only causes biomechanical defects of bone but also destroys the continuity and integrity of bone and cannot completely remove the local tumor cells. The remaining tumor cells in the lesion bring a hidden danger of local recurrence. To improve the chemotherapeutic effect and effectively clear tumor cells, traditional systemic chemotherapy often requires higher doses, and high doses of chemotherapeutic drugs inevitably cause a series of systemic toxic side effects, often intolerable to patients. PLGA-based drug delivery systems, such as nano delivery systems and scaffold-based local delivery systems, can help eliminate tumors and promote bone regeneration and therefore have more significant potential for application in bone tumor treatment. In this review, we summarize the research progress of PLGA nano drug delivery systems and PLGA scaffold-based local delivery systems in bone tumor treatment applications, expecting to provide a theoretical basis for developing novel bone tumor treatment strategies.

show abstract

Cytotoxic Effects of Castalin Nanoparticles Against Osteosarcoma

Cited by 2 publications

References 15 publications

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

PLGA-based drug delivery systems in treating bone tumors

Contact Info

Product

Resources

About