Cytotoxic effects of hydroalcoholic extracts of Cucurbita pepo and Solanum nigrum compared with hydroalcoholic extract of Taxus baccata and cisplatin on normal and cancer cell lines

Shokrzadeh, Mohammad; Azadbakht, Mehri; Ahangar, Nematollah; Naderi, H; Saravi, SS Saeedi

doi:10.1055/s-0029-1234993

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“…Also, defensive disorders and effusion insufficiency to escape toxic substances from cells can lead to lower necessity to amounts of cytotoxic compounds to inhibit the growth of cancer cells in comparison with normal cells. [68]…”

Section: Discussionmentioning

confidence: 99%

Comparison of the cytotoxic effects ofJuniperus sabinaandZataria multifloraextracts withTaxus baccataextract and Cisplatin on normal and cancer cell lines

et al. 2010

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Isolation and identification of some potent anti-tumor compounds from medicinal plants has motivated researchers to screen different parts of plant species for the determination of anti-tumor effects. In this study, cytotoxic effects and IC50 of specific concentrations of hydro-alcoholic extracts of fruits of Juniperus sabina and leaves of Zataria multiflora were compared with hydro-alcoholic extract of bark of Taxus baccata and Cisplatin, well-known anticancer compounds, on normal (CHO and rat fibroblast) and cancer (HepG2 and SKOV3) cell lines. The hydro-alcoholic extracts of the plants were prepared by percolation. The cytotoxic effects and IC50 of the extracts on the cell lines were studied followed by colonogenic assay after 72 h incubation. The results showed that the extract of Juniperus sabina possesses lower IC50 in comparison with Zataria multiflora extract on all 4 normal and cancer cell lines (P<0.05); but, IC50 of the Juniperus sabina extract was significantly higher than the Taxus baccata extract and Cisplatin on all 4 normal and cancer cell lines (P<0.05). As a result, it is concluded that the extract of J. sabina has almost similar cytotoxicity with the extract of Taxus baccata on cancer cells.

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Section: Discussionmentioning

confidence: 99%