Cytotoxic effects of<i>Cuscuta</i>extract on human cancer cell lines

Ghazanfari, Tooba; Naseri, Mohsen; Shams, Jalaleddin; Rahmati, Batool

doi:10.1080/09540105.2011.648608

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…Thus, the results demonstrated that the inhibition of HepG2 cell proliferation induced by PC was stronger than that induced by EA. This was similar to another study, Raji lymphoma cell line was inhibited by Cuscuta extracts (Aribi, Zerizer, Kabouche, Screpanti, & Palermo, 2016;Ghazanfari, Naseri, Shams, & Rahmati, 2013), it suggested that many natural plant extracts could inhibit cancer cells proliferating without affecting normal cells.…”

Section: Effects Of Pc and Ea On Antiproliferation Of Hepg2 Cellssupporting

confidence: 89%

Punicalagin and ellagic acid from pomegranate peel induce apoptosis and inhibits proliferation in human HepG2 hepatoma cells through targeting mitochondria

Wang

Hou

et al. 2019

Food and Agricultural Immunology

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Pomegranate peel polyphenols (PPPs) extracts presented antiproliferation and apoptosis-inducing effects in human HepG2 hepatoma cells in our previous studies. This study aimed to investigate the differential anticancer effects of main PPPs components punicalagin (PC) and ellagic acid (EA) on HepG2 cells and their possible action mechanisms. Cell proliferation, morphology, cell cycle and apoptosis were investigated, and the results revealed that PC and EA mediated the cell-cycle arrest at the S-phase and G0/G1-phase and dose-dependently led to apoptosis in HepG2 cells. In addition, apoptosis-related protein activities and the reactive oxygen species levels showed that the activation of apoptosis-related proteins and the elevation of intracellular H 2 O 2 production were aroused. It revealed that both PC and EA could inhibit cell growth and led to apoptosis in HepG2 cells, and PC was more effective than EA. Furthermore, one of the important apoptosis-inducing mechanisms is the participation of them in the mitochondrial apoptosis pathway.

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Section: Effects Of Pc and Ea On Antiproliferation Of Hepg2 Cellssupporting

confidence: 89%

Punicalagin and ellagic acid from pomegranate peel induce apoptosis and inhibits proliferation in human HepG2 hepatoma cells through targeting mitochondria

Wang

Hou

et al. 2019

Food and Agricultural Immunology

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“…Necrotic cell death comprises a continuum of effects, culminating in nuclear pyknosis, karyorrhexis, and karyolysis (Loannou & Chen, 1996). mg/mL, 2.56 mg/mL and 2.06 mg/mL respectively (Ghazanfari et al, 2013). Methanol fraction from Rubus idaeus also showed in vitro cytotoxic activity on two human leukaemia cell lines, J45 and HL60.…”

Section: Discussionmentioning

confidence: 89%

Toxicity Effects of Chinese Herbal ‘Five-seeds’ Formulation on Human Kidney HEK-293 and Chang Liver Cells

Wong¹,

Teo²,

Er³

et al. 2021

ASMScJ

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‘Five-seeds’ formulation (Lycium barbarum, Cuscuta chinensis Lam, Rubus idaeus, Schisandra chinensis, Plantago asiatica) have been used by Chinese medicine practitioner for the treatment of male infertility for a long time. The present study aims to investigate the potential toxicity effects of the individual herb used in ‘five-seeds’ formulation and as a concoction on human HEK293 and Chang liver cells, using cell viability MTT assay and SubG1 flow cytometry analysis. Percentage of cell viability from samples (1, 25, 50, 75, 100 mg/mL) decreased as the concentration increased. Half maximal inhibitory concentration (IC50) values indicated that Cuscuta chinensis, Rubus idaeus and Schisandra chinensis are among the most toxic herb samples on HEK293 cells, with the IC50 values less than 22 mg/mL. On the other hand, Rubus idaeus (IC50 value 20.1 mg/mL) and Schisandra chinensis (IC50 value 17.8 mg/mL) were found to have the highest toxicity effect on Chang liver cells. Plantago asiatica and Lycium barbarum (IC50 more than 67 mg/mL) are the least toxic herbs tested on both human HEK293 kidney and Chang liver cells. ‘Five-seeds’ herbal formulation had IC50 values of 33 mg/mL and 38.5 mg/mL on HEK293 and Change liver cells respectively, suggesting that ‘five seeds’ formulation has modulated the toxicity effect of the mixed herbs used in this formula. Apoptotic cells in SubG1 phase were also found to be significantly low for HEK293 (13.08%) and Chang liver cells (10.17%) with the treatment of 25 mg/mL of ‘five seeds’ formulation. Toxicity effect of five-seeds’ herbal formulation has seemingly been modulated when all the five herbs mixed as a concoction, and potentially non-toxic as a concoction to HEK293 kidney and Chang liver cells. However, more investigations should be done to draw a solid conclusion.

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“…Previous studies have shown that some aftimun species have anti-cancer properties [57]. Studies evaluating the effects of aftimun (Cuscuta kotschyana and Cuscuta chinensis) in different cell lines including HL60, MCF7, T47D, CCRF-CEM and Jurkat (JM), show the cytotoxic properties of this plant species, although the evidence available is scarce [36,60].…”

Section: Phytochemical and Pharmacological Properties Of Aftimunmentioning

confidence: 99%

A Review on the Botanical, Phytochemical and Pharmacological Characteristics of Cuscuta Spp.

K¹,

Omidi²,

Dehaghi³

2022

Parasitic Plants

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Parasitic life is an example of interaction between two species. The result is positive for one and negative for another. Parasitic plants are more evolved than other species in the same family. Cuscuta spp. or dodder is one of the medicinal herbs that belong to the Convolvulaceae plant family. They are annual parasitic plants that reproduce by seed. These parasitic plants do not have any roots, leaves or chlorophyll to produce their own food. Dodders live by attaching to a host plant with small appendages (called “haustoria”) and extract its necessary growth elements. The active compounds of Cuscuta species include flavonoids, lignans, quinic acid and poly-saccharides. Flavonoids are kinds of effective antioxidants, and polysaccharides are the effective constituents to improve the immune system. Cuscuta epithymum is an important herbal medicine that is effective in the treatment of liver and kidney failure, sexual impotence and vision weakness. It also prevents abortion senescence and aging. C epithymum possesses anticancer, immuno-stimulatory, anti-oxidant and anti-osteoporotic activities.

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Cytotoxic effects ofCuscutaextract on human cancer cell lines

Cited by 10 publications

References 20 publications

Punicalagin and ellagic acid from pomegranate peel induce apoptosis and inhibits proliferation in human HepG2 hepatoma cells through targeting mitochondria

Punicalagin and ellagic acid from pomegranate peel induce apoptosis and inhibits proliferation in human HepG2 hepatoma cells through targeting mitochondria

Toxicity Effects of Chinese Herbal ‘Five-seeds’ Formulation on Human Kidney HEK-293 and Chang Liver Cells

A Review on the Botanical, Phytochemical and Pharmacological Characteristics of Cuscuta Spp.

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