Cytotoxic effects of NSL-1406, a new thienopyrimidine derivative, on leukocytes and osteoclasts

Optimization of labeled 125I- pyrimidine derivative and its biological evaluation

“…Due to the similarity of reported pyrimidine as potential cancer chemotherapeutic agents [4]. Pyrimidine derivative showed a higher and faster peak of brain uptake and a faster washout from the brain in the normal mice.…”

“…Therefore, many methods for the synthesis of substituted Pyrroles have been described in the literature (1,2). Design and synthesis of thieno [2, 3-d] pyrimidine as potential cancer chemotherapeutic agents have been extensively studied (4)(5)(6)(7)(8)(9)(10).Recently, some new pyridine, pyrimidine and their derivatives have been synthesized and used as analgesic, anticonvulsant and anti-parkinsonian agents (11)(12)(13)(14). Catalysts are used to improve the radiochemical yield and decrease the reaction time in isotopic exchange reaction especially in radioiodination reactions with the short lived 321 I isotope.…”

Synthesis of Some Novel Thieno[3,2-<i>d</i>]pyrimidines as Potential Cytotoxic Small Molecules against Breast Cancer

“…11) Literature screening revealed that many thienopyrimidine derivatives A, B and C have been developed and showed pronounced cytotoxic activity. [12][13][14][15][16][17][18][19][20] In particular, they are currently an important group of compounds that have anticancer activity especially against solid tumors (e.g., breast and ovarian). [21][22][23][24] Several mechanisms have been reported for the cytotoxic activity of thienopyrimidines including: inhibition of protein kinases (PKs) either as competitive or noncompetitive inhibitors.…”

Design, synthesis, characterization, quantum-chemical calculations and anti-inflammatory activity of novel series of thiophene derivatives

“…Among these heterocyclic compounds, multisubstituted 2-aminothiophenes are privileged structures as they have attracted considerable attention in designing of bioactive molecules and found in several biologically active and natural compounds[1-4] due to their broad spectrum of biological activities, such as antioxidant [5], antibacterial [6], antifungal [7], antitumor [8], antiinflammatory [9], antianxiety [10] and antitubercular activities. Additionally, Nfunctionalized morpholines have found to possess diverse pharmacological activities.…”