Cytotoxic Effects of Phosphonate-Functionalized Mesoporous Silica Nanoparticles

Menon, Nandita; Leong, David Tai

doi:10.1021/acsami.5b11741

Cited by 21 publications

(21 citation statements)

References 51 publications

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“…As shown in Table 2, the obtained IC 50 results show no significant cytotoxicity after 24 hours of treatment of blank MSN-NH 2 , MSN-Met, and MSN-FA on MCF-7 cells. It can be concluded that MSNs are biocompatible carriers and play no role in toxicity in MCF-7 cells 64,65. Overall, results attest to the potential of DTX/MSNs for DTX delivery by increasing the effectiveness of targeted delivery.…”

Section: Resultsmentioning

confidence: 62%

Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel

Khosravian¹,

Ardestani²,

Khoobi³

et al. 2016

OTT

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Mesoporous silica nanoparticles (MSNs) are known as carriers with high loading capacity and large functionalizable surface area for target-directed delivery. In this study, a series of docetaxel-loaded folic acid- or methionine-functionalized mesoporous silica nanoparticles (DTX/MSN-FA or DTX/MSN-Met) with large pores and amine groups at inner pore surface properties were prepared. The results showed that the MSNs were successfully synthesized, having good pay load and pH-sensitive drug release kinetics. The cellular investigation on MCF-7 cells showed better performance of cytotoxicity and cell apoptosis and an increase in cellular uptake of targeted nanoparticles. In vivo fluorescent imaging on healthy BALB/c mice proved that bare MSN-NH2 are mostly accumulated in the liver but MSN-FA or MSN-Met are more concentrated in the kidney. Importantly, ex vivo fluorescent images of tumor-induced BALB/c mice organs revealed the ability of MSN-FA to reach the tumor tissues. In conclusion, DTX/MSNs exhibited a good anticancer activity and enhanced the possibility of targeted drug delivery for breast cancer.

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Section: Resultsmentioning

confidence: 62%

Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel

Khosravian¹,

Ardestani²,

Khoobi³

et al. 2016

OTT

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“…MSNs had several peaks at 450, 800, and 1056 cm −1 because of the siliceous mesostructured framework. As their surface was functionalized with phosphonate groups in MSNsP, we observed a new band at 953 cm −1 and a broad peak from 3000 to 3600 cm −1 , reflecting phosphonate groups [39]. Two new peaks at 1639 cm −1 , and an intensive peak centered at 3355 cm −1 were presented in MSNsPCOL, corresponding to shifted peaks at 1542 and 3629 cm −1 for COL. Additional coating resulted in several new peaks, with bands at 698 and 946 cm −1 attributed to chitosan, glycine, or folic acid.…”

Section: Functional Group Determinationmentioning

confidence: 73%

Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles

AbouAitah

Hassan

Świderska-Środa

et al. 2020

Cancers

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Antimitotics are important anticancer agents and include the natural alkaloid prodrug colchicine (COL). However, a major challenge of using COL as an anticancer drug is its cytotoxicity. We developed a novel drug delivery system (DDS) for COL using mesoporous silica nanoparticles (MSNs). The MSNs were functionalized with phosphonate groups, loaded with COL, and coated with folic acid chitosan-glycine complex. The resulting nanoformulation, called MSNsPCOL/CG-FA, was tested for action against cancer and normal cell lines. The anticancer effect was highly enhanced for MSNsPCOL/CG-FA compared to COL. In the case of HCT116 cells, 100% inhibition was achieved. The efficiency of MSNsPCOL/CG-FA ranked in this order: HCT116 (colon cancer) > HepG2 (liver cancer) > PC3 (prostate cancer). MSNsPCOL/CG-FA exhibited low cytotoxicity (4%) compared to COL (~60%) in BJ1 normal cells. The mechanism of action was studied in detail for HCT116 cells and found to be primarily intrinsic apoptosis caused by an enhanced antimitotic effect. Furthermore, a contribution of genetic regulation (metastasis-associated lung adenocarcinoma transcript 1 (MALAT 1), and microRNA (mir-205)) and immunotherapy effects (angiopoietin-2 (Ang-2 protein) and programmed cell death protein 1 (PD-1) was found. Therefore, this study shows enhanced anticancer effects and reduced cytotoxicity of COL with targeted delivery compared to free COL and is a novel method of developing cancer immunotherapy using a low-cost small-molecule natural prodrug.

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“…Besides cytotoxicity, previous study also found that silica coating significantly reduce DNA damage induced by ZnO nanorods [51]. Comparison between ZnO NPs and SiO 2 NPs also found that ZnO NPs are more toxic [52, 53, 54, 55]. …”

Section: Resultsmentioning

confidence: 98%

Reducing ZnO nanoparticles toxicity through silica coating

Chia

Leong

2016

Heliyon

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ZnO NPs have good antimicrobial activity that can be utilized as agents to prevent harmful microorganism growth in food. However, the use of ZnO NPs as food additive is limited by the perceived high toxicity of ZnO NPs in many earlier toxicity studies. In this study, surface modification by silica coating was used to reduce the toxicity of ZnO NPs by significantly reducing the dissolution of the core ZnO NPs. To more accurately recapitulate the scenario of ingested ZnO NPs, we tested our as synthesized ZnO NPs in ingestion fluids (synthetic saliva and synthetic gastric juice) to determine the possible forms of ZnO NPs in digestive system before exposing the products to colorectal cell lines. The results showed that silica coating is highly effective in reducing toxicity of ZnO NPs through prevention of the dissociation of ZnO NPs to zinc ions in both neutral and acidic condition. The silica coating however did not alter the desired antimicrobial activity of ZnO NPs to E. coli and S. aureus. Thus, silica coating offered a potential solution to improve the biocompatibility of ZnO NPs for applications such as antimicrobial agent in foods or food related products like food packaging. Nevertheless, caution remains that high concentration of silica coated ZnO NPs can still induce undesirable cytotoxicity to mammalian gut cells. This study indicated that upstream safer-by-design philosophy in nanotechnology can be very helpful in a product development.

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Cytotoxic Effects of Phosphonate-Functionalized Mesoporous Silica Nanoparticles

Cited by 21 publications

References 51 publications

Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel

Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel

Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles

Reducing ZnO nanoparticles toxicity through silica coating

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