Cytotoxic effects of repin, a principal sesquiterpene lactone of russian knapweed

Robles, Mario; Wang, N.; Kim, R.; Choi, BongKyoo

doi:10.1002/(sici)1097-4547(19970101)47:1<90::aid-jnr10>3.0.co;2-e

Cited by 32 publications

(25 citation statements)

References 26 publications

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“…Repin was found to be highly cytotoxic to both Pc12 cells and mouse astrocytes in a dose-and time-dependent way. The cytotoxic effects were accompanied by depletion of glutathione, a rise in the level of reactive oxygen species and damage to cellular membranes (Robles et al, 1997). Both A-an B-ring modifications of the electrophilic exocyclic methylene group and the epoxy-ester moiety were performed, further demonstrating the importance of these functional group contributions to toxicity (Anand et al, 2003;Tukov et al, 2004).…”

Section: Antitumor and Cytotoxicmentioning

confidence: 77%

“…Acroptilon repens Evstratova et al, 1966;Rybalko et al (1975), Gonzalez et al (1977a), Rustaiyan et al (1981b), , Mallabaev et al (1982), Rustaiyan and Nazarians (1984), Nowak et al (1986a), Stevens et al (1990), Robles et al (1997) Centaurea adjarica Nowak et al (1989a Geppert et al (1983), Nowak et al (1986dNowak et al ( , 1996, Nowak (1990Nowak ( , 1992Nowak ( , 1993a et al, , Gonzalez et al (1977a, Rustaiyan et al (1981b), Mallabaev et al, 1982, Rustaiyan andNazarians (1984) Centaurea adjarica Nowak et al (1986dNowak et al ( , 1989aNowak et al ( , 1996 et al (1983), Nowak et al (1986dNowak et al ( , 1996, Nowak (1990Nowak ( , 1992Nowak ( , 1993a,b) Centaurea hyrcanica Evstratova et al, 1972, Rybalko et al (1975, Gonzalez et al (1977a) Centaurea hyssopifolia Gonzalez et al, 1974b, 1977a, Nowak et al (1986a et al (1977a, 1978b), Nowak et al (1986a et al (1989a, 1996), Nowak (1992) Centaurea solstitialis Merrill and Stevens (1985), Jakupovic et al…”

Section: Repinmentioning

confidence: 99%

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Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

et al. 2013

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Section: Antitumor and Cytotoxicmentioning

confidence: 77%

Section: Repinmentioning

confidence: 99%

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

et al. 2013

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“…In PC12 cells, repin induced OS, partially by conjugation with, and consequent depletion of, cellular GSH. The authors suggested that inhibited striatal DA release may be an early event in toxin-induced pakinsonism, leading to functional denervation, OS and ultimately degeneration of the nigrostriatal tract [109,110].…”

Section: Neuromelanin (Nm)mentioning

confidence: 84%

“…It was also recognized that a number of non-idiopathic parkinsonian syndromes are the result of exposure to environmental toxins (for instance, manganese). Robles et al [109,110] have recently described the cytotoxic effects of repin, a sesquiterpene lactone isolated from Russian knapweed (Centaurea repens). Chronic ingestion of repin by horses leads to equine nigropallidal encephalomalacia, a parkinsonian movement disorder.…”

Section: Neuromelanin (Nm)mentioning

confidence: 99%

Influence of neurotoxins and oxidative stress on the onset and progression of Parkinson’s disease

Foley

Riederer

2000

J Neurol

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It is generally accepted that progressive, irreversible and regionally specific neurodegeneration and the presence of Lewy bodies are the essential pathological hallmarks of idiopathic parkinsonism. The causes of these phenomena, however, remain to be elucidated. One of the leading hypotheses is that oxidative stress induced by reactive oxygen species (ROS), such as the hydroxyl radical, damages essential components of the neuron, resulting ultimately in cell death. Observations in the parkinsonian brain at post-mortem support this hypothesis; for example, widespread oxidative protein modification is evident. There are several potential sources of increased oxidative stress in Parkinson's disease, including mitochondrial dysfunction, increased free iron levels and impaired free radical defence mechanisms. Further, it is possible that glial, rather than neuronal, elements are primarily responsible for the initial increase in oxidative stress in the substantia nigra. It is likely that parkinsonism is the result of aberrations at multiple levels of neuronal function. Oxidative stress is no doubt one of the events involved in neurodegeneration, but is unlikely to be the initiating event. It is to be expected that the search for this event will continue for many years.

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“…In Montana, cattle avoided grazing in areas with ten percent or greater leafy spurge cover (Hein and Miller, 1992). Russian knapweed and yellow starthistle contain repin, a sesquiterpene lactone that causes mouth ulcers and brain lesions in horses (Cordy, 1978;Robles et al, 1997). St. Johnswort contains hypericin, which causes symptoms ranging from severe dermatitis to hyperthermia when ingested by sheep or cattle (Bourke and White, 2004).…”

Section: Toxicity or Repellency To Livestockmentioning

confidence: 99%

Classical biological control for the protection of natural ecosystems

Carruthers²,

et al. 2010

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Keywords: Invasive species Ecosystem function Insect pests Invasive plants Ecological restoration Biological control Natural ecosystems a b s t r a c tOf the 70 cases of classical biological control for the protection of nature found in our review, there were fewer projects against insect targets (21) than against invasive plants (49), in part, because many insect biological control projects were carried out against agricultural pests, while nearly all projects against plants targeted invasive plants in natural ecosystems. Of 21 insect projects, 81% (17) provided benefits to protection of biodiversity, while 48% (10) protected products harvested from natural systems, and 5% (1) preserved ecosystem services, with many projects contributing to more than one goal. In contrast, of the 49 projects against invasive plants, 98% (48) provided benefits to protection of biodiversity, while 47% (23) protected products, and 25% (12) preserved ecosystem services, again with many projects contributing to several goals. We classified projects into complete control (pest generally no longer important), partial control (control in some areas but not others), and ''in progress," for projects in development for which outcomes do not yet exist. For insects, of the 21 projects discussed, 62% (13) achieved complete control of the target pest, 19% (4) provided partial control, and 43% (9) are still in progress. By comparison, of the 49 invasive plant projects considered, 27% (13) achieved complete control, while 33% (16) provided partial control, and 49% (24) are still in progress. For both categories of pests, some projects' success ratings were scored twice when results varied by region. We found approximately twice as many projects directed against invasive plants than insects and that protection of biodiversity was the most frequent benefit of both insect and plant projects. Ecosystem service protection was provided in the fewest cases by either insect or plant biological control agents, but was more likely to be provided by projects directed against invasive plants, likely because of the strong effects plants exert on landscapes. Rates of complete success appeared to be higher for insect than plant targets (62% vs 27%), perhaps because most often herbivores gradually weaken, rather than outright kill, their hosts, which is not the case for natural enemies directed against pest insects. For both insect and plant biological control, nearly half of all projects reviewed were listed as currently in progress, suggesting that the use of biological control for the protection of wildlands is currently very active.

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Cytotoxic effects of repin, a principal sesquiterpene lactone of russian knapweed

Cited by 32 publications

References 26 publications

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

Influence of neurotoxins and oxidative stress on the onset and progression of Parkinson’s disease

Classical biological control for the protection of natural ecosystems

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