Cytotoxic Evaluation in HaCaT Cells of the Pa.7 Bacteriophage from Cutibacterium (Propionibacterium) acnes, Free and Encapsulated Within Liposomes

Bello, Daniela Torres Di; Narváez, Diana; Restrepo, Helena Groot de; Vives, Martha J.

doi:10.1089/phage.2022.0038

Cited by 1 publication

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“…The treatment of the acne disease is based on the combination of various products derived from retinoids, antibiotics, and hormonal antiandrogens, which takes a long time, can have side effects, be expensive, and not always effective. in this context, the evaluation of cytotoxicity of free and encapsulated in LSs Pa.7 bacteriophage from C. acnes in HaCaT cells is of interest [50]. LS encapsulated Pa.7 bacteriophage (Pseudomonas phage PA7, equivalent to Pa.7 bacteriophage) did not exhibited cytotoxicity to HaCaT cells, which are a spontaneously transformed aneuploid immortal keratinocyte cell line from the adult human skin.…”

Section: Cutibacterium Acnesmentioning

confidence: 99%

Prospects for the Creation of Liposomal Antimicrobials Based on Phages

Pylypenko

2023

Biotechnol. acta

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The emergence of many pathogenic microorganisms, which are resistant to known antibiotics, indicates the need to find new strategies to fight them. Aim. The article is devoted to the analysis of modern research on liposomal forms of phages as a promising strategy for fighting microbial infections. Methods. Analysis of modern national and foreign research devoted to the bacteriophage encapsulation into liposomes and the evaluation of the effecacy of this drug delivery system in antimicrobial therapy. Results. Bacteriophage encapsulation into liposomal nanoparticles protects phages from the negative effects of external factors, increases the period of circulation in the organism, ensures increased bioavailability of phage particles and, as a result, increases the efficacy of antimicrobial treatment. Liposomal forms of phages have demonstrated their effectiveness in fighting many common pathogenic bacteria, including Staphylococcus aureus, Klebsiella pneumoniae, Mycobacterium tuberculosis, Salmonella, etc. Conclusions. Liposomal phages have prospects as antimicrobial drugs, however, for their widespread use in clinical practice, preclinical and clinical studies are required to confirm their effecace and safety.

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Section: Cutibacterium Acnesmentioning

confidence: 99%

Prospects for the Creation of Liposomal Antimicrobials Based on Phages

Pylypenko

2023

Biotechnol. acta

View full text Add to dashboard Cite

show abstract

Cytotoxic Evaluation in HaCaT Cells of the Pa.7 Bacteriophage from Cutibacterium (Propionibacterium) acnes, Free and Encapsulated Within Liposomes

Cited by 1 publication

References 52 publications

Prospects for the Creation of Liposomal Antimicrobials Based on Phages

Prospects for the Creation of Liposomal Antimicrobials Based on Phages

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