Cytotoxic evaluation of new polyhydroxylated steroids from the Red Sea soft coral
            <i>Litophyton mollis</i>
            (Macfadyen, 1936)

Eissa, Ahmed H.; Abdel-Tawab, Asmaa M.; A.E. Hamed, El Sayed; El-Ablack, Fawzia Z.; N. Ayyad, Seif-Eldin

doi:10.1080/14786419.2023.2284259

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“…In continuation of our recent exploration of bioactive natural products derived from marine organisms, [24] our researchers investigated the CH 2 Cl 2 /MeOH crude extract of Nephthea mollis soft coral collected from the Red Sea coast of Hurghada, Egypt. During our investigation, we isolated a new C 21 glycerol ether and identified three known monoalkyl glycerol ethers (m‐AGEs): chimyl alcohol, batyl alcohol, and 3‐(icosyloxy)propane‐1,2‐diol (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

New Cytotoxic Monoalkyl Glycerol Ether from the Red Sea Soft Coral Nephthea mollis

Eissa,

Abdel‐Tawab,

Hamed

et al. 2023

Chemistry & Biodiversity

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A new monoalkyl glycerol ether, 3‐(n‐henicosyloxy) propane‐1,2‐diol (1), was isolated from the CH2Cl2/MeOH crude extract of the Red Sea soft coral Nephthea mollis. Additionally, three known related analogues were identified: chimyl alcohol (2), batyl alcohol (3), and 3‐(icosyloxy) propane‐1,2‐diol (4). The chemical structure of 3‐(n‐henicosyloxy) propane‐1,2‐diol was determined using advanced spectroscopic analyses, including 1D, 2D Nuclear Magnetic Resonance (NMR), Electron Ionization mass spectra (EI‐MS), and High‐Resolution Electron Spray Ionization mass spectra (HRESIMS) analyses. Furthermore, the identification of chimyl alcohol, batyl alcohol and 3‐(icosyloxy) propane‐1,2‐diol was achieved by studying their EI mass fragmentation analyses and comparing their mass data with those previously reported in the literature. The cytotoxic activity of the Nephthea mollis crude extract and 3‐(n‐henicosyloxy) propane‐1,2‐diol was evaluated against five human cancer cell lines: HepG2 (hepatocellular carcinoma), MCF‐7 (breast carcinoma), NCI‐1299 (lung carcinoma), HeLa (cervical cancer cell), and HT‐29 (colon adenocarcinoma). Moreover, 3‐(n‐henicosyloxy) propane‐1,2‐diol revealed moderate cytotoxicity against the HeLa cell line with an IC50 value of 24.1 μM, while showing inactivity against the remaining cell lines (IC50 >100 μM).

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Section: Introductionmentioning

confidence: 99%