Cytotoxic lignans from fruits of Cleistanthus tonkinensis

Nguyen, Lam Hong; Vu, Van Nam; Thi, Dao; Tran, Viet Hung; Litaudon, Marc; Roussi, Fanny; Nguyễn, Văn Hùng; Chau, Van Minh; Thi, Huong Doan; Pham, Van Cuong

doi:10.1016/j.fitote.2019.104432

Cited by 12 publications

(8 citation statements)

References 21 publications

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“…NOE correlation of H-7 (δ 5.23) with H-8′ (δ 2.85) indicated that the relationship for H-8/H-8′ was trans. This was also supported by the Δδ Hα-9′-Hβ-9′ value of 0.35 (this value ≥ 0.2 for trans, and ≈ 0 for cis) [ 20 ]. The ECD spectrum of 1 ( Figure S8 ) was in good agreement with the ECD spectrum of the 7R,8S,8′R-isomer cleistonkiside B [ 20 ].…”

Section: Resultsmentioning

confidence: 73%

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Lignans from the Roots and Rhizomes of Dysosma versipellis and Their Cytotoxic Activities

et al. 2023

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One new dibenzyltyrolactone lignan dysoslignan A (1), three new arylnaphthalide lignans dysoslignan B–C (2–4), along with fourteen known metabolites (5–18), were isolated from the roots and rhizomes of Dysosma versipellis. Their structures and stereochemistry were determined from analysis of NMR spectroscopic and circular dichroism (CD) data. Compound 2 represents the first report of naturally occurring arylnaphthalide lignan triglycoside. The cytotoxic activities of all isolated compounds were evaluated against A-549 and SMMC-7721 cell lines. Compounds 7–10 and 14–16 were more toxic than cisplatin in two tumor cell lines. This investigation clarifies the potential effective substance basis of D. versipellis in tumor treatment.

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Section: Resultsmentioning

confidence: 73%

“…This was also supported by the Δδ Hα-9′-Hβ-9′ value of 0.35 (this value ≥ 0.2 for trans, and ≈ 0 for cis) [ 20 ]. The ECD spectrum of 1 ( Figure S8 ) was in good agreement with the ECD spectrum of the 7R,8S,8′R-isomer cleistonkiside B [ 20 ]. So the 7R, 8S, and 8′R-configurations were assigned for 1 .…”

Section: Resultsmentioning

confidence: 73%

Lignans from the Roots and Rhizomes of Dysosma versipellis and Their Cytotoxic Activities

et al. 2023

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“…Cleistanthus sumatranus is an evergreen tree species that thrives in South China and Southeast Asia . The Cleistanthus genus is rich in beneficial phytochemicals such as phenolic compounds, lignans, alkaloid glucosides, and terpenoids, delivering a vast array of bioactivities such as anticancer and antioxidant properties. − Consequently, the genus has long attracted the interest of medicinal chemists and pharmacologists. , …”

Section: Introductionmentioning

confidence: 99%

Antiradical Activity of Lignans from Cleistanthus sumatranus: Theoretical Insights into the Mechanism, Kinetics, and Solvent Effects

Bay,

Nam,

Hoa

et al. 2023

ACS Omega

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Sumatranus lignans (SL) isolated from Cleistanthus sumatranus have demonstrated bioactivities, e.g., they were shown to exhibit immunosuppressive properties in previous research. Their structure suggests potential antioxidant activity that has not attracted any attention thus far. Consistently, a comprehensive analysis of the antioxidant activity of these compounds is highly desirable with the view of prospective medical applications. In this work, the mechanism and kinetics of the antiradical properties of SL against hydroperoxyl radicals were studied by using calculations based on density functional theory (DFT). In the lipid medium, it was discovered that SL reacted with HOO • through the formal hydrogen transfer mechanism with a rate constant of 10 1 −10 5 M −1 s −1 , whereas in aqueous media, the activity primarily occurred through the sequential proton loss electron transfer mechanism with rate constants of 10 2 −10 8 M −1 s −1 . In both lipidic and aqueous environments, the antiradical activity of compounds 6 and 7 exceeds that of resveratrol, ascorbic acid, and Trolox. These substances are therefore predicted to be good radical scavengers in physiological environments.

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“…They can be traced to the effects of numerous marine compounds from different classes of constituents such as alkaloids, terpenoids, steroids, flavonoids, peptides, proteins, polyphenols, carotenoids, vitamins, tocopherols, tocotrienols, peptides, carbohydrates, etc. Not only marine compounds, but also terrestrial plant constituents have anticancer properties [ 1 , 2 , 3 , 4 , 5 ], as well as a plethora of other biological activities. The activities of these compounds have been screened in various disease conditions including cancer using in vivo or in vitro methods, and the documented evidence of these activities is reviewed regularly [ 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review

et al. 2021

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Secondary metabolites from marine sources have a wide range of biological activity. Marine natural products are promising candidates for lead pharmacological compounds to treat diseases that plague humans, including cancer. Cancer is a life-threatening disorder that has been difficult to overcome. It is a long-term illness that affects both young and old people. In recent years, significant attempts have been made to identify new anticancer drugs, as the existing drugs have been useless due to resistance of the malignant cells. Natural products derived from marine sources have been tested for their anticancer activity using a variety of cancer cell lines derived from humans and other sources, some of which have already been approved for clinical use, while some others are still being tested. These compounds can assault cancer cells via a variety of mechanisms, but certain cancer cells are resistant to them. As a result, the goal of this review was to look into the anticancer potential of marine natural products or their derivatives that were isolated from January 2019 to March 2020, in cancer cell lines, with a focus on the class and type of isolated compounds, source and location of isolation, cancer cell line type, and potency (IC50 values) of the isolated compounds that could be a guide for drug development.

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Cytotoxic lignans from fruits of Cleistanthus tonkinensis

Cited by 12 publications

References 21 publications

Lignans from the Roots and Rhizomes of Dysosma versipellis and Their Cytotoxic Activities

Lignans from the Roots and Rhizomes of Dysosma versipellis and Their Cytotoxic Activities

Antiradical Activity of Lignans from Cleistanthus sumatranus: Theoretical Insights into the Mechanism, Kinetics, and Solvent Effects

Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review

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