Cytotoxic Lymphocytes: The Role in Inflammation in Patients With Chronic Obstructive Pulmonary Disease Exacerbation and Remission

Raspopina, N. A.; Шуганов, Е. Г.; Палеев, Ф. Н.; Салмаси, Жеан Мустафаевич; Шуганов, А. Е.

doi:10.18786/2072-0505-2014-35-49-53

Cited by 1 publication

(5 citation statements)

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“…The CD4 decreased during exacerbation and increased above the established norm during stable in COPD with the accompanying significant increase in CD8 (the CD4/CD8 index did not exceed 1.15 even in stable disease). This indicates the predominantly cytotoxic mechanisms of the immune system action manifested by excessive T-cells stimulation [5,[12][13][14]. Our study has shown that this process in COPD does not depend on the stage of the disease (Table 1).…”

Section: Discussionmentioning

confidence: 56%

“…Each of these cells carries on the surface membrane glycoproteins acting as co-receptors of intercellular interactions and being markers of quantitative and functional features of the cells. Thus, T-cell (CD3), helper-inducer (CD4), and suppressor-cytotoxic (CD8) lymphocytes subpopulations are divided [5,6]. The CD3 antigen is a component of a membrane-associated structure, the so-called antigen-specific T-cell receptor (TcR/CD3) initiating antigen-dependent T-cell activation [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…They stimulate immune cells by producing lymphokines [7,10], which realize most of the B-cells functions [8,10,11]. The main function of CD8 cells is cytotoxicity; they are killer cells, acting by direct cytolysis of cellular structures affected by antigen-induced immunological reaction [5,12]. Cells are destructed by complete or partial cell dissolution; thus, CD8 cells play a leading role in antiviral, antitumor, and transplant immunity [6,7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Apoptosis is a natural completion of the immune response aimed at removal of cells that have fulfilled their protective function and restoration of the initial state of the immune system [5,8]. In a number of immunopathological diseases, induction of the activation process is impaired accompanied by a steady progression of inflammation [11,20].…”

Section: Discussionmentioning

confidence: 99%

“…COPD patients showed no change in CD25/CD95 ratio regardless of disease stage, and the HLA-DR/CD95 ratio was lower than in healthy individuals. This seems to be related to the high blood CD95 lymphocytes characteristic of immune system activation [5,20] in COPD and a lower lymphocyte apoptosis than in asthma because of the low content of lymphocytes expressing FasL (CD178).…”

Section: Healthy Blood Donorsmentioning

confidence: 99%

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Chronic Obstructive Pulmonary Disease and Asthma Differentiation by Immunologic Features

Распопина¹,

Grigoryevich²,

Mustafaevich³

et al. 2021

AJIM

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Among respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD) are the most common. Considering that the leading clinical symptom of these diseases is bronchial obstruction, as well as a large number of phenotypes in both asthma and COPD, especially when patients have signs of both diseases, problems arise in differential diagnosis. Immune inflammation plays an important pathological role in chronic obstructive pulmonary disease and asthma. Lymphocyte is the principal immune cell capable of recognizing a particular molecular determinant of the organic structure disorder. We aimed to search for specific features of the immune response in these diseases. Therefore, we determined in peripheral blood the relative and absolute content of lymphocytes expressing the CD3, CD4, CD16, CD54, CD56, CD72, HLA-DR, CD95, and CD178 antigens. The study found that low CD8, CD16 and high CD 178 lymphocytes are characteristic of patients with asthma, and high CD8, CD16 and low CD 178 are typical in COPD. Over 4-5 times increase in CD54 is characteristic of asthma, while in COPD the index exceeded the norm by only 50%. An important feature of COPD is a low apoptosis irrespective of the stage of the disease. These immunologic features can be additional criteria for asthma and COPD differentiation.

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Section: Discussionmentioning

confidence: 56%