Cytotoxic‐mediated spontaneous regression of inflammatory cutaneous metastases of breast carcinoma

Tomasini, Carlo

doi:10.1111/cup.13694

Cited by 2 publications

(2 citation statements)

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“…In five of seven reported cases [4,6,[8][9][10], complete or nearly complete disappearance of tumor cells in the primary tumor and/or metastatic lymph nodes with infiltration of inflammatory cells was observed on pathological examination of surgical specimens. On the other hand, in two of seven reported cases [7,11], regression of the primary tumor and/or metastatic lesion was observed on visual examination or CT. Although our patient's breast tumor also disappeared according to physical examination and ultrasonography, the tumor reappeared 8 months later in the same place.…”

Section: Discussionmentioning

confidence: 85%

“…In a review of SR among 741 cases of cancer, only 43 cases (5.8%) of breast cancer exhibited regression [3]. We found only seven case reports of SR of breast cancer in an English literature search of PubMed from 1994 to July 2020 using the search words "spontaneous regression", "spontaneous remission", "breast cancer" and "breast carcinoma" (Table 1) [4,[6][7][8][9][10][11]. To the best of our knowledge, this is the first report of temporary SR of breast cancer followed by reappearance.…”

Section: Discussionmentioning

confidence: 99%

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Temporary spontaneous regression of male breast cancer: a case report

et al. 2020

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Background Spontaneous regression (SR) of a malignant tumor is the partial or complete disappearance of primary or metastatic tumor tissue in the absence of treatment, which can be temporary or permanent. Here, we report an extremely rare case of male breast cancer that exhibited temporary SR followed by reappearance 8 months after tumor disappearance. Case presentation A 70-year-old man presented at our hospital with a primary complaint of pain and a lump in his left breast. Ultrasonography revealed a hypoechoic lesion measuring 12 mm × 10 mm × 8 mm. Fine-needle aspiration cytology revealed numerous necrotic and degenerated cells and few sheet-like clusters of atypical ductal epithelial cells. The atypical cells had mildly enlarged nuclei with nucleoli, were focally overlapped and formed tubular patterns. The cytological diagnosis indicated a suspicion of malignancy. Core needle biopsy (CNB) revealed necrotic and degenerated cells with microcalcification. The pathological diagnosis was indeterminate because there was no area of viable atypical cells. An excisional biopsy of the left breast lesion was scheduled one month later. However, it was difficult to detect the tumor during physical examination and ultrasonography performed 1 month after the patient’s first visit. The operation was canceled, and the patient received follow-up observation. After 8 months of follow-up, ultrasonography and computed tomography (CT) revealed reappearance of a 0.6-cm-diameter breast tumor in the same place. CNB was performed again and revealed invasive ductal carcinoma. A total mastectomy with sentinel lymph node biopsy was performed 13 months after the first tumor disappeared. Histopathological examination revealed invasive cribriform carcinoma without sentinel lymph node metastasis. The patient did not have any complications, and adjuvant therapy with tamoxifen was started. The patient was alive without recurrence 7 months after surgery. Conclusions Temporary SR followed by tumor reappearance can occur in breast cancer cases, and it is important to follow patients even if their breast tumor has seemingly disappeared. When breast tumors disappear without treatment, clinicians must be aware of the possibility of SR of cancer and should follow the patient for early detection of tumor reappearance.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Temporary spontaneous regression of male breast cancer: a case report

et al. 2020

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Breast carcinoma with spontaneous regression after needle biopsy: a case report and literature review

Sasamoto¹,

Yamada²,

Oshi³

et al. 2023

Gland Surg

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Background Spontaneous regression (SR) of cancer is a rare condition in which the cancer partially or completely disappears without treatment. We report a case of breast cancer with tumor regression and spontaneously induced T-cell-mediated immunological responses in a surgical specimen obtained after core needle biopsy (CNB). Case Description A 52-year-old woman presented with a mass in the right breast. Mammography showed a high-density mass with fine serrated margins in the right lower outer quadrant. Breast ultrasonography showed an irregular hypoechoic mass with a maximum diameter of 22 mm. CNB was performed and revealed an invasive ductal carcinoma with negative estrogen receptors, positive progesterone receptors, and negative HER2 (1+). The Ki67 index was 70% to 80%. Luminal B cT2N1M0 stage IIB right breast cancer was diagnosed. Although preoperative chemotherapy was considered, surgery was selected because of her history of schizophrenia. She underwent right mastectomy and axillary lymph node dissection. A postoperative pathological analysis revealed a 20 mm × 10 mm × 10 mm mass. However, most areas of the mass regressed and appeared as necrotic tissue with no obvious invasive areas. Only intraductal extension was observed in one glandular duct. Axillary lymph node metastases were not observed. These results suggest that the tumor may have spontaneously regressed, possibly because of the CNB procedure. Follow-up without treatment was performed, and no recurrence occurred during 2 years after surgery. Conclusions Invasive ductal carcinoma may spontaneously regress after preoperative CNB.

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Cytotoxic‐mediated spontaneous regression of inflammatory cutaneous metastases of breast carcinoma

Cited by 2 publications

References 35 publications

Temporary spontaneous regression of male breast cancer: a case report

Temporary spontaneous regression of male breast cancer: a case report

Breast carcinoma with spontaneous regression after needle biopsy: a case report and literature review

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