Cytotoxic molecule-positive classical Hodgkin's lymphoma: a clinicopathological comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type

Asano, Naoki; Kinoshita, Tomohiro; Tamaru, Jun Ichi; Ohshima, Koichi; Yoshino, Tadashi; Niitsu, Nozomi; Tsukamoto, Norifumi; Hirabayashi, Kaoru; Izutsu, Koji; Morishima, Yasuo; Nakamura, Shigeo

doi:10.3324/haematol.2011.041079

Cited by 22 publications

(20 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…on May 10, 2018. by guest www.bloodjournal.org From could show that GrB protein expression was high in one index case of this cluster. Our data corroborate the finding that, in a subgroup of cases, HRS cells express cytotoxic granule protein such as TIA-1, 23,35,36 and add further evidence that specific expression patterns resembling T/NK cells might contribute to CHL pathogenesis. 25 Herein, we present a genome-wide analysis of copy number changes correlated with gene expression levels in primary HRS cells.…”

Section: Gene Expression Profiling Of Hrs Cells 3537supporting

confidence: 80%

Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma

Steidl

Diepstra

Lee

et al. 2012

Blood

133

131

View full text Add to dashboard Cite

Section: Gene Expression Profiling Of Hrs Cells 3537supporting

confidence: 80%

Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma

Steidl

Diepstra

Lee

et al. 2012

Blood

133

131

View full text Add to dashboard Cite

“…In CHL, there are several poor prognostic factors, including CTM expression, 8 EBV infection, 9 and marked infiltration of CD68-positive macrophages, 10 which were all observed in the current case. In addition, the reasons for the fulminant clinical course in the current case were likely associated with the severe angiodestruction revealed by autopsy.…”

Section: Discussionsupporting

confidence: 61%

A fulminant case of classical Hodgkin lymphoma: A diagnostic dilemma of Epstein‐Barr virus‐positive large B‐cell neoplasms

Ichimata

Kobayashi

Ohya

et al. 2019

Pathology International

View full text Add to dashboard Cite

We report a fulminant case of classical Hodgkin lymphoma (CHL). The patient died only approximately 2 months after the onset of subjective symptoms. Autopsy specimens revealed atypical cells resembling Hodgkin and Reed‐Sternberg (HRS) cells in a rich inflammatory background in various organs. There were marked, characteristic angiodestructive lesions from infiltrating HRS‐like cells and numerous macrophages. The HRS‐like cells were infected with Epstein‐Barr virus (EBV), immunohistochemically positive for PAX5 and CD30, and negative for CD3, CD20, and ALK. Most B‐cell markers other than PAX5 were negative, and the HRS‐like cells also expressed cytotoxic molecules. Monoclonal rearrangement of immunoglobulin heavy chain was detected by PCR analysis. According to the 2016 WHO classification, we diagnosed mixed cellularity CHL. However, EBV‐positive diffuse large B‐cell lymphoma (DLBCL), not otherwise specified and EBV‐positive B‐cell lymphoma, unclassifiable with features intermediate between DLBCL and CHL were considered as differential diagnoses because both tumors are aggressive EBV‐positive large B‐cell neoplasms with reactive inflammatory cells and sometimes contains HRS‐like cells. The clinical condition of the current case was closer to these two entities than to CHL. A diagnosis of EBV‐positive large B‐cell neoplasms was difficult because of overlapping morphological and immunohistochemical characteristics, but should be considered for prognosis.

show abstract

“…26, 27 Peripheral T cell lymphoma is another mimicker of mixed cellularity classical Hodgkin lymphoma because the former often shows Reed-Sternberg like cells, as seen in at least two cases of the present study. 28 It is to note that, the cases which were initially diagnosed as Hodgkin lymphoma by histopatholgy and/or immunohistochemistry but later diagnosed as peripheral T cell lymphoma by FCI, were unresponsive to the conventional ABVD therapy but responded promptly upon the administration of appropriate therapy for peripheral T cell lymphoma in the light of FCI diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Flow cytometry of lymph node aspirate can effectively differentiate the reactive lymphadenitis from the nodal non-Hodgkin lymphoma

Dey

Chakravarty

Kamal

2017

Bangabandhu Sheikh Mujib Medical University Journal

View full text Add to dashboard Cite

Lymphoma is a common malignancy worldwide affecting both children and adults. In Bangladesh, non-Hodgkin lymphoma (NHL) is relatively common and contributing to 7% of total cancer reported 1 as compared to 4% in USA. 2 Nodal lymphoma is rather prevalent in Bangladesh; for instance, lymphoma constitutes about 6% of all the cases of cervical lymphadenopathy persisting for more than three weeks. 3 Although fine needle aspiration cytology can diagnose almost all the cases of reactive lymphadenitis, only up to about 86% cases of NHL can be correctly identified by cytology alone. 4Fine needle aspiration cytology is accepted in recurrence lymphoma; primary diagnosis and classification of NHLs are usually made by histological examination and till date, considered to be the gold standard. Worldwide, many centers have reported fine needle aspiration cytology show relatively high sensitivity and specificity in the diagnosis of lymphomas when used in conjunction with other ancillary techniques in last 15 years. 5, 6 Despite this, nonHodgkin lymphoma diagnosis of on fine needle aspiration material has remained controversial. 7-9 Even though architectural and morphologic feature continues to be important parameters in World Health Organization's classifycation of hematopoietic and lymphoid tumors, lymphoma diagnosis is now routinely based on combined information from clinical manifestations, histomorphologic features, immunophenotype and genotype. 10, 11, 12 Flow cytometric immunophenotyping offers many advantages in the analysis of fine needle aspiration materials for lymphoma diagnosis. Moreover, it requires small number of cells and is also suitable for cells already in suspension. It is very sensitive immunophenotyping technique, and can detect aberrant cells even 1/10,000 cells. 13 Thus, it almost replaced the classic immunocytochemistry. 14 As in immunocytochemistry only one antigen can be assessed per cell at a time, it is rather time consuming. Large number of specific monoclonal anti-bodies combining four or more fluorochromes can precisely define the cell profile and neoplastic nature of lymphoid cells make FCI is a more sensitive, specific and swift diagnostic tool than is immunocytochemistry. 13, 15-17Indeed FCI evaluates several antigens on one cell (including cytoplasmic antigens), and can | Original | Article | AbstractThe purpose of the present study was to compare the routine cytology, histology, immunohistochemistry and flow cytometry in the diagnosis of nodal lymphoma cases. Thirty five cases of clinically suspected lymphoproliferative disorder were included in this study. After preparation of smears from the fine needle aspirates on the glass slides for cytology, the residual material was processed for flow cytometric immunophenotyping accordingly. Subsequently, histopathology and immunohistochemistry findings of selected cases of lymph node biopsy were correlated to confirm and compare the diagnosis. Flow cytometric immunophenotypes of most of the cases corresponded to the histological and immunohistochem...

show abstract

Cytotoxic molecule-positive classical Hodgkin's lymphoma: a clinicopathological comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type

Cited by 22 publications

References 30 publications

Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma

Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphoma

A fulminant case of classical Hodgkin lymphoma: A diagnostic dilemma of Epstein‐Barr virus‐positive large B‐cell neoplasms

Flow cytometry of lymph node aspirate can effectively differentiate the reactive lymphadenitis from the nodal non-Hodgkin lymphoma

Contact Info

Product

Resources

About