Cytotoxic Potencial Acetogenins ofAnnonaGenus

Abstract

Cytotoxic Potencial Acetogenins of Annona GenusAbstract: Over the centuries, nature has contributed to the basic needs of human beings. In particular, plants have cooperated as a source of drugs for the treatment of a broad spectrum of diseases because of the structural diversity of secondary metabolites. With strict attention to antineoplastic therapy, the search for anticancer drugs has increased in order to meet more specific and selective treatments. The acetogenins (ACGs), a class of secondary metabolites found exclusively in the family Annonaceae, are substances of great importance due to their well-known cytotoxic potency in human tumor cell lines in vitro, which can be exploited in designing anticancer agents. Among the 150 genera of Annonaceae family, genus Annona is in which is recorded the highest number of these substances. In order to identify the therapeutic potential and future directions for research, the purpose of this review is to provide data pertaining to the studies of cytotoxicity in vitro in cell lines of human cancer of isolated ACGs of Annona species in the period between 1989 and 2012 as well as basic information regarding the phytochemical studies of the same.

Características nutricionais e funcionais do marolo (Annona crassiflora Mart.)

“…Esta revisão não abordou possíveis aspectos citotóxicos do marolo, quando consumido em excesso. Porém, faz-se necessário ressaltar a presença na sua composição de algumas acetogeninas (acetogeninas tetrahidrofurânicas ou acetogeninas de Annonaceae), sendo estas uma classe de compostos derivados de ácidos graxos de cadeia longa, cujo espectro de atividade biológica inclui propriedades inseticidas, anti-helmínticas e anticancerígenas (LIMA et al, 2012;PAES et al, 2016). Porém, ainda desconhece a concentração de moléculas potencialmente citotóxicas das acetogeninas e os metabólitos da família Annonaceae, visando a seguridade ao consumo humano (GAVIRIA CALLE; ARIAS; HERNANDEZ, 2018).…”