Cytotoxic potentials of silibinin assisted silver nanoparticles on human colorectal HT-29 cancer cells

Jackson, Kiren; Ezhilarasan, Devaraj; Thangavelu, Lakshmi; Rajeshkumar, S.; Dua, Kamal; Chellappan, Dinesh Kumar; Subramanian, R.

doi:10.6026/97320630016817

Cited by 5 publications

(2 citation statements)

References 56 publications

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“…From the dried ginger copper nanoparticles were synthesised and these were characterised by UV-vis spectroscopy and exhibited potent antimicrobial activity against common oral pathogens [32]. In their study, the approach on green synthesis of iron nanoparticles by using dried ginger can provide pharmacological evidence of antioxidant activity [33]. Previous studies have shown that adding metal nanoparticles to various materials will improve the antimicrobial activity [11,34].…”

Section: Resultsmentioning

confidence: 99%

Controlling Oral Pathogens using Ficus Benghalensis Mediated Silver Nanoparticles

Thirumagal

Jeevitha

Rajeshkumar

et al. 2021

JPRI

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Aim: To find antimicrobial property of Ficus benghalensis mediated silver nanoparticles (AgNPs) Introduction: Nanoparticles have been studied in recent years because of certain properties like physical, chemical, electronic, thermal, magnetic, optical, dielectric and biological. This study was conducted in order to evaluate antimicrobial properties of F. benghalensis mediated AgNPs. Materials and Methods: In this study, extract of F. benghalensis was used to synthesize silver nanoparticles characterized using UV- visible spectrophotometer, Fresh F. benghalensis mediated AgNPs show excellent antimicrobial activity against oral pathogens, Staphylococcus aureus, Streptococcus mutans, Enterococcus faecalis. and Candida albicans. Results: F. benghalensis mediated AgNPs showed antimicrobial activity against gram positive S. aureus with a zone of inhibition of 16.22 ± 0.31 mm at the concentration of 100 μl. The zone of inhibition against S. mutans was 12.14 ± 0.21 mm followed by zone of inhibition against E. faecalis was 12.12 ± 0.2 mm and antimicrobial activity against C. albicans showed a zone of inhibition of 14.02 ± 0.24 mm at the concentration of 100 μl. The zone of inhibition of the nanoparticles was shown to be increased with increase in concentration against all the pathogens and the maximum inhibition was shown against S. aureus. Conclusion: Overall, antimicrobial activity was seen to be increased with increase in concentration. Thus there was potent antimicrobial activity in F. benghalensis mediated AgNPs which could be beneficial when applied in treatment of infectious oral diseases in future.

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Section: Resultsmentioning

confidence: 99%

Controlling Oral Pathogens using Ficus Benghalensis Mediated Silver Nanoparticles

Thirumagal

Jeevitha

Rajeshkumar

et al. 2021

JPRI

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“…Different parts of the F. benghalensis how medicinal properties [8,11]. Leaves are used for ulcers, aerial roots are used in gonorrhea, seeds and fruits are used for dysentery, diarrhea and diabetes [12] [16,17]. Such that the roots of Ficus species can be used to treat the toothache.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Mouthwash using Ficus benghalensis Assisted Silver Nanoparticles and a Comparative Analysis of Its Antimicrobial Activity

Rangeela

Jeevitha

Rajeshkumar

et al. 2021

JPRI

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Aim: The aim of this study is to prepare a mouthwash using Ficus benghalensis mediated silver nanoparticles (Ag NPs) and analysing its antimicrobial activity against oral pathogens Introduction: Nanotechnology deals with the particles which are less than 100 nm and have important roles in medicines, industries, drug gene delivery. Different parts of the F. benghalensis show medicinal properties. Leaves are used for ulcers, aerial roots are used in gonorrhoea, seeds and fruits are used for dysentery, diarrhoea and diabetes. F. benghalensis have been reported to have immunomodulatory, antibacterial activity and are used to treat toothache. Materials and methods: In the present study, the silver nanoparticles were synthesized from Ficus benghalensis plant extract. The preparation of plant extract was done using commercially available F. benghalensis leaves powder for the synthesis process. The mouthwash was prepared using 1 mM of silver nitrate. The prepared nanoparticles were confirmed using a UV-vis spectrophotometer. Different concentrates of the synthesised Ficus benghalensis mediated silver nanoparticles were tested against Staphylococcus aureus, Streptococcus mutans, Enterococcus faecalis and Candida albicans using agar well diffusion method and MIC will be determined. Results: It has been observed that the antimicrobial effect of the prepared Ag NPs was almost similar against all the organisms used in the study with a maximum zone of inhibition against Staphylococcus aureus. It has also been observed that the antimicrobial activity of the AgNPs increased with increasing concentration. Conclusion: As the synthesised F. benghalensis assisted silver nanoparticle mouthwash showed potent antimicrobial activity in vitro against the oral microbes: S. aureus, S. mutans, E. faecalis, C. albicans, in vivo studies are needed further to evaluate the antimicrobial effect.

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Flavonoids nanostructures promising therapeutic efficiencies in colorectal cancer

Hassani

Maghsoudi

Fattahi

et al. 2023

International Journal of Biological Macromolecules

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Cytotoxic potentials of silibinin assisted silver nanoparticles on human colorectal HT-29 cancer cells

Cited by 5 publications

References 56 publications

Controlling Oral Pathogens using Ficus Benghalensis Mediated Silver Nanoparticles

Controlling Oral Pathogens using Ficus Benghalensis Mediated Silver Nanoparticles

Preparation of Mouthwash using Ficus benghalensis Assisted Silver Nanoparticles and a Comparative Analysis of Its Antimicrobial Activity

Flavonoids nanostructures promising therapeutic efficiencies in colorectal cancer

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