Cytotoxic steroidal glycosides from the roots of Paris verticillata M.Bieb

Liu, Yang; Tang, Na; Zhang, Qian; Qiu, Pengcheng; Tang, Hai‐Feng; Lu, Yang; Zhang, Bang-Le

doi:10.1016/j.phytol.2023.01.006

Cited by 2 publications

(1 citation statement)

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“…Compounds 1and 2 [30] Compounds 1 and 2 (each 2 mg) were heated with 2 M HCl (2 mL) at 90 °C for 5 h. The reaction mixture was partitioned with EtOAc (3×2 mL). The aqueous layer was concentrated and dissolved in 1 mL of anhydrous pyridine and treated with 1 mg of l-cysteine methyl ester hydrochloride.…”

Section: Acidic Hydrolysis and Gc Analysis Of The Sugar Moieties Inmentioning

confidence: 99%

Polyhydroxylated Spirostanol Saponins from the Rhizomes of Paris dulongensis

Jia,

Yang,

Yang

et al. 2024

Chemistry & Biodiversity

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Three new polyhydroxylated spirostanol steroidal saponins, dulongenosides B–D (2–4), along with 14 known compounds, dulongenoside A (1), padelaoside B (5), parisyunnanoside G (6), polyphyllin D (7), ophiopogonin Cʹ (8), formosanin C (9), dioscin (10), paris saponin VII (11), paris H (12), parisyunnanoside I (13), protodioscin (14), proprotogracillin (15), crustecdysone (16), and stigmasterol‐3‐O‐β‐d‐glucopyranoside (17), were isolated from the rhizomes of Paris dulongensis (Melanthiaceae). Their chemical structures were elucidated based on extensive analyses of NMR and MS data and acidic hydrolyses. The isolates were evaluated for their cytotoxicity to five human cancer cell lines (HL‐60, SW480, MDA‐MB‐231, A549, and A549/Taxol) and the normal human bronchial epithelial cell line BEAS‐2B by the MTS test. Compounds 7–12 and 14 showed cytotoxic activity, with IC50 values ranging from 0.20 to 4.35 μM. Proprogracillin selectively inhibited A549(IC50 = 0.58 μM) and A549/Taxol (IC50 = 0.74 μM) cells, with no significant cytotoxic activity against HL‐60, SW480, MDA‐MB‐231, or BEAS‐2B cells, with IC50 values greater than 40 μM.

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Section: Acidic Hydrolysis and Gc Analysis Of The Sugar Moieties Inmentioning

confidence: 99%