Cytotoxic T cell activity against peptides of Hu protein in anti-Hu syndrome

Tanaka, Masami; Yoshie, Maruyama; Sugie, Miho; Motizuki, Hitoshi; Kamakura, Keiko; Tanaka, Keiko

doi:10.1016/s0022-510x(02)00157-0

Cited by 48 publications

(36 citation statements)

References 28 publications

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“…Anti-nucleus of the systemic organ antibody, anti-undetermined neuro-histology antibody, anti-ganglioside antibodies, and anti-voltage gated potassium channel antibody were also negative. The patient had HLA B51, one of the HLA B7 supertypes, consistent with a previous report (8).…”

Section: Case Reportsupporting

confidence: 91%

Anti-Hu-associated Paraneoplastic Encephalomyelitis with Esophageal Small Cell Carcinoma

et al. 2012

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A 63-year-old woman had anti-Hu-associated paraneoplastic encephalomyelitis (anti-Hu syndrome) caused by esophageal small cell carcinoma (SCC). The patient developed bilateral limbic encephalitis, followed by myelitis, brain stem encephalitis, and autonomic failure. Extensive examination demonstrated SCC of the abdominal lymph nodes that was retrospectively diagnosed as metastasis of esophageal SCC on autopsy. The neuropathological findings were characterized by widespread neuronal loss and gliosis in the central nervous system, as well as patchy loss of myelin and axons in the spinal nerve roots with perivascular lymphocytic infiltration. This is the first detailed clinical and neuropathological report of anti-Hu syndrome caused by esophageal SCC.

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Section: Case Reportsupporting

confidence: 91%

Anti-Hu-associated Paraneoplastic Encephalomyelitis with Esophageal Small Cell Carcinoma

et al. 2012

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“…Second, other investigators have demonstrated that activated circulating CD8+ T cells from patients with anti-Hu syndrome cause lysis of autologous fibroblasts previously injected with recombinant Hu-D protein [14]. In a separate work, those same investigators found similar results using MHC class I-restricted Hu-D peptides instead of the whole protein [15]. Finally, cytotoxic responses were elicited with Hu-D peptides in transgenic mice expressing human HLA-A2 molecules [16].…”

Section: Introductionmentioning

confidence: 84%

T cell response to Hu-D peptides in patients with anti-Hu syndrome

et al. 2005

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“…This has suggested a mechanism where tumour expression of specific proteins triggers an immunological response that results in the paraneoplastic disorder [10]. Anti-Hu antibodies react with nervous system neuronal nuclei and with small cell lung cancers [11, 12]. Examples of neurological diseases with transferable antibodies are the Lambert-Eaton syndrome and myasthenia gravis [2].…”

Section: Discussionmentioning

confidence: 99%

Bilateral Tonic Pupils with Evidence of Anti-Hu Antibodies as a Paraneoplastic Manifestation of Small Cell Lung Cancer

et al. 2004

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Introduction: Ophthalmological manifestations of systemic malignancies can be either direct, metastatic or paraneoplastic. The latter are remote effects of carcinoma, often caused by autoantibodies. Ophthalmological manifestations include cancer-associated retinopathy, melanoma-associated retinopathy, opsoclonus-myoclonus syndrome or motility disorders due to effects on the neurological system. A unilateral tonic pupil is usually a benign finding but has also been described in the context of paraneoplastic syndromes, in some cases associated with anti-Hu antibodies. Case Reports: The authors describe 2 patients with bilateral symptomatic tonic pupils due to a paraneoplastic syndrome. Both patients had been treated for small cell lung cancer and had evidence of anti-Hu antibodies (autoantibodies against nuclei of neural cells) in serum and cerebrospinal fluid. Both had typical pupillary findings and hypersensitivity to diluted pilocarpine. The first patient also had sensory neuronopathy, the second affection of several cranial nerves. Discussion: To the best of our knowledge, to date no case of bilateral tonic pupils has been published due to a paraneoplastic disorder with evidence of autoantibodies. This is surprising, as it is probable that autoantibodies in paraneoplastic disorders affect both ciliary ganglions in a similar way.

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Cytotoxic T cell activity against peptides of Hu protein in anti-Hu syndrome

Cited by 48 publications

References 28 publications

Anti-Hu-associated Paraneoplastic Encephalomyelitis with Esophageal Small Cell Carcinoma

Anti-Hu-associated Paraneoplastic Encephalomyelitis with Esophageal Small Cell Carcinoma

T cell response to Hu-D peptides in patients with anti-Hu syndrome

Bilateral Tonic Pupils with Evidence of Anti-Hu Antibodies as a Paraneoplastic Manifestation of Small Cell Lung Cancer

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