2024
DOI: 10.1016/j.heliyon.2023.e23308
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Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) +49A>G (rs231775) gene polymorphism is not associated with COVID-19 severity and mortality in an Iranian population

Ensie Sadat Mirsharif,
Abdolrahman Rostamian,
Mohammadreza Salehi
et al.
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Cited by 1 publication
(2 citation statements)
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“…70 Exploring synergistic combinations with various immunotherapies goes beyond CTLA-4 alone. 71 The combined targeting of CTLA-4 and PD-1 has shown remarkable success in treating certain cancers, underscoring the power of dual inhibition strategies. Moreover, enhancing the efficacy of CTLA-4 inhibition may be achievable by focusing on the downstream signaling pathways in Tregs, especially targeting STAT3.…”
Section: Functionmentioning
confidence: 99%
See 1 more Smart Citation
“…70 Exploring synergistic combinations with various immunotherapies goes beyond CTLA-4 alone. 71 The combined targeting of CTLA-4 and PD-1 has shown remarkable success in treating certain cancers, underscoring the power of dual inhibition strategies. Moreover, enhancing the efficacy of CTLA-4 inhibition may be achievable by focusing on the downstream signaling pathways in Tregs, especially targeting STAT3.…”
Section: Functionmentioning
confidence: 99%
“…It opens up possibilities for targeting it signaling mechanisms in a way that can modulate the immune response for treating various diseases effectively . Exploring synergistic combinations with various immunotherapies goes beyond CTLA-4 alone . The combined targeting of CTLA-4 and PD-1 has shown remarkable success in treating certain cancers, underscoring the power of dual inhibition strategies.…”
Section: Cd25mentioning
confidence: 99%