Cytotoxic T-lymphocyte-associated antigen-4 polymorphisms and susceptibility to cervical cancer: A meta-analysis

Abstract

Abstract. Cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) polymorphisms have been examined for associations with cervical cancer in various countries. The results, however, are inconclusive. The present study aimed to explore whether CTLA-4 +49 A/G, -318 C/T and CT60 G/A polymorphisms confer susceptibility to cervical cancer. A meta-analysis was performed with 7,794 subjects included in 15 case-control studies that were published up to January 1, 2013. The results from the meta-analysis indicated that there were no significant associations between the risk of cervical cancer and the three studied polymorphisms [+49 A/G: Odds ratio (OR), 0.94 and 95% confidence interval (CI), 0.82-1.07 for GG+AG vs. AA; -318 C/T: OR, 1.33 and 95% CI, 0.82-2.16 for TT+TC vs. CC; and CT60: OR, 0.98 and 95% CI, 0.72-1.33 for AA+AG vs. GG]. Stratified analyses by ethnicity for the +49 A/G and -318 C/T polymorphisms suggested that Asian populations had a decreased risk of cervical cancer for the +49 A/G polymorphism (OR, 0.75 and 95% CI, 0.58-0.97 for GG+AG vs. AA), but an increased risk for the -318 C/T polymorphism (OR, 2.02 and 95% CI, 1.36-3.00 for TC vs. CC). In summary, the current meta-analysis showed that the +49 A/G and -318 C/T polymorphisms in CTLA-4 constitute risk factors for cervical cancer.

Immune Checkpoint Molecules—Inherited Variations as Markers for Cancer Risk

“…In a stratified analysis by ethnicity, a significant association was observed for CTLA-4c.-319*T allele in Asian, but not in Caucasian women. This meta-analysis confirmed the results of the previous studies ( 79 , 80 ). Of note, in study by Pawlak et al ( 73 ) the significant association between CTLA-4c.-319*T allele and G1 grade of tumor was found.…”

“…In the study by Xiong et al. (365 women - cases and controls) the carriage of CTLA-4CT60*G allele was associated with increased cervical cancer risk (OR = 1.92), and with more advanced stages of this disease ( 37 ), whereas the other studies did not demonstrate such association ( 73 , 75 , 80 ).…”

Impact of Host Molecular Genetic Variations and HIV/HPV Co-infection on Cervical Cancer Progression: A Systematic review

“…h) Can further research confirm whether susceptibility loci in one population are specifically replicated in another e.g. HLA, 4q12, 17q12 (80,116,143,144)? i) Why is the apparent effect of the P72R polymorphism in TP53 gene not consistent in different ethnicities (116)?…”

Emerging Therapeutic Strategies of Different Immunotherapy Approaches Combined with PD-1/PD-L1 Blockade in Cervical Cancer

“… 32 , 33 Certain types of CTLA-4 genetic polymorphism have been proven to be relevant to an increased risk of cervical cancer. 34 , 35 CTLA-4 is expressed on more than 50% of invasive cervical cancer cells and is associated with the clinical stage of the tumor and lymph node metastasis. 36 A clinical trial has found that ipilimumab (anti-CTLA-4) following chemoradiation therapy in locally advanced cervical cancer patients induced an expansion of central and effector memory T cells.…”